Results 11 to 20 of about 40,097 (234)

BIRC5 drives cell-cycle dysregulation and represents a novel molecular target in retinoblastoma [PDF]

Frontiers in Oncology
Aims and objectivesRetinoblastoma is the most common pediatric intraocular malignancy, although it remains a rare disease overall, yet the molecular targets and therapeutic vulnerabilities sustaining its most aggressive proliferative cell states remain ...
Yingtong Chen, Xiaohan Li, Fuhua Zhong, Xiaoya Wang, Qiang Wang, Di Cao, Shaowei Dong, Chengyue Zhang, Huibin Song, Chen Lin   +9 more
doaj   +2 more sources

RPL41 inhibits the proliferation and migration of retinoblastoma through the ARL5B-associated lysosomal trafficking [PDF]

Frontiers in Immunology
PurposeRetinoblastoma is the most common intraocular cancer in infants and children, with a significant potential for metastasis. The mini-peptide ribosomal protein L41 (RPL41) has demonstrated extensive antitumor effects in vitro by promoting the ...
Ye Li, Tian Zhan, Tianfu Chen, Qianwen Zhong, Sheng Xiao, Aiyuan Wang, Yisheng Jiao   +6 more
doaj   +2 more sources

Transcriptome profiling of uterine leiomyosarcomas identifies a leiomyoma-like expression pattern that indicates better survival [PDF]

BJC Reports
Background Uterine leiomyosarcomas are rare and aggressive cancers with poor survival. Their non-cancerous counterparts, uterine leiomyomas, are common tumors affecting many women during reproductive years.
Sara Khamaiseh, Riitta Koivisto-Korander, Nora Schreiber, Esa Pitkänen, Terhi Ahvenainen, Ralf Bützow, Miika Mehine, Pia Vahteristo   +7 more
doaj   +2 more sources

Epigenetic Factors in Pathogenesis of Retinoblastoma: DNA Methylation and Histone Acetylation [PDF]

Current Issues in Molecular Biology
(Background) Retinoblastoma is the most common intraocular malignancy in childhood, primarily caused by mutations in the RB1 gene. However, increasing evidence highlights the significant role of epigenetic mechanisms, particularly DNA methylation and ...
Georgios Kiosis, Kanellos Skourtsidis, Despoina Ioannou, Vasilis-Spyridon Tseriotis, Konstantinos Stergiou, Fani Akritidou, Theodora Papamitsou, Maria Kourti, Sofia Karachrysafi   +8 more
doaj   +2 more sources

Analysis of retinoblastoma-associated genes using bioinformatic methods

Digital Diagnostics, 2023
BACKGROUND: Retinoblastoma is a common neoplasia that affects the visual organ in young children. The mortality rate is approximately 15%. In 91% of cases, surgery with enucleation is required, which significantly reduces the patients quality of life ...
Kirill Yu. Klimov
doaj   +1 more source

Retinoblastoma family genes [PDF]

Oncogene, 2006
The retinoblastoma gene Rb was the first tumor suppressor gene cloned, and it is well known as a negative regulator of the cell cycle through its ability to bind the transcription factor E2F and repress transcription of genes required for S phase. Although over 100 other proteins have been reported to interact with Rb, in most cases these interactions ...
W, Du, J, Pogoriler
openaire   +2 more sources

Loss of retinoblastoma gene and amplification of N-myc gene in retinoblastoma [PDF]

Journal of Korean Medical Science, 1993
We have analyzed paired samples of genomic DNA from peripheral leukocyte and primary tumor tissue from nine patients with retinoblastoma (RB) and from two RB cell lines, WERI-Rb-1 and Y79, to detect the molecular alterations of the retinoblastoma susceptibility gene (RB-1) and N-myc gene.
S W, Choi, T W, Lee, S W, Yang, W S, Hong, C M, Kim, J O, Lee   +5 more
openaire   +2 more sources

Bioinformatics analysis of key biomarkers for retinoblastoma

Journal of International Medical Research, 2021
Objective To identify key genes involved in occurrence and development of retinoblastoma. Methods The microarray dataset, GSE5222, was downloaded from the gene expression omnibus (GEO) database.
Xin-mei Zhao, Yuan-Bin Li, Peng Sun, Ya-di Pu, Meng-jie shan, Yuan-meng Zhang   +5 more
doaj   +1 more source

Multi-Functionalized Nanomaterials and Nanoparticles for Diagnosis and Treatment of Retinoblastoma

Biosensors, 2021
Retinoblastoma is a rare type of cancer, and its treatment, as well as diagnosis, is challenging, owing to mutations in the tumor-suppressor genes and lack of targeted, efficient, cost-effective therapy, exhibiting a significant need for novel approaches
Rabia Arshad, Mahmood Barani, Abbas Rahdar, Saman Sargazi, Magali Cucchiarini, Sadanand Pandey, Misook Kang   +6 more
doaj   +1 more source

A Meta-Analysis of Retinoblastoma Copy Numbers Refines the List of Possible Driver Genes Involved in Tumor Progression. [PDF]

PLoS ONE, 2016
BACKGROUND:While RB1 loss initiates retinoblastoma development, additional somatic copy number alterations (SCNAs) can drive tumor progression. Although SCNAs have been identified with good concordance between studies at a cytoband resolution, accurate ...
Irsan E Kooi, Berber M Mol, Maarten P G Massink, Marcus C de Jong, Pim de Graaf, Paul van der Valk, Hanne Meijers-Heijboer, Gertjan J L Kaspers, Annette C Moll, Hein Te Riele, Jacqueline Cloos, Josephine C Dorsman   +11 more
doaj   +1 more source