Anti-Angiogenic Properties of Ginsenoside Rg3 [PDF]
Molecules, 2020 Ginsenoside Rg3 (Rg3) is a member of the ginsenoside family of chemicals extracted from Panax ginseng. Like other ginsenosides, Rg3 has two epimers: 20(S)-ginsenoside Rg3 (SRg3) and 20(R)-ginsenoside Rg3 (RRg3).
Maryam Nakhjavani +4 more
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Ginsenoside Rg3 inhibits the malignant progression of cervical cancer cell by regulating AKT2 expression [PDF]
Heliyon, 2023 Although ginsenoside Rg3 has been shown to exert anticancer effects in various malignancies, the effects and molecular mechanisms of ginsenoside Rg3 in cervical cancer (CC) remain unclear.
Hui Liu, Tingting Xie, Yuan Liu
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Ginsenoside Rg3 ameliorates allergic airway inflammation and oxidative stress in mice
Journal of Ginseng Research, 2021 Background: Ginsenoside Rg3, isolated from Panax ginseng, has anti-inflammatory and anti-tumor activities. It is known to reduce inflammation in acute lung injury in mice, and to reduce the expression of inflammatory cytokines and COX-2 in human ...
Wen-Chung Huang +5 more
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Inhibitory effect of ginsenoside Rg3 combined with gemcitabine on angiogenesis and growth of lung cancer in mice [PDF]
BMC Cancer, 2009 Background Ginsenoside Rg3, a saponin extracted from ginseng, inhibits angiogenesis. The combination of low-dose chemotherapy and anti-angiogenic inhibitors suppresses growth of experimental tumors more effectively than conventional therapy or anti ...
Ji Ling-Ling +7 more
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Journal of Ginseng Research, 2020 Background: 20(S)-ginsenoside-Rg3 (C42H72O13), a natural triterpenoid saponin, is extracted from red ginseng. The increasing use of 20(S)-ginsenoside Rg3 has raised product safety concerns. Methods: In acute toxicity, 20(S)-ginsenoside Rg3 was singly and
Chunmei Li +12 more
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Ginsenoside Rg3 attenuates myocardial ischemia/reperfusion-induced ferroptosis via the keap1/Nrf2/GPX4 signaling pathway [PDF]
BMC Complementary Medicine and TherapiesBackground Ginsenoside Rg3 is a component of ginseng that protects against myocardial ischemia/reperfusion (MI/R) injury. Ferroptosis is a new form of cell death characterized by oxidative damage to phospholipids. The purpose of this study was to examine
GuoFu Zhong +9 more
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Conversion of Protopanaxadiol Type Saponins to Ginsenoside Rg3 by Lemon [PDF]
Natural Product Communications, 2012 The ability of fresh lemon ( Citrus limon ) to convert protopanaxadiol-type saponins into ginsenoside Rg3 was investigated, and the structures of 20( S )-ginsenoside Rg3 (1) and 20( R )-ginsenoside Rg3 (2) were identified by 1 H NMR and 13 C NMR ...
Cheng-Peng Sun +3 more
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Journal of Ginseng Research, 2015 Background: Ginsenoside Rg3 is a promising anticancer agent. It is usually produced by heat treatment of ginseng, in which ginsenoside Rb1 is the major ginsenoside.
Hoang Tung Vo +4 more
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The Pharmacological Mechanisms Underlying the Protective Effect of Ginsenoside Rg3 against Heart Failure [PDF]
Cardiology Research and PracticeBackground. Heart failure represents the terminal stage of various cardiovascular diseases. This study aims to explore the pharmacological mechanisms underlying the protective effect of Ginsenoside Rg3 against heart failure. Methods. Potential targets of
Yanan Jia, Miao Gong, Zunping Ke
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Ginsenoside Rg3 Reduces Lipid Accumulation with AMP-Activated Protein Kinase (AMPK) Activation in HepG2 Cells [PDF]
International Journal of Molecular Sciences, 2012 Cardiovascular disease (CVD) is one of the main causes of mortality worldwide, and dyslipidemia is a major risk factor for CVD. Ginseng has been widely used in the clinic to treat CVD.
Mak-Soon Lee, Chong-Tai Kim, In-Hwan Kim
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