Results 1 to 10 of about 5,735 (170)

Progress in the Conversion of Ginsenoside Rb1 into Minor Ginsenosides Using β-Glucosidases

Foods, 2023
In recent years, minor ginsenosides have received increasing attention due to their outstanding biological activities, yet they are of extremely low content in wild ginseng.
Junpei Zhou, Huang Zunxi
exaly   +5 more sources

Pharmacological Mechanism and Drug Research Prospects of Ginsenoside Rb1 as an Antidepressant. [PDF]

Antioxidants (Basel)
This review explores the antidepressant effects of ginsenoside Rb1, a natural compound in traditional Chinese medicine, and its potential for treating major depressive disorder (MDD).
Zhuang S, Shi F, Cannella N, Ubaldi M, Ciccocioppo R, Li H, Qin D.   +6 more
europepmc   +4 more sources

Enzymatic formation of compound-K from ginsenoside Rb1 by enzyme preparation from cultured mycelia of Armillaria mellea

Journal of Ginseng Research, 2016
Background: Minor saponins or human intestinal bacterial metabolites, such as ginsenosides Rg3, F2, Rh2, and compound K, are more pharmacologically active than major saponins, such as ginsenosides Rb1, Rb2, and Rc.
Young-Hoi Kim, Jitendra Upadhyaya, Min-Ji Kim   +2 more
exaly   +3 more sources

Ginsenoside Rb1 improves energy metabolism after spinal cord injury. [PDF]

Neural Regen Res, 2023
Mitochondrial damage caused by oxidative stress and energy deficiency induced by focal ischemia and hypoxia are important factors that aggravate diseases. Studies have shown that ginsenoside Rb1 has neurotrophic and neuroprotective effects.
Wen S, Zou ZR, Cheng S, Guo H, Hu HS, Zeng FZ, Mei XF.   +6 more
europepmc   +2 more sources

Ginsenoside Rb1 affects mitochondrial Ca²⁺ transport and inhibits fat deposition and fibrosis by regulating the wnt signaling pathway to treat rotator cuff tears via docking with SFRP1. [PDF]

Mol Med
Background Rotator cuff tears (RCTs) are among the most common musculoskeletal disorders that affect quality of life. This study aimed to investigate the efficacy of ginsenoside Rb1 in RCTs and the mechanisms involved.
Yin Y, Hu H, Yang Y, Wu S.
europepmc   +2 more sources

Ginsenoside Rb1 as an Anti-Diabetic Agent and Its Underlying Mechanism Analysis

Cells, 2019
Panax ginseng and Panax notoginseng, two well-known medical plants with economic value, have a long history of use for managing various diseases in Asian countries.
Weijie Xie, Guibo Sun, Wen Yuxuan
exaly   +3 more sources

Ginsenoside Rb1 attenuates coronary microvascular inflammatory injury via NDUFS4-SIRT5-DUSP1-mediated mitochondrial quality control in a murine ischemia-reperfusion model. [PDF]

J Ginseng Res
Background: Ginsenoside Rb1 is a prominent bioactive component in traditional Chinese medicine. Purpose: This study investigated the molecular mechanisms underlying the protective effects of Ginsenoside Rb1 on endothelium during ischemia-reperfusion (I/R)
Pu X, Liu J, Wang Y, Guan X, Wu Q, Zhang Q, Liu R, Chang X.   +7 more
europepmc   +2 more sources

Ginsenoside CK, rather than Rb1, possesses potential chemopreventive activities in human gastric cancer via regulating PI3K/AKT/NF-κB signal pathway

Frontiers in Pharmacology, 2022
Ginsenoside Rb1, a main component of ginseng, is often transformed into ginsenoside CK by intestinal flora to exert various pharmacological activity. However, it remains unclear whether ginsenoside CK is responsible for the anti-gastric cancer effect of ...
Yan Wan, Dong Liu, Jia Xia, Jin-Feng Xu, Li Zhang, Yu Yang, Jiao-Jiao Wu, Hui Ao, Hui Ao   +8 more
doaj   +1 more source

Ginsenoside Rb1, salvianolic acid B and their combination modulate gut microbiota and improve glucolipid metabolism in high-fat diet induced obese mice [PDF]

PeerJ, 2021
Background To observe the effect of ginsenoside Rb1, salvianolic acid B and their combination on glucolipid metabolism and structural changes of gut microbiota. Methods Eight-week-old C57BL/6J mice were fed 45% high-fat diet to induce obesity.
Ying Bai, Xueli Bao, Qianqian Mu, Xin Fang, Ruyuan Zhu, Chenyue Liu, Fangfang Mo, Dongwei Zhang, Guangjian Jiang, Ping Li, Sihua Gao, Dandan Zhao   +11 more
doaj   +2 more sources

The osteogenesis of Ginsenoside Rb1 incorporated silk/micro-nano hydroxyapatite/sodium alginate composite scaffolds for calvarial defect

International Journal of Oral Science, 2022
Ginsenoside Rb1, the effective constituent of ginseng, has been demonstrated to play favorable roles in improving the immunity system. However, there is little study on the osteogenesis and angiogenesis effect of Ginsenoside Rb1.
Yuqiong Wu, Jiahui Du, Qianju Wu, Ao Zheng, Lingyan Cao, Xinquan Jiang   +5 more
doaj   +1 more source