Results 31 to 40 of about 107,123 (321)

Pharmacological induction of translational readthrough of nonsense mutations in the retinoblastoma (RB1) gene.

PLoS ONE, 2023
The retinoblastoma protein (Rb) is encoded by the RB1 tumor suppressor gene. Inactivation of RB1 by inherited or somatic mutation occurs in retinoblastoma and various other types of tumors.
Mireia Palomar-Siles, Viktor Yurevych, Vladimir J N Bykov, Klas G Wiman   +3 more
doaj   +1 more source

A dual Keap1 and p47phox inhibitor Ginsenoside Rb1 ameliorates high glucose/ox-LDL-induced endothelial cell injury and atherosclerosis

Cell Death and Disease, 2022
Oxidative stress is a vital contributor to the development and progression of diabetes-accelerated atherosclerosis. Nuclear factor erythroid 2-related factor 2 (Nrf2) is a well-known molecule that participates in cellular defense against oxidative stress.
Z. Wang, Kai-Ming Niu, Yu-jie Wu, Kailong Du, Lian-Wen Qi, Ye-Bo Zhou, Hai-Jian Sun   +6 more
semanticscholar   +1 more source

Neuroprotective Mechanisms of Ginsenoside Rb1 in Central Nervous System Diseases

Frontiers in Pharmacology, 2022
Panax ginseng and Panax notoginseng, two well-known herbs with enormous medical value in Asian countries, have a long usage history in China for the therapy of some diseases, such as stroke.
L. Gong, Jiayi Yin, Yu Zhang, Ren Huang, Y. Lou, Haojie Jiang, Liyan Sun, Jinjing Jia, Xiansi Zeng   +8 more
semanticscholar   +1 more source

Antidepressant-like effect of ginsenoside Rb1 on potentiating synaptic plasticity via the miR-134–mediated BDNF signaling pathway in a mouse model of chronic stress-induced depression

Journal of Ginseng Research, 2021
Background Brain-derived neurotrophic factor (BDNF)–tropomyosin-related kinase B (TrkB) plays a critical role in the pathogenesis of depression by modulating synaptic structural remodeling and functional transmission.
Guoli Wang, Tianyue An, Cong Lei, Xiaofeng Zhu, Li Yang, Lianxue Zhang, Ronghua Zhang   +6 more
semanticscholar   +1 more source

Proteogenomic characterization of cholangiocarcinoma

Hepatology, EarlyView., 2022
Proteogenomic characterization of cholangiocarcinoma with therapeutic strategies Abstract Background and Aims Cholangiocarcinoma (CCA) is a highly heterogeneous cancer with limited understanding and few effective therapeutic approaches. We aimed at providing a proteogenomic CCA characterization to inform biological processes and treatment ...
Mengjie Deng, Peng Ran, Lingli Chen, Yunzhi Wang, Zixiang Yu, Ke Cai, Jinwen Feng, Zhaoyu Qin, Yanan Yin, Subei Tan, Yang Liu, Chen Xu, Guoming Shi, Yuan Ji, Jian‐Yuan Zhao, Jian Zhou, Jia Fan, Yingyong Hou, Chen Ding   +18 more
wiley   +1 more source

High p16 expression and heterozygous RB1 loss are biomarkers for CDK4/6 inhibitor resistance in ER+ breast cancer

Nature Communications, 2021
CDK4/6 inhibitors combined with endocrine therapy have demonstrated higher antitumor activity than endocrine therapy alone for the treatment of advanced estrogen receptor-positive breast cancer.
M. Palafox, L. Monserrat, M. Bellet, G. Villacampa, A. González-Pérez, Mafalda Oliveira, F. Brasó-Maristany, N. Ibrahimi, S. Kannan, L. Mina, M. T. Herrera-Abreu, Andreu Òdena, M. Sánchez-Guixé, M. Capelán, A. Azaro, A. Bruna, O. Rodríguez, M. Guzman, J. Grueso, C. Viaplana, J. Hernández, F. Su, Kui Lin, R. Clarke, C. Caldas, J. Arribas, S. Michiels, Alicia García-Sanz, N. Turner, A. Prat, P. Nuciforo, R. Dienstmann, C. Verma, N. López-Bigas, M. Scaltriti, M. Arnedos, C. Saura, V. Serra   +37 more
semanticscholar   +1 more source

RB1, Development, and Cancer [PDF]

, 2011
The RB1 gene is the first tumor suppressor gene identified whose mutational inactivation is the cause of a human cancer, the pediatric cancer retinoblastoma. The 25 years of research since its discovery has not only illuminated a general role for RB1 in human cancer, but also its critical importance in normal development.
Meenalakshmi, Chinnam, David W, Goodrich
openaire   +2 more sources

GLP-1 stimulates glucose-derived de novo fatty acid synthesis and chain elongation during cell differentiation and insulin release

Journal of Lipid Research, 2003
Glucagon-like peptide-1 (GLP-1, 7-36) is capable of restoring normal glucose tolerance in aging, glucose-intolerant Wistar rats and is a potent causal factor in differentiation of human islet duodenal homeobox-1-expressing cells into insulin-releasing β ...
Angela Bulotta, Riccardo Perfetti, Hongxiang Hui, László G. Boros   +3 more
doaj   +1 more source

Transition from normal to cancerous cell by precancerous niche (PCN) induced chronic cell-matrix stress

4 open, 2019
The attempt to restore homeostasis, once disrupted, such that complex signaling, crosstalk between ubiquitous proteins, and a diverse range of pathways gone awry is near impossible, especially in the presence of an ongoing pathogenic stimuli with ...
Brücher Björn L.D.M., Jamall Ijaz S.
doaj   +1 more source

Cardioprotective effect of ginsenoside Rb1 via regulating metabolomics profiling and AMP-activated protein kinase-dependent mitophagy

Journal of Ginseng Research, 2022
Background: Ginsenoside Rb1, a bioactive component isolated from the Panax ginseng, acts as a remedy to prevent myocardial injury. However, it is obscure whether the cardioprotective functions of Rb1 are related to the regulation of endogenous ...
Jingui Hu, Ling Zhang, Fei Fu, Qiong Lai, Lu Zhang, Tao Liu, Boyang Yu, Junping Kou, Fang Li   +8 more
doaj   +1 more source