Results 41 to 50 of about 107,123 (321)

Ginsenoside Rb1 attenuates age-associated vascular impairment by modulating the Gas6 pathway

Pharmaceutical Biology, 2021
Context Ginsenoside Rb1 (Rb1) exerts many beneficial effects and protects against cardiovascular disease. Objective To investigate whether Rb1 could attenuate age-related vascular impairment and identify the mechanism.
Shiye Ke, Lin Wu, Min Wang, Dinghui Liu, Guangyao Shi, Jieming Zhu, Xiaoxian Qian   +6 more
doaj   +1 more source

Ginsenosides Rb1 Attenuates Chronic Social Defeat Stress-Induced Depressive Behavior via Regulation of SIRT1-NLRP3/Nrf2 Pathways

Frontiers in Nutrition, 2022
Ginsenoside Rb1, a diol-type ginseng saponin, has various positive effects on the central nervous system. This study aimed to evaluate the antidepressant effects of Rb1 on chronic social defeat stress (CSDS) induced behavioral deficits and the exact ...
Ning Jiang, Yiwen Zhang, CA Yao, Hong Huang, Qiong Wang, Shuangxue Huang, Qinghu He, Xinmin Liu   +7 more
semanticscholar   +1 more source

Combined TP53 and RB1 Loss Promotes Prostate Cancer Resistance to a Spectrum of Therapeutics and Confers Vulnerability to Replication Stress

Cell Reports, 2020
SUMMARY Prostate cancers (PCs) with loss of the potent tumor suppressors TP53 and RB1 exhibit poor outcomes. TP53 and RB1 also influence cell plasticity and are frequently lost in PCs with neuroendocrine (NE) differentiation.
Michael D Nyquist, Alexandra Corella, Ilsa M Coleman, N. De Sarkar, A. Kaipainen, G. Ha, R. Gulati, Lisa S. Ang, P. Chatterjee, Jared M. Lucas, C. Pritchard, G. Risbridger, J. Isaacs, B. Montgomery, C. Morrissey, E. Corey, P. Nelson   +16 more
semanticscholar   +1 more source

The Origin of the RB1 Imprint

PLoS ONE, 2013
The human RB1 gene is imprinted due to a differentially methylated CpG island in intron 2. This CpG island is part of PPP1R26P1, a truncated retrocopy of PPP1R26, and serves as a promoter for an alternative RB1 transcript. We show here by in silico analyses that the parental PPP1R26 gene is present in the analysed members of Haplorrhini, which comprise
Kanber, Deniz, Buiting, Karin, Roos, Christian, Gromoll, Jörg, Kaya, Sabine, Horsthemke, Bernhard, Lohmann, Dietmar   +6 more
openaire   +6 more sources

Rb1 and Trp53 cooperate to suppress prostate cancer lineage plasticity, metastasis, and antiandrogen resistance

Science, 2017
Evading cancer drugs by identity fraud Prostate cancer growth is fueled by male hormones called androgens. Drugs targeting the androgen receptor (AR) are initially efficacious, but most tumors eventually become resistant (see the Perspective by Kelly and
Sheng-Yu Ku, S. Rosario, Yanqing Wang, P. Mu, M. Seshadri, Zachary Goodrich, Maxwell M. Goodrich, David P. Labbé, E. C. Gomez, Jian-mei Wang, Henry W. Long, Bo Xu, Myles A. Brown, M. Loda, C. Sawyers, L. Ellis, D. Goodrich   +16 more
semanticscholar   +1 more source

MRI Features for Identifying MYCN-amplified RB1 Wild-type Retinoblastoma [PDF]

