Anti-Angiogenic Properties of Ginsenoside Rg3
Molecules, 2020 Ginsenoside Rg3 (Rg3) is a member of the ginsenoside family of chemicals extracted from Panax ginseng. Like other ginsenosides, Rg3 has two epimers: 20(S)-ginsenoside Rg3 (SRg3) and 20(R)-ginsenoside Rg3 (RRg3).
Jennifer E Hardingham +2 more
exaly +3 more sources
Ginsenoside Rg3 ameliorates allergic airway inflammation and oxidative stress in mice
Journal of Ginseng Research, 2021 Background: Ginsenoside Rg3, isolated from Panax ginseng, has anti-inflammatory and anti-tumor activities. It is known to reduce inflammation in acute lung injury in mice, and to reduce the expression of inflammatory cytokines and COX-2 in human ...
Huang Wen-Chung +2 more
exaly +3 more sources
Journal of Ginseng Research, 2015 Background: Ginsenoside Rg3 is a promising anticancer agent. It is usually produced by heat treatment of ginseng, in which ginsenoside Rb1 is the major ginsenoside.
Jae Youl Cho +2 more
exaly +3 more sources
Journal of Ginseng Research, 2020 Background: 20(S)-ginsenoside-Rg3 (C42H72O13), a natural triterpenoid saponin, is extracted from red ginseng. The increasing use of 20(S)-ginsenoside Rg3 has raised product safety concerns. Methods: In acute toxicity, 20(S)-ginsenoside Rg3 was singly and
Jingwei Tian, Guisheng Li
exaly +3 more sources
Ginsenoside Rg3 attenuates myocardial ischemia/reperfusion-induced ferroptosis via the keap1/Nrf2/GPX4 signaling pathway [PDF]
BMC Complementary Medicine and TherapiesBackground Ginsenoside Rg3 is a component of ginseng that protects against myocardial ischemia/reperfusion (MI/R) injury. Ferroptosis is a new form of cell death characterized by oxidative damage to phospholipids. The purpose of this study was to examine
GuoFu Zhong +9 more
doaj +2 more sources
Synergistic inhibition of macular vascular permeability in diabetic edema: Ginsenoside Rg3 enhances ranibizumab efficacy by targeting angiopoietin‐like protein 4 and vascular endothelial growth factor via neuropilin/RhoA signaling [PDF]
Journal of Diabetes InvestigationAims This study investigated the molecular mechanisms by which ginsenoside Rg3 combined with ranibizumab alleviates diabetic macular edema (DME), focusing on antagonizing ANGPTL4/VEGF and regulating the NRP/RhoA pathway to reduce vascular permeability ...
Jiexin Yu, Xingyu Li, Yanli Liu
doaj +2 more sources
The Pharmacological Mechanisms Underlying the Protective Effect of Ginsenoside Rg3 against Heart Failure [PDF]
Cardiology Research and PracticeBackground. Heart failure represents the terminal stage of various cardiovascular diseases. This study aims to explore the pharmacological mechanisms underlying the protective effect of Ginsenoside Rg3 against heart failure. Methods. Potential targets of
Yanan Jia, Miao Gong, Zunping Ke
doaj +2 more sources
Protective effects of 20(R) ginsenoside Rg3 on DBP-induced reproductive injury in mice through Nrf2/ARE pathway [PDF]
Scientific ReportsDi-n-butyl phthalate (DBP), an environmental endocrine disruptor, can induce male reproductive dysfunction. In the study, the protective mechanism of ginsenoside Rg3 (Rg3) against DBP-induced damage to spermatogenic function was explored through the Nrf2/
Huan Li +5 more
doaj +2 more sources
Heliyon, 2023 Although ginsenoside Rg3 has been shown to exert anticancer effects in various malignancies, the effects and molecular mechanisms of ginsenoside Rg3 in cervical cancer (CC) remain unclear.
Hui Liu, Tingting Xie, Yuan Liu
doaj +1 more source
Network Analysis of 20S-Ginsenoside Rg3 Effect on Human Colorectal Adenocarcinoma Cell Line HT-29 [PDF]
Research Journal of Pharmacognosy, 2022 Background and objectives: 20S-Ginsenoside Rg3 is a pharmacological active compound of ginseng. Evidences indicate that S20-Rg3 as an anti-cancer factor plays role in prevention and treatment of cancer.
Mona Zamanian Azodi +5 more
doaj +1 more source