Results 81 to 90 of about 4,987 (188)

Ginsenoside Rg3 ameliorated HFD-induced hepatic steatosis through downregulation of STAT5-PPARγ

, 2017
Healthy expansion of adipose tissue maintains metabolic homeostasis by storing excess chemical energy in increased fat mass. The STAT5-PPAR gamma pathway reportedly regulates adipocyte differentiation, lipid metabolism and adipogenesis.
S W Chung, Jeong Ki Min, Haiyoung Jung, Inpyo Choi, Jeong-Ki Min, I S Kim, Ik-Soo Kim, Suk Ran Yoon, Su Wol Chung, Sung-Jin Yoon, Sang-Hyun Lee, Sung Jin Yoon, Moo-Seung Lee, Sang Hyun Lee, Hee Gu Lee, Jin-Bong Lee, Young-Jun Park, Tae-Don Kim   +17 more
core   +1 more source

Microneedle Technology in Psoriasis Management: Mechanistic Insights, Technological Innovation, Clinical Progress, and Challenges

Advanced Healthcare Materials, Volume 15, Issue 10, 13 March 2026.
This review explores the evolving role of microneedle systems in psoriasis management, highlighting their potential for enhanced drug delivery, diagnosis, and disease monitoring. It also discusses unmet clinical needs for psoriasis management and technical challenges, while outlining strategic directions to advance microneedle integration into routine ...
Fatma Moawad, Yasmine Ruel, Roxane Pouliot, Davide Brambilla   +3 more
wiley   +1 more source

Unveiling the experimental proof of the anticancer potential of ginsenoside Rg3 (Review). [PDF]

Oncol Lett
Ginsenoside Rg3 (GS-Rg3), a sterol molecule isolated from ginseng, has demonstrated various immunological properties, including inhibition of cancer cell proliferation and metastasis, reversal of drug resistance and enhancement of chemotherapy sensitivity.
Liu Y, Li G, Ning J, Zhao Y.
europepmc   +3 more sources

Targeting Autophagy in Ovarian Cancer: The Emerging Role of Ginsenosides

Cancer Medicine, Volume 15, Issue 3, March 2026.
ABSTRACT Background Ovarian cancer, the third most prevalent gynecological malignancy, is frequently diagnosed at an advanced stage owing to its asymptomatic early progression. Despite the application of conventional therapies, clinical management remains limited by adverse effects and the development of drug resistance.
Yuxin Guo, Cuilan Yun, Yuemei Zhang, Xu Yang, Huiqin Liu   +4 more
wiley   +1 more source

Effects of ginsenoside Rg3 on epigenetic modification in ovarian cancer cells

Oncology Reports, 2019
Epigenetic modifications are closely related to oncogene activation and tumor suppressor gene inactivation. The aim of this study was to determine the effects of ginsenoside Rg3 on epigenetic modification in ovarian cancer cells. Cell proliferation, metastasis, invasion and apoptosis were respectively determined using Cell Counting Kit‑8 (CCK‑8), wound
Zhao, Lingqin, Shou, Huafeng, Chen, Lu, Gao, Wen, Fang, Chenyan, Zhang, Ping   +5 more
openaire   +3 more sources

Synergistic effects of ginsenoside Rg3 and cyclophosphamine on tumor growth and angiogenesis in lung cancer

, 2013
To evaluate the effectiveness of ginsenoside Rg3 alone or in combination with cyclophosphamide (CPA) on tumor growth and angiogenesis in human lung cancer, 54 female athymic mice were transplanted with lung cancer cells (A549) which then were randomly ...
Hang, L, Meihua, C, Shengping, Z, Chenyu, W, Wenjun, Y, Jing, J, Jun, W, Yanfeng, G, Aiying, AS, Qishan, M   +9 more
core   +1 more source

20(S)-ginsenoside Rg3 promotes senescence and apoptosis in gallbladder cancer cells via the p53 pathway

, 2015
Fei Zhang,* Maolan Li,* Xiangsong Wu,* Yunping Hu, Yang Cao, Xu’an Wang, Shanshan Xiang, Huaifeng Li, Lin Jiang, Zhujun Tan, Wei Lu, Hao Weng, Yijun Shu, Wei Gong, Xuefeng Wang, Yong Zhang, Weibin Shi, Ping Dong,# Jun Gu,# Yingbin Liu#Department of
Zhang F, Li H, Jiang L, Hu Y, Lu W, Xiang S, Shi W, Dong P, Li M, Gong W, Liu Y, Tan Z, Zhang Y, Cao Y, Weng H, Gu J, Wang X, Shu Y, Wu X   +18 more
core  

Hot Water Extraction of Korean Red Ginseng (Panax ginseng C.A. Meyer) Using Vacuum‐Gas Substitution Under Oxygen‐Free Conditions: Effect on Ginsenosides and Antioxidant Activity

Journal of Food Science, Volume 91, Issue 3, March 2026.
ABSTRACT This study investigated the effect of a vacuum‐gas substitution hot water extraction (HWE) process on Korean red ginseng (KRG) using a specially designed device. The yield, browning, antioxidant activity, and ginsenoside content of KRG extracted under oxygen‐free conditions (OFC, dissolved oxygen: 0.47 mg/L) were compared with those extracted ...
Kyo‐Yeon Lee, Hee‐Su Yoon, Sung‐Gil Choi   +2 more
wiley   +1 more source

Surface‐Coated Inorganic Nanomaterials for Drug Delivery: Chemical Design, Biomedical Applications, and Mechanistic Insights

Advanced NanoBiomed Research, Volume 6, Issue 2, February 2026.
This review explores how surface‐coated inorganic nanomaterials are chemically engineered for advanced drug delivery. It highlights design principles, coating strategies, and biomedical applications, emphasizing how surface chemistry governs biocompatibility, targeting, and controlled release.
Hossein Daneshgar, Sepideh Ahmadi, Nikzad Abbariki, Navid Rabiee, Sidi A. Bencherif   +4 more
wiley   +1 more source

Ginsenoside Rg1 as a Multifunctional Therapeutic Agent: Pharmacological Properties, Molecular Mechanisms and Clinical Perspectives in Complementary Medicine

Food Science &Nutrition, Volume 14, Issue 2, February 2026.
Ginsenoside Rg1 (Rg1) from Panax ginseng shows multifunctional health effects. Although oral bioavailability is low and blood–brain barrier (BBB) penetration is limited, delivery systems such as liposomes and nanoparticles may improve exposure. Rg1 reduces inflammation/oxidative stress by inhibiting nuclear factor‐κB (NF‐κB) signaling and reactive ...
Hernán Cortés, Enrique Lima, Lorena Duarte‐Peña, Sheila I. Peña‐Corona, Zainab M. Almarhoon, Rajesh Kaverikana, Shivaprasad Shetty Mangalpady, Vinayaka Babu Shet, Nikshitha Manjeshwar, Javad Sharifi‐Rad, Jen‐Tsung Chen, Gerardo Leyva‐Gómez, William N. Setzer, Daniela Calina   +13 more
wiley   +1 more source