Results 11 to 20 of about 107,123 (321)

RB1 (retinoblastoma) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 1999
Review on RB1 (retinoblastoma), with data on DNA, on the protein encoded, and where the gene is ...
DR Lohmann, Lohmann, DR
core   +2 more sources

RB1 in cancer: Different mechanisms of RB1 inactivation and alterations of pRb pathway in tumorigenesis. [PDF]

Journal of Cellular Physiology, 2013
Loss of RB1 gene is considered either a causal or an accelerating event in retinoblastoma. A variety of mechanisms inactivates RB1 gene, including intragenic mutations, loss of expression by methylation and chromosomal deletions, with effects which are ...
TESORIERE, Giovanni, Giovanni Tesoriere, D'ANNEO, Antonella, Antonella D'Anneo, VENTO, Renza, Renza Vento, DI FIORE, Riccardo, Riccardo Di Fiore   +7 more
core   +5 more sources

RB1-Promotormethylierung bei Glioblastomen [PDF]

, 2021
Glioblastome sind astrozytäre Tumore, gehören zu den aggressivsten Tumorerkrankungen des Menschen und sind mit einer infausten Prognose vergesellschaftet.
Breitfelder, Gerrit
core   +2 more sources

The significance of RB1 in multiple myeloma [PDF]

Frontiers in Immunology
The treatment of multiple myeloma (MM) has significantly advanced; however, the underlying genetic mechanisms remain elusive. Clonal events and genetic alterations are recognized as pivotal in the pathogenesis of MM. It is now understood that a multitude
Rui Liu, Zujie Lin, Rui Yang, Ruoyu Yang, Aili He, Yiwen Wang   +5 more
core   +4 more sources

RB1 inactivation in cutaneous carcinomas

Histopathology
International audienceRB1 was the first identified tumour suppressor gene, named for its crucial role in opposing retinoblastoma oncogenesis. The RB1 gene encodes the retinoblastoma protein pRB, which is a well‐known negative regulator of the cell cycle.
Guyétant, Serge, Harms, Paul, Wood, Benjamin, Samimi, Mahtab, Kervarrec, Thibault, Liv, Tiffany, Schrama, David, Touzé, Antoine, Tetzlaff, Michael   +8 more
core   +6 more sources

RB1 Methylation by SMYD2 Enhances Cell Cycle Progression through an Increase of RB1 Phosphorylation

Neoplasia, 2012
It is well known that RB functions are regulated by posttranslational modifications such as phosphorylation and acetylation, but the significance of lysine methylation on RB has not been fully elucidated.
Yamaue, Hiroki, Hyun-Soo Cho, Yamane, Yuka, Cho, Hyun-Soo, Neal, David E., David E. Neal, Naoshi Dohmae, Nakamura, Yusuke, Hayami, Shinya, Bruce A.J. Ponder, Maejima, Kazuhiro, Shinya Hayami, Yusuke Nakamura, Suzuki, Takehiro, Gouji Toyokawa, Masaharu Kogure, Kogure, Masaharu, Kazuhiro Maejima, Ponder, Bruce A.J., Yuka Yamane, Takehiro Suzuki, Hamamoto, Ryuji, Toyokawa, Gouji, Dohmae, Naoshi, Kang, Daechun, Hiroki Yamaue, Daechun Kang, Ryuji Hamamoto   +27 more
core   +4 more sources

Ginsenoside Rb1 attenuates mouse cerebral ischemia/reperfusion induced neurological impairments through modulation of microglial polarization

Folia Neuropathologica
Cerebral ischemia/reperfusion causes high disability, recurrence, and mortality. Ischemic stroke is a powerful stimulus that triggers significant microglia activation.
Cong Yu, Yisong Zhang, Yijun Guo, Zhiyang Shen, Keqin Li, Wei Chen, Dabin Ren   +6 more
doaj   +2 more sources

Ginsenoside Rb1 ameliorates cisplatin-induced learning and memory impairments

Journal of Ginseng Research, 2019
Background: Ginsenoside Rb1 (Rb1), a dominant component from the extract of Panax ginseng root, exhibits neuroprotective functions in many neurological diseases.
Haifeng Zhang, Yake Zheng, Tianwen Wu
exaly   +2 more sources

Ginsenoside Rb1 alleviates diabetic kidney podocyte injury by inhibiting aldose reductase activity

Acta Pharmacologica Sinica, 2021
Quan Hong, Guangyan Cai, Jiao Guo
exaly   +2 more sources

Impact of ginsenoside Rb1 on gut microbiome and associated changes in pharmacokinetics in rats

Scientific Reports
Ginsenoside Rb1 exhibits a wide range of biological activities, and gut microbiota is considered the main metabolic site for Rb1. However, the impact of gut microbiota on the pharmacokinetics of Rb1 are still uncertain. In this study, we investigated the
Yue Chen, Kang-xi Zhang, Hui Liu, Yue Zhu, Qing-yun Bu, Shu-xia Song, Ya-chun Li, Hong Zou, Xiao-yan You, Guo-ping Zhao   +9 more
doaj   +2 more sources