Results 1 to 10 of about 107,123 (321)

Targeting RB1 Loss in Cancers [PDF]

Cancers, 2021
Retinoblastoma protein 1 (RB1) is encoded by a tumor suppressor gene that was discovered more than 30 years ago. Almost all mitogenic signals promote cell cycle progression by braking on the function of RB1 protein through mono- and subsequent hyper ...
Paing Linn, Dominic Chih-Cheng Voon, Chiaki Takahashi   +2 more
exaly   +5 more sources

Myostain is involved in ginsenoside Rb1-mediated anti-obesity

Pharmaceutical Biology, 2022
Context Obesity, one of the major public health problems worldwide, has attracted increasing attention. Ginsenoside Rb1 is the most abundant active component of Panax ginseng C.A.Mey (Araliaceae) and is reported to have beneficial effects on obesity and ...
Hong-Shi Li, Jiang-Ying Kuang, Gui-Jun Liu, Wei-Jie Wu, Xian-Lun Yin, Hao-Dong Li, Lei Wang, Tao Qin, Wen-Cheng Zhang, Yuan-Yuan Sun   +9 more
doaj   +2 more sources

Ginsenoside Rb1 inhibits astrocyte activation and promotes transfer of astrocytic mitochondria to neurons against ischemic stroke

Redox Biology, 2022
Astrocytes activation in response to stroke results in altered mitochondrial exchange with neurons. Ginsenoside Rb1is a major ginsenoside of Panax ginseng particularly known for its neuroprotective potential.
Yuan-Yuan Cai, Raphaël N Alolga, Feng-Qing Huang   +2 more
exaly   +2 more sources

Human PPP1R26P1 functions as cis-repressive element in mouse Rb1. [PDF]

PLoS ONE, 2013
The human retinoblastoma gene (RB1) is imprinted; the mouse Rb1 gene is not. Imprinted expression of RB1 is due to differential methylation of a CpG island (CpG85), which is located in the pseudogene PPP1R26P1 in intron 2 of RB1. CpG85 serves as promoter
Laura Steenpass, Deniz Kanber, Michaela Hiber, Karin Buiting, Bernhard Horsthemke, Dietmar Lohmann   +5 more
doaj   +2 more sources

Ginsenoside Rb1 exerts neuroprotective effects through regulation of Lactobacillus helveticus abundance and GABAA receptor expression

Journal of Ginseng Research, 2020
Background: Ginsenoside Rb1 (Rb1), one of the most abundant protopanaxadiol-type ginsenosides, exerts excellent neuroprotective effects even though it has low intracephalic exposure.
Haofeng Li, Dian Kang, Chong Chen
exaly   +3 more sources

The osteogenesis of Ginsenoside Rb1 incorporated silk/micro-nano hydroxyapatite/sodium alginate composite scaffolds for calvarial defect

International Journal of Oral Science, 2022
Ginsenoside Rb1, the effective constituent of ginseng, has been demonstrated to play favorable roles in improving the immunity system. However, there is little study on the osteogenesis and angiogenesis effect of Ginsenoside Rb1.
Yuqiong Wu, Jiahui Du, Qianju Wu, Ao Zheng, Lingyan Cao, Xinquan Jiang   +5 more
doaj   +2 more sources

Ginsenoside Rb1 prevents deoxynivalenol-induced immune injury via alleviating oxidative stress and apoptosis in mice

Ecotoxicology and Environmental Safety, 2021
Deoxynivalenol (DON) is considered to be a grave threat to humans and animals. Ginsenoside Rb1 (Rb1) has been reported for its antioxidant potential and medicinal properties.
Shahid Ali Rajput, Aftab Shaukat, Imran Rashid Rajput, Asghar Ali Kamboh, Zahid Iqbal, Muhammad Saeed, Rana Waseem Akhtar, Syed Aftab Hussain Shah, Muhammad Asif Raza, Ahmad El Askary, Mohamed M. Abdel-Daim, Zuhair M. Mohammedsaleh, Rabab M. Aljarai, Muna O. Alamoudi, Mashael Alhumaidi Alotaibi   +14 more
doaj   +2 more sources

RB1-I680T mutation potentiates tumor growth and chemotherapy sensitivity in non-small cell lung cancer via derepressing E2F1 transcription [PDF]

Cell Communication and Signaling
Background Retinoblastoma Transcriptional Corepressor 1 (RB1) is a critical tumor suppressor restricting the malignant progression of cancer cells. Emerging evidence indicates that RB1 mutations typically promote tumorigenesis through loss of its tumor ...
Yilin Zhu, Fengyuan Gao, Yu Liu, Jinfu Wang, Fanrong Liu, Biao Wang, Boxuan Wu, Yue Wang, Yifan Zhang, Zhongxian Tian, Ning Mu, Xianglin Zhang, Xiaogang Zhao, Yunpeng Zhao, Peichao Li   +14 more
doaj   +2 more sources

Novel ultra-small micelles based on ginsenoside Rb1: a potential nanoplatform for ocular drug delivery

Drug Delivery, 2019
Objectives: Ginsenosides Rb1 (Rb1) could form micelles in aqueous solutions. Self-assembled Rb1 micelles could potentially be utilized as ocular drug delivery system, and it was postulated that the encapsulation of a medicine within Rb1 micelles might ...
Mengshuang Li, Xiaochen Wu
exaly   +2 more sources

Ginsenoside Rb1 ameliorates Glycemic Disorder in Mice With High Fat Diet-Induced Obesity via Regulating Gut Microbiota and Amino Acid Metabolism

Frontiers in Pharmacology, 2021
Accumulating evidences suggested an association between gut microbiome dysbiosis and impaired glycemic control. Ginsenoside Rb1 (Rb1) is a biologically active substance of ginseng, which serves anti-diabetic effects.
Xueyuan Yang, Bangjian Dong, Bangjian Dong, Lijun An, Qi Zhang, Yao Chen, Honglin Wang, Ziteng Song   +7 more
doaj   +2 more sources