Results 21 to 30 of about 107,123 (321)

Systems Toxicology Approach for Assessing Developmental Neurotoxicity in Larval Zebrafish

Frontiers in Genetics, 2021
Adverse outcomes that result from chemical toxicity are rarely caused by dysregulation of individual proteins; rather, they are often caused by system-level perturbations in networks of molecular events. To fully understand the mechanisms of toxicity, it
Roman A. Li, Roman A. Li, Marja Talikka, Sylvain Gubian, Colette vom Berg, Florian Martin, Manuel C. Peitsch, Julia Hoeng, Anze Zupanic, Anze Zupanic   +9 more
doaj   +1 more source

DNA hypermethylation/boundary control loss identified in retinoblastomas associated with genetic and epigenetic inactivation of the RB1 gene promoter

Epigenetics, 2021
DNA hypermethylation events occur frequently in human cancers, but less is known of the mechanisms leading to their initiation. Retinoblastoma, an intraocular cancer affecting young children, involves bi-allelic inactivation of the RB1 gene (RB−/-).
AM Raizis, HM Racher, A Foucal, H Dimaras, BL Gallie, PM George   +5 more
doaj   +1 more source

RB1-deficient prostate tumor growth and metastasis are vulnerable to ferroptosis induction via the E2F/ACSL4 axis

Journal of Clinical Investigation, 2023
Inactivation of the RB1 tumor suppressor gene is common in several types of therapy-resistant cancers, including metastatic castration-resistant prostate cancer, and predicts poor clinical outcomes.
Mu-En Wang, Jiaqi Chen, Yi Lu, Alyssa R. Bawcom, Jinjin Wu, Jianhong Ou, J. Asara, A. Armstrong, Qianben Wang, Lei Li, Yuzhuo Wang, Jiaoti Huang, Ming Chen   +12 more
semanticscholar   +1 more source

Cellular Cytotoxicity and Epigenetic Alteration in RP1 and RASSF1A Genes as Response for Anticancer Capabilities of Some Probiotic Bacteria in Breast Cancer

Journal of Scientific Research in Science, 2021
This study aimed to assess the anti-proliferative capabilities of the three probiotic strains on breast cancer (MCF7) and test their anticancer capabilities on RP1 and RASSF1A Genes. Three probiotics bacterial strains: Lactobacillus casei ss.
Amira Hassan Ahmed, Zeinab M.H. Kheiralla, Ahmed Abdelwahab M. Abdelhafez, Abdallah S. Korayem, Shimaa Mohammad Abdelsalam   +4 more
doaj   +1 more source

Two Cases of TKI-resistant Small Cell Lung Cancer Transformation 
in Advanced Adenocarcinoma and Literature Review

Chinese Journal of Lung Cancer, 2022
Treatment of advanced non-small cell lung cancer (NSCLC) patients with epidermal growth factor receptor (EGFR) mutation with EGFR-tyrosine kinase inhibitors (EGFR-TKIs) can achieve good disease control, but it will inevitably produce drug resistance ...
Jieqiong WU, Dunqiang REN, Bingqian YI, Huanhuan BI, Yanmei SHAO, Hongmei WANG   +5 more
doaj   +1 more source

Targeting DNA methylation and B7-H3 in RB1-deficient and neuroendocrine prostate cancer

Science Translational Medicine, 2023
Aberrant DNA methylation has been implicated as a key driver of prostate cancer lineage plasticity and histologic transformation to neuroendocrine prostate cancer (NEPC).
Yasutaka Yamada, V. B. Venkadakrishnan, Kei Mizuno, Martin K. Bakht, Sheng-Yu Ku, Maria Mica Garcia, H. Beltran   +6 more
semanticscholar   +1 more source

Proteomic analysis reveals ginsenoside Rb1 attenuates myocardial ischemia/reperfusion injury through inhibiting ROS production from mitochondrial complex I

Theranostics, 2021
Rationale: Reactive oxygen species (ROS) burst from mitochondrial complex I is considered the critical cause of ischemia/reperfusion (I/R) injury.
Lujing Jiang, Xiaojian Yin, Ya-Hui Chen, Yan Chen, Wei Jiang, Hao-Chuan Zheng, Feng-Qing Huang, Baolin Liu, Wei Zhou, Lian-Wen Qi, Jia Li   +10 more
semanticscholar   +1 more source

Progress in the Conversion of Ginsenoside Rb1 into Minor Ginsenosides Using β-Glucosidases

Foods, 2023
In recent years, minor ginsenosides have received increasing attention due to their outstanding biological activities, yet they are of extremely low content in wild ginseng.
Hongrong Zhu, Rui Zhang, Zunxi Huang, Junpei Zhou   +3 more
semanticscholar   +1 more source

New models of large-cell neuroendocrine carcinoma and small-cell lung carcinoma

Molecular & Cellular Oncology, 2020
High-grade neuroendocrine lung carcinomas (LCNEC, SCLC) are recalcitrant cancers for which no optimal management has been achieved. We have recently described two models of LCNEC and SCLC developed upon inactivation of 4 tumor suppressors genes (Rb1 (RB ...
Mirentxu Santos
doaj   +1 more source

p53 and RB1 regulate Hedgehog responsiveness via autophagy-mediated ciliogenesis

Molecular & Cellular Oncology, 2020
Loss of tumor protein p53 (p53) and RB transcriptional corepressor 1 (RB1) in developmental and small cell lung cancer models promotes primary cilia formation and hyper-responsiveness to Hedgehog ligand.
Jason E. Cain, D. Neil Watkins
doaj   +1 more source