Results 11 to 20 of about 2,134,276 (240)

Retinoblastoma: From genes to patient care

European Journal of Medical Genetics, 2023
Retinoblastoma is the most common paediatric neoplasm of the retina, and one of the earliest model of cancer genetics since the identification of the master tumour suppressor gene RB1. Tumorigenesis has been shown to be driven by pathogenic variants of the RB1 locus, but also genomic and epigenomic alterations outside the locus.
Y. Bouchoucha, A. Matet, A. Berger, A.M. Carcaboso, A. Gerrish, A. Moll, H. Jenkinson, P. Ketteler, J.C. Dorsman, G. Chantada, M. Beck-Popovic, F. Munier, I. Aerts, F. Doz, L. Golmard   +14 more
openaire   +5 more sources

BTG interacts with retinoblastoma to control cell fate in Dictyostelium. [PDF]

PLoS ONE, 2010
BACKGROUND: In the genesis of many tissues, a phase of cell proliferation is followed by cell cycle exit and terminal differentiation. The latter two processes overlap: genes involved in the cessation of growth may also be important in triggering ...
Daniele Conte, Harry K MacWilliams, Adriano Ceccarelli   +2 more
doaj   +3 more sources

Non-coding and Coding Transcriptional Profiles Are Significantly Altered in Pediatric Retinoblastoma Tumors [PDF]

Frontiers in Oncology, 2019
Retinoblastoma is a rare pediatric tumor of the retina, caused by the homozygous loss of the Retinoblastoma 1 (RB1) tumor suppressor gene. Previous microarray studies have identified changes in the expression profiles of coding genes; however, our ...
Swetha Rajasekaran, Swetha Rajasekaran, Swetha Rajasekaran, Lakshmi Dhevi Nagarajha Selvan, Kathleen Dotts, Kathleen Dotts, Kathleen Dotts, Ranjith Kumar, Pukhraj Rishi, Vikas Khetan, Madhoolika Bisht, Madhoolika Bisht, Madhoolika Bisht, Karthikeyan Sivaraman, Subrmanian Krishnakumar, Debashis Sahoo, Moray J. Campbell, Sailaja V. Elchuri, Wayne O. Miles, Wayne O. Miles, Wayne O. Miles   +20 more
doaj   +4 more sources

Epigenetic Reprogramming by Decitabine in Retinoblastoma

Frontiers in Bioscience-Landmark
Introduction: Retinoblastoma (Rb) is a rare cancer, yet it is the most common eye tumor in children. It can occur in either a familial or sporadic form, with the sporadic variant being more prevalent, though its downstream effects on ...
Lisa Gherardini, Ankush Sharma, Monia Taranta, Caterina Cinti   +3 more
doaj   +2 more sources

Correlation of gene expression with magnetic resonance imaging features of retinoblastoma: a multi-center radiogenomics validation study [PDF]

, 2023
OBJECTIVES To validate associations between MRI features and gene expression profiles in retinoblastoma, thereby evaluating the repeatability of radiogenomics in retinoblastoma.
Moll, Annette C., Sirin, Selma, Robin W. Jansen, Sophia Göricke, de Jong, Marcus C, Maeder, Philippe, Brisse, Hervé J., Paolo Galluzzi, Castelijns, Jonas A, de Jong, Marcus C., Pim de Graaf, de Graaf, Pim, Cardoen, Liesbeth, Liesbeth Cardoen, Uner, Ogul E, Hervé J. Brisse, Khashayar Roohollahi, On behalf of the European Retinoblastoma Imaging Collaboration, Grossniklaus, Hans, de Jong, Yvonne, de Bloeme, Christiaan M., Hans Grossniklaus, Jansen, Robin W., Annette C. Moll, Galluzzi, Paolo, Hubbard, G Baker, Josephine Dorsman, Jansen, Robin W, Philippe Maeder, Brisse, Hervé J, Jonas A. Castelijns, Hubbard, G. Baker, Moll, Annette C, Ogul E. Uner, Marcus C. de Jong, Christiaan M. de Bloeme, Dorsman, Josephine, Roohollahi, Khashayar, Selma Sirin, Göricke, Sophia, Paul van der Valk, Castelijns, Jonas A., G. Baker Hubbard, van der Valk, Paul, Yvonne de Jong, de Bloeme, Christiaan M, Uner, Ogul E., Uner, O.E., Castelijns, J.A., Cardoen, L., Galluzzi, P., Moll, A.C., Jansen, R.W., Brisse, H.J., Dorsman, J., de Jong, Y., de Graaf, P., Roohollahi, K., Grossniklaus, H., Maeder, P., Sirin, S., de Bloeme, C.M., van der Valk, P., Hubbard, G.B., de Jong, M.C., Göricke, S.   +65 more
core   +2 more sources

