Results 41 to 50 of about 4,987 (188)

Anticancer effects of ginsenoside Rg3 (Review)

International Journal of Molecular Medicine, 2017
Cancer is a life-threatening disease with an alarmingly increased annual mortality rate globally. Although various therapies are employed for cancer, the final effect is not satisfactory. Chemotherapy is currently the most commonly used treatment option.
Mengyao, Sun, Ying, Ye, Ling, Xiao, Xinya, Duan, Yongming, Zhang, Hong, Zhang   +5 more
openaire   +3 more sources

Ginsenoside rg3 reduces body weight by regulating fat content and browning in obese mice

Journal of Traditional Chinese Medical Sciences, 2021
Objective: To determine the effects of ginsenoside rg3 on the body weight of C57BL/6J obese mice and to investigate its underlying weight loss mechanisms with a focus on white fat browning-related factors.
Qianqian Mu, Jiacheng Zuo, Dandan Zhao, Xiaoshan Zhou, Jing Hua, Ying Bai, Fangfang Mo, Xin Fang, Min Fu, Sihua Gao   +9 more
doaj   +1 more source

Ginsenoside RG3 inhibits epithelial-mesenchymal transition of gallbladder cancer cells through PI3K/AKT/mTOR signaling pathway [PDF]

Waike lilun yu shijian
Objective To explore the specific mechanism of Ginsenoside Rg3 inhibiting gallbladder cancer (GBC)cells. Methods Cell counting kit-8(CCK-8) assay was used to examine the effect of Ginsenoside Rg3 on the viability of GBC cells.
ZHOU Xin, WANG Lubing, ZHANG Bo
doaj   +1 more source

Generation and Characterization of Monoclonal Antibody to Ginsenoside Rg3

Biological and Pharmaceutical Bulletin, 2009
While studying the mechanism of ginsenoside Rg3 (G-Rg3) on tumor inhibition, we produced monoclonal antibody to G-Rg3 for more specific investigation. We immunized Balb/c mice to G-Rg3 conjugated bovine serum albumin (BSA) by intraperitoneal injection and hybridized splenocytes from those immunized mice and myeloma cells.
Joo, Eun Ji, Ha, Young Wan, Shin, Heungsop, Son, Sung Ho, Kim, Yeong Shik   +4 more
openaire   +3 more sources

Stereospecificity of Ginsenoside Rg3 Action on Ion Channels

Molecules and Cells, 2004
Ginsenosides, active ingredients of Panax ginseng, exist as stereoisomers depending on the position of the hydroxyl group on carbon-20; i.e. 20(R)-ginsenoside and 20(S)-ginsenoside are epimers. We have shown previously that the mixture of 20(R)- and 20(S)-ginsenosides regulates ion channel activity.
Sang Min, Jeong, Jun-Ho, Lee, Jong-Hoon, Kim, Byung-Hwan, Lee, In-Soo, Yoon, Joon-Hee, Lee, Dong-Hyun, Kim, Hyewhon, Rhim, Yangmee, Kim, Seung-Yeol, Nah   +9 more
openaire   +2 more sources

Pharmacological properties, molecular mechanisms and therapeutic potential of ginsenoside Rg3 as an antioxidant and anti-inflammatory agent

Frontiers in Pharmacology, 2022
Inflammation and oxidative stress lead to various acute or chronic diseases, including pneumonia, liver and kidney injury, cardiovascular and cerebrovascular diseases, metabolic diseases, and cancer.
Jing Wang, Jing Wang, Li Zeng, Ying Zhang, Wenxiu Qi, Ziyuan Wang, Lin Tian, Daqing Zhao, Qibiao Wu, Qibiao Wu, Xiangyan Li, Tan Wang   +11 more
doaj   +1 more source

Ginsenoside RG3 Synergizes With STING Agonist to Reverse Cisplatin Resistance in Gastric Cancer. [PDF]

Food Sci Nutr
This study investigates the synergistic inhibitory effects of combining the stimulator of interferon genes (STING) agonist cyclic diadenylate monophosphate (c-di-AMP) and ginsenoside RG3 on cisplatin (DDP)-resistant gastric cancer (GC) cells.
Lu Z, Fu Y, Fu Q, Chang Y, Zhang M, Jin T.   +5 more
europepmc   +2 more sources

Ginsenoside Rg3 promotes regression from hepatic fibrosis through reducing inflammation-mediated autophagy signaling pathway

, 2020
Inflammation and autophagy occur during hepatic fibrosis development caused by various pathogens, and effectively curbing of autophage may delay the occurrence of hepatic fibrosis.
Jiang, Shuang, Wang, Zi, Hou, Jingang, Chen, Chen, Wang, Yingping, Liu, Xiangxiang, Li, Wei, Mi, Xiaojie, Zhang, Ming   +8 more
core   +1 more source

Evaluation of the gastroprotective effects of 20 (S)-ginsenoside Rg3 on gastric ulcer models in mice

Journal of Ginseng Research, 2019
Background: Gastric ulcer (GU) is a common gastrointestinal disease that can be induced by many factors. Finding an effective treatment method that contains fewer side effects is important.
Kai Zhang, Ying Liu, Cuizhu Wang, Jiannan Li, Lingxin Xiong, Zhenzhou Wang, Jinping Liu, Pingya Li   +7 more
doaj   +1 more source

Ginsenoside Rg3 for Chemotherapy-Induced Myelosuppression: A Meta-Analysis and Systematic Review

Frontiers in Pharmacology, 2020
Patients with advanced cancer often undergo myelosuppression after receiving chemotherapy. However, severe myelosuppression results in treatment delay, and some can even be life-threatening.
Linlin Pan, Tingting Zhang, Hongfu Cao, Haiyang Sun, Guirong Liu   +4 more
doaj   +1 more source