Results 51 to 60 of about 107,123 (321)

Ginsenoside Rb1 Enhances Plaque Stability and Inhibits Adventitial Vasa Vasorum via the Modulation of miR-33 and PEDF

Frontiers in Cardiovascular Medicine, 2021
Background: Atherosclerosis is closely associated with proliferation of the adventitial vasa vasorum, leading to the atherosclerotic plaque progression and vulnerability.
Xiaoyan Yang, Xiaoyan Yang, Lei Wang, Zihao Zhang, Jiayi Hu, Xiaoling Liu, Hao Wen, Hao Wen, Minghao Liu, Minghao Liu, Xue Zhang, Xue Zhang, Hongyan Dai, Mei Ni, Rui Li, Rong Guo, Lei Zhang, Xiaorong Luan, Huili Lin, Mei Dong, Huixia Lu   +20 more
doaj   +1 more source

CDC25 as a common therapeutic target for triple-negative breast cancer - the challenges ahead

Molecular & Cellular Oncology, 2018
The dual phosphatase CDC25 has recently been identified as a target for diverse triple-negative breast cancers including RB1/PTEN/P53-deficient tumors. Moreover, CDC25 inhibitors effectively synergize with PI3K inhibitors to suppress tumor growth.
Eldad Zacksenhaus, Jeff C. Liu, Letizia Granieri, Ioulia Vorobieva, Dong-Yu Wang, Ronak Ghanbari-Azarnier, Huiqin Li, Amjad Ali, Philip E.D. Chung, YoungJun Ju, Zhe Jiang, Mariusz Shrestha   +11 more
doaj   +1 more source

Expression ratio of CCND1 to CDKN2A mRNA predicts RB1 status of cultured cancer cell lines and clinical tumor samples

Molecular Cancer, 2011
Background The retinoblastoma product (RB1) is frequently deregulated in various types of tumors by mutation, deletion, or inactivation through association with viral oncoproteins.
Itadani Hiraku, Komatani Hideya, Kobayashi Tsutomu, Machida Takumitsu, Mizuarai Shinji, Kotani Hidehito   +5 more
doaj   +1 more source

Cross-species identification of PIP5K1-, splicing- and ubiquitin-related pathways as potential targets for RB1-deficient cells.

PLoS Genetics, 2021
The RB1 tumor suppressor is recurrently mutated in a variety of cancers including retinoblastomas, small cell lung cancers, triple-negative breast cancers, prostate cancers, and osteosarcomas. Finding new synthetic lethal (SL) interactions with RB1 could
Andrey A Parkhitko, Arashdeep Singh, Sharon Hsieh, Yanhui Hu, Richard Binari, Christopher J Lord, Sridhar Hannenhalli, Colm J Ryan, Norbert Perrimon   +8 more
doaj   +1 more source

Ginsenoside Rb1 Protects Against Diabetic Cardiomyopathy by Regulating the Adipocytokine Pathway

Journal of Inflammation Research, 2022
Purpose Obesity and diabetes are often accompanied by chronic inflammation and insulin resistance, which lead to complications such as diabetic cardiomyopathy. Ginsenoside Rb1 has been used to treat diabetes and obesity and reduce inflammation as well as
Chenyang Zhang, M. Han, Xuelian Zhang, Hongna Tong, Xiaobo Sun, Guibo Sun   +5 more
semanticscholar   +1 more source

Imprinting of RB1 (the new kid on the block) [PDF]

Briefings in Functional Genomics, 2010
Recent data have revealed that the paradigmatic tumour suppressor gene RB1 on chromosome 13 is preferentially expressed from the maternal allele. Imprinted expression of RB1 is linked to a differentially methylated CpG island in intron 2 of this gene (CpG 85).
Buiting, Karin, Kanber, Deniz, Horsthemke, Bernhard, Lohmann, Dietmar   +3 more
openaire   +2 more sources

Korean Red Ginseng and Rb1 facilitate remyelination after cuprizone diet-induced demyelination

Journal of Ginseng Research, 2023
Background: Demyelination has been observed in neurological disorders, motivating researchers to search for components for enhancing remyelination. Previously we found that Rb1, a major ginsenoside in Korean Red Ginseng (KRG), enhances myelin formation ...
Oh Wook Kwon, Dalnim Kim, Eugene Koh, Hyun-Jeong Yang   +3 more
doaj   +1 more source

Direct Involvement of Retinoblastoma Family Proteins in DNA Repair by Non-homologous End-Joining.

, 2015
Deficiencies in DNA double-strand break (DSB) repair lead to genetic instability, a recognized cause of cancer initiation and evolution. We report that the retinoblastoma tumor suppressor protein (RB1) is required for DNA DSB repair by canonical non ...
Spanswick, VJ, Maciej T. Luczynski, Rieger, Simone, Luczynski, Maciej T., Cook, Rebecca, Cook, R, Hartley, JA, Paul H. Huang, Victoria J. Spanswick, Huang, Paul H., Hartley, John A., John A. Hartley, Luczynski, MT, Rieger, S, Mittnacht, Sibylle, Mittnacht, S, Spanswick, Victoria J., Moquet, J, Huang, PH, Kai Rothkamm, Zoumpoulidou, Georgia, Jayne Moquet, Zoumpoulidou, G, Georgia Zoumpoulidou, Simone Rieger, Sibylle Mittnacht, Rothkamm, K, Rebecca Cook, Moquet, Jayne, Rothkamm, Kai   +29 more
core   +1 more source

Ginsenoside Rb1 attenuates coronary microvascular inflammatory injury via NDUFS4-SIRT5-DUSP1-mediated mitochondrial quality control in a murine ischemia-reperfusion model

Journal of Ginseng Research
Background Ginsenoside Rb1 is a prominent bioactive component in traditional Chinese medicine. Purpose This study investigated the molecular mechanisms underlying the protective effects of Ginsenoside Rb1 on endothelium during ischemia-reperfusion (I/R ...
Xiangyi Pu, Jinfeng Liu, Yanli Wang, Xuanke Guan, Qiaomin Wu, Qin Zhang, Ruxiu Liu, Xing Chang   +7 more
semanticscholar   +1 more source

High-Level MYCN-Amplified RB1-Proficient Retinoblastoma Tumors Retain Distinct Molecular Signatures

Ophthalmology Science, 2022
Purpose: Retinoblastomas are malignant eye tumors diagnosed in young children. Most retinoblastomas are genetically characterized by biallelic inactivation of the RB1 gene.
Khashayar Roohollahi, MSc, Yvonne de Jong, PhD, Saskia E. van Mil, MSc, Armida W.M. Fabius, PhD, Annette C. Moll, MD, PhD, Josephine C. Dorsman, PhD   +5 more
doaj   +1 more source