Results 61 to 70 of about 4,987 (188)

Comparative analysis of the expression level of recombinant ginsenoside-transforming β-glucosidase in GRAS hosts and mass production of the ginsenoside Rh2-Mix. [PDF]

PLoS ONE, 2017
The ginsenoside Rh2, a pharmaceutically active component of ginseng, is known to have anticancer and antitumor effects. However, white ginseng and red ginseng have extremely low concentrations of Rh2 or Rh2-Mix [20(S)-Rh2, 20(R)-Rh2, Rk2, and Rh3].
Muhammad Zubair Siddiqi, Chang-Hao Cui, Seul-Ki Park, Nam Soo Han, Sun-Chang Kim, Wan-Taek Im   +5 more
doaj   +1 more source

Food and Medicine Homologous Plants in Osteoporosis: A Scoping Review of Preclinical Evidence

Food Science &Nutrition, Volume 14, Issue 6, June 2026.
Food and medicine homologous (FMH) plants and their bioactive compounds exhibit potential osteoprotective effects through multiple complementary mechanisms, including estrogen‐like signaling, attenuation of oxidative stress, modulation of the gut microbiota–bone axis, and regulation of autophagy.
Long Zhao, Xiao‐li Dong, Rui‐ting Li, Qu‐huan Ma, Xiao‐feng Shi   +4 more
wiley   +1 more source

Bioactivity-guided isolation of ginsenosides from Korean Red Ginseng with cytotoxic activity against human lung adenocarcinoma cells

Journal of Ginseng Research, 2018
Background: Lung cancer is the leading cause of cancer-related death worldwide. In this study, we used a bioactivity-guided isolation technique to identify constituents of Korean Red Ginseng (KRG) with antiproliferative activity against human lung ...
Jae Sik Yu, Hyun-Soo Roh, Kwan-Hyuck Baek, Seul Lee, Sil Kim, Hae Min So, Eunjung Moon, Changhyun Pang, Tae Su Jang, Ki Hyun Kim   +9 more
doaj   +1 more source

Exploration and Characterization of Novel Glycoside Hydrolases from the Whole Genome of Lactobacillus ginsenosidimutans and Enriched Production of Minor Ginsenoside Rg3(S) by a Recombinant Enzymatic Process

Biomolecules, 2020
Background: Several studies have reported that ginsenoside Rg3(S) is effective in treating metastatic diseases, obesity, and various cancers, however, its presence in white ginseng cannot be estimated, and only a limited amount is present in red ginseng.
Muhammad Zubair Siddiqi, Sathiyaraj Srinivasan, Hye Yoon Park, Wan-Taek Im   +3 more
doaj   +1 more source

Ginsenoside Rg3 Ameliorates Stress of Broiler Chicks Induced by Escherichia coli Lipopolysaccharide

Frontiers in Veterinary Science, 2022
In broiler chicks, Escherichia coli lipopolysaccharide is a prominent cause for inflammatory damage and loss of immune homeostasis in broiler chicks. Ginsenosides have been shown to have anti-inflammatory and antioxidant effects. However, it has not been
Shicheng Bi, Yiwen Qu, Jianjian Shao, Jianrong Zhang, Weihao Li, Li Zhang, Jingxuan Ni, Liting Cao   +7 more
doaj   +1 more source

Ginsenoside Rg3, a Gating Modifier of EAG Family K+ Channels [PDF]

Molecular Pharmacology, 2016
Ginsenoside 20(S)-Rg3 (Rg3) is a steroid glycoside that induces human ether-à-go-go-related gene type 1 (hERG1, Kv11.1) channels to activate at more negative potentials and to deactivate more slowly than normal. However, it is unknown whether this action is unique to hERG1 channels. Here we compare and contrast the mechanisms of actions of Rg3 on hERG1
Wei, Wu, Alison, Gardner, Frank B, Sachse, Michael C, Sanguinetti   +3 more
openaire   +2 more sources

Inhibitory effect of ginsenoside Rg3 on ovarian cancer metastasis

Chinese Medical Journal, 2008
Ginsenosides are main components extracted from ginseng, and ginsenoside Rg3 is one of the most important parts. Ginsenoside Rg3 has been found to inhibit several kinds of tumor growth and metastasis. The present study was undertaken to investigate the effect of ginsenoside Rg3 on human ovarian cancer metastasis and the possible mechanism.The ...
Tian-Min, Xu, Man-Hua, Cui, Ying, Xin, Li-Ping, Gu, Xin, Jiang, Man-Man, Su, Ding-Ding, Wang, Wen-Jia, Wang   +7 more
openaire   +2 more sources

Ginsenoside Rg3 inhibits pulmonary fibrosis by preventing HIF-1α nuclear localisation

BMC Pulmonary Medicine, 2021
Background Excessive fibroblast proliferation during pulmonary fibrosis leads to structural abnormalities in lung tissue and causes hypoxia and cell injury. However, the mechanisms and effective treatment are still limited.
Zhuo Fu, Yong-sheng Xu, Chun-quan Cai
doaj   +1 more source

Machine Learning‐Driven Predictive Modeling and Multi‐Objective Exploration of Oxaliplatin‐Loaded Nanocarriers for Enhanced Loading and Encapsulation Efficiency

Materials Genome Engineering Advances, Volume 4, Issue 2, June 2026.
Integrating ML and multi‐objective optimization enabled efficient, accurate design of nanocarriers with optimized loading and encapsulation efficiencies. ABSTRACT Oxaliplatin (OXA), a critical third‐generation platinum chemotherapeutic, is significantly limited by suboptimal loading capacity and encapsulation efficiency in nanoparticle‐based delivery ...
Abbas Rahdar, Maryam Shirzad, Sonia Fathi‐Karkan, M. Ali Aboudzadeh   +3 more
wiley   +1 more source

Formulation and Pharmacological Evaluation of a Medicine‐Food Homology Herb‐Based Formula for Sleep Enhancement

Phytochemicals in Food and Medicine, Volume 1, Issue 2, June 2026.
This outlines the progress for developing a sleep‐modulating herbal formula (SMF). It begins with the identification of effective compounds and quality control, then uses network pharmacology and molecular docking to explain the mechanisms behind the observation found on the behavioural and neurobiological results in animal study.
Jasmine U. Ting, Chunxue Zhao, Jia Xu, Chenrui Liu, Yungang Tian, Min Ye, Tao Cui, Jian Huang   +7 more
wiley   +1 more source