Pleiotropic effects of the gene for retinoblastoma [PDF]

Journal of Medical Genetics, 1974
Vigorous treatment of retinoblastoma in the last 30 years has resulted in a large population of survivors with useful vision, in which the late effects of genetically associated tumours can be seen. An increase in second primary tumours, mainly osteogenic sarcoma, has been found in those children who carry the germinal mutations, and not in the ...
F D, Kitchin, R M, Ellsworth
openaire   +2 more sources

Comprehensive Analysis of the Immune Cell Infiltration Landscape and Immune-Related Methylation in Retinoblastoma

Frontiers in Genetics, 2022
Retinoblastoma is a common pediatric intraocular cancer, originating from cone precursors. The development of immunotherapies can help eradicate the tumor without vision loss, which would largely improve the quality of life of patients with ...
Peiyao Mao, Yinchen Shen, Xun Xu, Jiawei Zhong   +3 more
doaj   +1 more source

Optic nerve thickening on high-spatial-resolution MRI predicts early-stage postlaminar optic nerve invasion in retinoblastoma [PDF]

, 2023
To assess the diagnostic accuracy of nerve thickening on MRI to predict early-stage postlaminar optic nerve invasion (PLONI) in retinoblastoma. Furthermore, this study aimed to incorporate measurements into a multiparametric model for radiological ...
Koob, M., Grauwels, STL, de Graaf, P., Maeder, P., Sirin, S., Cardoen, L., de Bloeme, C.M., Galluzzi, P., Moll, A.C., van Elst, S., Ketteler, P., van der Valk, P., Jansen, R.W., Brisse, H.J., de Jong, M.C., Göricke, S., Koob, Mériam, Brisse, Hervé J; https://orcid.org/, Ketteler, Petra, Jansen, Robin W; https://orcid.org/, Moll, Annette C; https://orcid.org/, de Graaf, Pim; https://orcid.org/, Cardoen, Liesbeth; https://orcid.org/, Grauwels, Steven T L, Sirin, Selma; https://orcid.org/, de Jong, Marcus C; https://orcid.org/, van Elst, Sabien; https://orcid.org/, Galluzzi, Paolo; https://orcid.org/, European Retinoblastoma Imaging Collaboration, Maeder, Philippe; https://orcid.org/, de Bloeme, Christiaan M; https://orcid.org/, Göricke, Sophia, van der Valk, Paul   +32 more
core   +1 more source

A retinoblastoma orthologue is a major regulator of S-phase, mitotic, and developmental gene expression in Dictyostelium. [PDF]

PLoS ONE, 2012
The retinoblastoma tumour suppressor, Rb, has two major functions. First, it represses genes whose products are required for S-phase entry and progression thus stabilizing cells in G1.
Kimchi Strasser, Gareth Bloomfield, Asa MacWilliams, Adriano Ceccarelli, Harry MacWilliams, Adrian Tsang   +5 more
doaj   +1 more source

Downregulation of miR-211-5p Promotes Carboplatin Resistance in Human Retinoblastoma Y79 Cells by Affecting the GDNF–LIF Interaction

Frontiers in Oncology, 2022
PurposeTo investigate the role of the miR-211-5p-GDNF signaling pathway in carboplatin resistance of retinoblastoma Y79 cells and what factors it may be affected by.MethodsA carboplatin-resistant retinoblastoma cell line (Y79R) was established in vitro ...
Ning Ke, Lin Chen, Qing Liu, Haibo Xiong, Xinke Chen, Xiyuan Zhou   +5 more
doaj   +1 more source