Frontiers in Pharmacology, 2022 Ginsenoside Rb1, a main component of ginseng, is often transformed into ginsenoside CK by intestinal flora to exert various pharmacological activity. However, it remains unclear whether ginsenoside CK is responsible for the anti-gastric cancer effect of ...
Jia Xia, Hui Ao, Wan Yan
exaly +3 more sources
Ginsenoside Rb1 Ameliorates Age-Related Cognitive Impairment Potentially by Modulating the NF-κB Signaling Pathway. [PDF]
Brain BehavGinsenoside Rb1 may alleviate age‐related cognitive impairment by suppressing hippocampal inflammation, potentially through modulation of the NF‐κB signaling pathway. Abstract Introduction: Age‐related cognitive impairment affects the quality of life of the elderly, contributing to a substantial healthcare burden.
Lu WF +4 more
europepmc +2 more sources
Pharmacological Mechanism and Drug Research Prospects of Ginsenoside Rb1 as an Antidepressant [PDF]
AntioxidantsThis review explores the antidepressant effects of ginsenoside Rb1, a natural compound in traditional Chinese medicine, and its potential for treating major depressive disorder (MDD).
Shuhui Zhuang +6 more
doaj +2 more sources
Ginsenoside Rb1 improves energy metabolism after spinal cord injury [PDF]
Neural Regeneration Research, 2023 Mitochondrial damage caused by oxidative stress and energy deficiency induced by focal ischemia and hypoxia are important factors that aggravate diseases. Studies have shown that ginsenoside Rb1 has neurotrophic and neuroprotective effects.
Shan Wen +6 more
doaj +2 more sources
Ginsenoside Rb1 affects mitochondrial Ca2+ transport and inhibits fat deposition and fibrosis by regulating the wnt signaling pathway to treat rotator cuff tears via docking with SFRP1 [PDF]
Molecular MedicineBackground Rotator cuff tears (RCTs) are among the most common musculoskeletal disorders that affect quality of life. This study aimed to investigate the efficacy of ginsenoside Rb1 in RCTs and the mechanisms involved.
Yuesong Yin, Hai Hu, Yian Yang, Song Wu
doaj +2 more sources
Journal of Ginseng Research, 2016 Background: Minor saponins or human intestinal bacterial metabolites, such as ginsenosides Rg3, F2, Rh2, and compound K, are more pharmacologically active than major saponins, such as ginsenosides Rb1, Rb2, and Rc.
Jitendra Upadhyaya +2 more
exaly +3 more sources
Progress in the Conversion of Ginsenoside Rb1 into Minor Ginsenosides Using β-Glucosidases
Foods, 2023 In recent years, minor ginsenosides have received increasing attention due to their outstanding biological activities, yet they are of extremely low content in wild ginseng.
Zunxi Huang, Junpei Zhou, Huang Zunxi
exaly +3 more sources
Ginsenoside Rb1 as an Anti-Diabetic Agent and Its Underlying Mechanism Analysis
Cells, 2019 Panax ginseng and Panax notoginseng, two well-known medical plants with economic value, have a long history of use for managing various diseases in Asian countries.
Weijie Xie +2 more
exaly +3 more sources
Ginsenoside Rb1 attenuates coronary microvascular inflammatory injury via NDUFS4-SIRT5-DUSP1-mediated mitochondrial quality control in a murine ischemia-reperfusion model [PDF]
Journal of Ginseng ResearchBackground: Ginsenoside Rb1 is a prominent bioactive component in traditional Chinese medicine. Purpose: This study investigated the molecular mechanisms underlying the protective effects of Ginsenoside Rb1 on endothelium during ischemia-reperfusion (I/R)
Xiangyi Pu +7 more
doaj +2 more sources
Ginsenoside Rb1, salvianolic acid B and their combination modulate gut microbiota and improve glucolipid metabolism in high-fat diet induced obese mice [PDF]
PeerJ, 2021 Background To observe the effect of ginsenoside Rb1, salvianolic acid B and their combination on glucolipid metabolism and structural changes of gut microbiota. Methods Eight-week-old C57BL/6J mice were fed 45% high-fat diet to induce obesity.
Ying Bai +11 more
doaj +2 more sources