, 2023
Background MYCN-amplified RB1 wild-type (MYCN$^{A}$RB1$^{+/+}$) retinoblastoma is a rare but clinically important subtype of retinoblastoma due to its aggressive character and relative resistance to typical therapeutic approaches.
Nichols, Kim E; https://orcid.org/, Brisse, Hervé J; https://orcid.org/, Ramasubramanian, Aparna, Boldt, H Culver; https://orcid.org/, Jansen, Robin W; https://orcid.org/, Castelijns, Jonas A, Dommering, Charlotte J; https://orcid.org/, Moll, Annette C; https://orcid.org/, de Graaf, Pim; https://orcid.org/, Cardoen, Liesbeth; https://orcid.org/, Sen, Saugata; https://orcid.org/, Hubbard, G Baker; https://orcid.org/, Grossniklaus, Hans, Miller, Audra K; https://orcid.org/, Sirin, Selma; https://orcid.org/, de Jong, Marcus C; https://orcid.org/, van Elst, Sabien; https://orcid.org/, Galluzzi, Paolo; https://orcid.org/, Brennan, Rachel C; https://orcid.org/, Maeder, Philippe; https://orcid.org/, de Bloeme, Christiaan M; https://orcid.org/, Uner, Ogul E; https://orcid.org/, Dorsman, Josephine, Boellaard, Ronald, Skalet, Alison H, Göricke, Sophia, Jessen, Jaime Lyn, van der Valk, Paul   +27 more
core   +1 more source

MiR‐192‐5p/RB1/NF‐κBp65 signaling axis promotes IL‐10 secretion during gastric cancer EMT to induce Treg cell differentiation in the tumour microenvironment

Clinical and Translational Medicine, 2022
Background Regulatory T (Treg) cells are important components of the tumour microenvironment (TME) that play roles in gastric cancer (GC) metastasis. Although tumour cells that undergo epithelial‐mesenchymal transition (EMT) regulate Treg cell function ...
Jialin Song, Zaihuan Lin, Qing Liu, Sihao Huang, Lei Han, Yan Fang, Panyi Zhong, Rongzhang Dou, Zhenxian Xiang, Jinsen Zheng, Xinyao Zhang, Shuyi Wang, B. Xiong   +12 more
semanticscholar   +1 more source

Skp2 is required for survival of aberrantly proliferating Rb1-deficient cells and for tumorigenesis in Rb1+/− mice [PDF]

Nature Genetics, 2009
Heterozygosity of the retinoblastoma gene Rb1 elicits tumorigenesis in susceptible tissues following spontaneous loss of the remaining functional allele. Inactivation of previously studied retinoblastoma protein (pRb) targets partially inhibited tumorigenesis in Rb1(+/-) mice. Here we report that inactivation of pRb target Skp2 (refs.
Hongbo, Wang, Frederick, Bauzon, Peng, Ji, Xiaoliang, Xu, Daqian, Sun, Joseph, Locker, Rani S, Sellers, Keiko, Nakayama, Keiich I, Nakayama, David, Cobrinik, Liang, Zhu   +10 more
openaire   +2 more sources

SOX2 promotes lineage plasticity and antiandrogen resistance in TP53- and RB1-deficient prostate cancer

Science, 2017
Evading cancer drugs by identity fraud Prostate cancer growth is fueled by male hormones called androgens. Drugs targeting the androgen receptor (AR) are initially efficacious, but most tumors eventually become resistant (see the Perspective by Kelly and
P. Mu, Zeda Zhang, M. Benelli, W. Karthaus, Elizabeth A. Hoover, Chi-Chao Chen, John Wongvipat, Sheng-Yu Ku, D. Gao, Z. Cao, Neel Shah, E. Adams, W. Abida, Philip A Watson, D. Prandi, Chun-Hao Huang, E. de Stanchina, S. Lowe, L. Ellis, H. Beltran, M. Rubin, D. Goodrich, F. Demichelis, C. Sawyers   +23 more
semanticscholar   +1 more source

Recent progress (2015–2020) in the investigation of the pharmacological effects and mechanisms of ginsenoside Rb1, a main active ingredient in Panax ginseng Meyer

Journal of Ginseng Research, 2021
Ginsenoside Rb1 (Rb1), one of the most important ingredients in Panax ginseng Meyer, has been confirmed to have favorable activities, including reducing antioxidative stress, inhibiting inflammation, regulating cell autophagy and apoptosis, affecting ...
Zuan Lin, Rongfang Xie, Chenhui Zhong, Jianyong Huang, Peiying Shi, Hong Yao   +5 more
semanticscholar   +1 more source