Results 61 to 70 of about 4,514 (169)

Ginsenoside Rg3 inhibits pulmonary fibrosis by preventing HIF-1α nuclear localisation

BMC Pulmonary Medicine, 2021
Background Excessive fibroblast proliferation during pulmonary fibrosis leads to structural abnormalities in lung tissue and causes hypoxia and cell injury. However, the mechanisms and effective treatment are still limited.
Zhuo Fu, Yong-sheng Xu, Chun-quan Cai
doaj   +1 more source

The Efficacy of Ginsenoside Rg3 Combined with First-line Chemotherapy in the Treatment of Advanced Non-Small Cell Lung Cancer in China: A Systematic Review and Meta-Analysis of Randomized Clinical Trials

Frontiers in Pharmacology, 2021
Background: For advanced non-small cell lung cancer (NSCLC) patients, first-line chemotherapy is the main treatment in the clinic despite its efficacy is limited and adverse effects are always inescapable.
Ze Peng, Wen Wen Wu, Ping Yi
doaj   +1 more source

Food and Medicine Homologous Plants in Osteoporosis: A Scoping Review of Preclinical Evidence

Food Science &Nutrition, Volume 14, Issue 6, June 2026.
Food and medicine homologous (FMH) plants and their bioactive compounds exhibit potential osteoprotective effects through multiple complementary mechanisms, including estrogen‐like signaling, attenuation of oxidative stress, modulation of the gut microbiota–bone axis, and regulation of autophagy.
Long Zhao, Xiao‐li Dong, Rui‐ting Li, Qu‐huan Ma, Xiao‐feng Shi   +4 more
wiley   +1 more source

Machine Learning‐Driven Predictive Modeling and Multi‐Objective Exploration of Oxaliplatin‐Loaded Nanocarriers for Enhanced Loading and Encapsulation Efficiency

Materials Genome Engineering Advances, Volume 4, Issue 2, June 2026.
Integrating ML and multi‐objective optimization enabled efficient, accurate design of nanocarriers with optimized loading and encapsulation efficiencies. ABSTRACT Oxaliplatin (OXA), a critical third‐generation platinum chemotherapeutic, is significantly limited by suboptimal loading capacity and encapsulation efficiency in nanoparticle‐based delivery ...
Abbas Rahdar, Maryam Shirzad, Sonia Fathi‐Karkan, M. Ali Aboudzadeh   +3 more
wiley   +1 more source

Formulation and Pharmacological Evaluation of a Medicine‐Food Homology Herb‐Based Formula for Sleep Enhancement

Phytochemicals in Food and Medicine, Volume 1, Issue 2, June 2026.
This outlines the progress for developing a sleep‐modulating herbal formula (SMF). It begins with the identification of effective compounds and quality control, then uses network pharmacology and molecular docking to explain the mechanisms behind the observation found on the behavioural and neurobiological results in animal study.
Jasmine U. Ting, Chunxue Zhao, Jia Xu, Chenrui Liu, Yungang Tian, Min Ye, Tao Cui, Jian Huang   +7 more
wiley   +1 more source

Chromosome‐Level Genome Assembly of the Allotetraploid Gynostemma pentaphyllum Provides Novel Insights Into the Biosynthesis of Ginsenoside and Gypenoside LVI

Plant Biotechnology Journal, Volume 24, Issue 6, Page 4204-4220, June 2026.
ABSTRACT Gynostemma pentaphyllum, a herb used in tea and traditional Chinese medicine, shows geographic variation in its production of valuable dammarane‐type ginsenosides and gypenoside LVI between populations from Suining (SN) and Nanning (NN). To elucidate the mechanisms underlying this differential metabolite accumulation, a chromosome‐level genome
Peina Zhou, Si‐Jie Liu, Lijin Huang, Yingping Wang, Xinyu Jiang, Wang Dong, Jianfeng Gong, Long Wang, Yuyin Zhao, Huiying Wang, Ping Li, Jia‐Yu Xue, Xu Lu   +12 more
wiley   +1 more source

Emerging Role of Panax ginseng in the Management of Cancer: Phytochemistry, SAR, Therapeutic Potential, and Clinical Aspects

Food Frontiers, Volume 7, Issue 3, May 2026.
This review aims to provide a comprehensive understanding of the therapeutic potential of bioactive anticancer phytoconstituents in Panax ginseng, including their clinical aspects and SAR, thereby fostering the development of newer anticancer compounds for cancer management.
Akrit Verma, Sanjeev Kumar Sahu, Anil Kumar Sah   +2 more
wiley   +1 more source

Inhibitory effect of ginsenoside Rg3 combined with gemcitabine on angiogenesis and growth of lung cancer in mice

BMC Cancer, 2009
Background Ginsenoside Rg3, a saponin extracted from ginseng, inhibits angiogenesis. The combination of low-dose chemotherapy and anti-angiogenic inhibitors suppresses growth of experimental tumors more effectively than conventional therapy or anti ...
Ji Ling-Ling, Mao Shu-Hua, Huang Xiao-Bing, Cui Dan-Dan, Huang Ying, Liu Tai-Guo, Song Hai-Bo, Yi Cheng   +7 more
doaj   +1 more source

Unveiling the experimental proof of the anticancer potential of ginsenoside Rg3 (Review). [PDF]

Oncol Lett
Ginsenoside Rg3 (GS-Rg3), a sterol molecule isolated from ginseng, has demonstrated various immunological properties, including inhibition of cancer cell proliferation and metastasis, reversal of drug resistance and enhancement of chemotherapy sensitivity.
Liu Y, Li G, Ning J, Zhao Y.
europepmc   +3 more sources

Molecular signaling of ginsenosides Rb1, Rg1, and Rg3 and their mode of actions

Journal of Ginseng Research, 2018
Ginseng has gained its popularity as an adaptogen since ancient days because of its triterpenoid saponins, known as ginsenosides. These triterpenoid saponins are unique and classified as protopanaxatriol and protopanaxadiol saponins based on their glycosylation patterns.
Padmanaban Mohanan, Sathiyamoorthy Subramaniyam, Ramya Mathiyalagan, Deok-Chun Yang   +3 more
openaire   +3 more sources