Results 71 to 80 of about 4,514 (169)

Beneficial effects of fermented black ginseng and its ginsenoside 20(S)-Rg3 against cisplatin-induced nephrotoxicity in LLC-PK1 cells

Journal of Ginseng Research, 2016
Background: Nephrotoxicity is a common side effect of medications. Panax ginseng is one of the best-known herbal medicines, and its individual constituents enhance renal function.
Myoung-Sik Han, Im-Ho Han, Dahae Lee, Jun Min An, Su-Nam Kim, Myoung-Sook Shin, Noriko Yamabe, Gwi Seo Hwang, Hye Hyun Yoo, Suk-Jung Choi, Ki Sung Kang, Hyuk-Jai Jang   +11 more
doaj   +1 more source

Advanced Corneal Hydrogels: From Passive Replacement to Active Regeneration and Intelligent Interaction

Advanced Science, Volume 13, Issue 19, 2 April 2026.
This review charts the evolution of corneal hydrogels from passive replacements to active and intelligent systems, evaluating natural and synthetic materials while addressing design challenges such as transparency and strength. Advanced applications such as scarless wound healing, three‐dimensional bioprinting, and smart wearables are highlighted to ...
Xinwei Wang, Wen Zhou, Haotian Xue, Wenjun Xue, Guangping Gao, Bing Zhu, Hongyuan Song, Qingqiang Xu, Jing Zhao, Wei Shen   +9 more
wiley   +1 more source

Pharmacological Inhibition of APT2 by Solasonine Promotes Ferroptosis Through Palmitoylation Modulation in Gallbladder Cancer

Phytotherapy Research, Volume 40, Issue 4, Page 1642-1660, April 2026.
Schematic illustration of SS‐induced ferroptosis through targeting APT2‐mediated STAT3 palmitoylation in GBC cells. ABSTRACT Gallbladder cancer (GBC), the most prevalent and lethal biliary tract malignancy, lacks effective therapeutic strategies. Solasonine (SS), a bioactive steroidal alkaloid derived from Solanum nigrum L, exhibits antitumor activity ...
Liu‐qing Shi, Jing‐wei Zhao, Jia‐yun Zhu, Cheng Zhao, Zi‐yi Yang, Li‐jia Pan, Ben Ma, Zheng‐yu Chen, Zi‐ying Wang, Chun‐jie Li, Shi‐lei Liu, Jia‐wei Mei, Ping Dong   +12 more
wiley   +1 more source

Stereoselective Anti-Cancer Activities of Ginsenoside Rg3 on Triple Negative Breast Cancer Cell Models

Pharmaceuticals, 2019
Ginsenoside Rg3 (Rg3) has two epimers, 20(S)-ginsenoside Rg3 (SRg3) and 20(R)-ginsenoside Rg3 (RRg3), and while Rg3 itself has been reported to have anti-cancer properties, few studies have been reported on the anti-cancer effects of the different ...
Maryam Nakhjavani, Helen M. Palethorpe, Yoko Tomita, Eric Smith, Timothy J. Price, Andrea J. Yool, Jinxin V. Pei, Amanda R. Townsend, Jennifer E. Hardingham   +8 more
doaj   +1 more source

Microneedle Technology in Psoriasis Management: Mechanistic Insights, Technological Innovation, Clinical Progress, and Challenges

Advanced Healthcare Materials, Volume 15, Issue 10, 13 March 2026.
This review explores the evolving role of microneedle systems in psoriasis management, highlighting their potential for enhanced drug delivery, diagnosis, and disease monitoring. It also discusses unmet clinical needs for psoriasis management and technical challenges, while outlining strategic directions to advance microneedle integration into routine ...
Fatma Moawad, Yasmine Ruel, Roxane Pouliot, Davide Brambilla   +3 more
wiley   +1 more source

Influence of type and proportion of lyoprotectants on lyophilized ginsenoside Rg3 liposomes

Journal of Pharmacy and Pharmacology, 2016
Abstract Objectives To improve stability and shelf life, lyophilized formulations of 20(R)-Ginsenoside Rg3 liposomes (G-Rg3-Ls) were prepared. Methods Glucose, trehalose, sucrose, maltose, lactose, mannitol, inositol, hydroxypropyl-β ...
Jianying, Li, Meina, Hu, Huan, Xu, Xiu, Yu, Feifei, Ye, Kaiqian, Wang, Xiaojiao, Luan, Ling, Li, Di, Zhang   +8 more
openaire   +2 more sources

The protective role of ginsenoside Rg3 in heart diseases and mental disorders. [PDF]

Front Pharmacol
Ginsenoside Rg3, a compound derived from Panax ginseng C. A. Mey., is increasingly recognized for its wide range of pharmacological effects. Under the worldwide healthcare challenges posed by heart diseases, Rg3 stands out as a key subject in modern research on Chinese herbal medicine, offering a novel approach to therapy.
Shi L, Luo J, Wei X, Xu X, Tu L.
europepmc   +4 more sources

Ginsenoside Rg3 Mitigates Atherosclerosis Progression in Diabetic apoE–/– Mice by Skewing Macrophages to the M2 Phenotype

Frontiers in Pharmacology, 2018
Atherosclerosis (AS) in diabetic patients is often associated with low stability, which might be largely attributed to unfavorable macrophage polarization and increased inflammatory response induced by hyperglycaemia.
Mengqi Guo, Jie Xiao, Xi Sheng, Xinyu Zhang, Yuanyuan Tie, Lei Wang, Lang Zhao, Xiaoping Ji   +7 more
doaj   +1 more source

Simultaneous determination of 3 kinds of rare ginsenosides in fermented ginseng by HPLC [PDF]

Zhongguo niangzao
A method for simultaneous determination of 3 kinds of rare ginsenoside Rg3, Rg3(R) and Rg5 in fermented ginseng by HPLC was established. The samples were separated by Xtimate-C18 (4.6 mm×250 mm, 5 μm) using acetonitrile and 0.1% phosphoric acid ...
LI Chunyang, CHENG Qian, CHEN Zhao, WANG Tao, PENG Ning, CHEN Zhixian
doaj   +1 more source

Effects of ginsenoside Rg3 on epigenetic modification in ovarian cancer cells

Oncology Reports, 2019
Epigenetic modifications are closely related to oncogene activation and tumor suppressor gene inactivation. The aim of this study was to determine the effects of ginsenoside Rg3 on epigenetic modification in ovarian cancer cells. Cell proliferation, metastasis, invasion and apoptosis were respectively determined using Cell Counting Kit‑8 (CCK‑8), wound
Zhao, Lingqin, Shou, Huafeng, Chen, Lu, Gao, Wen, Fang, Chenyan, Zhang, Ping   +5 more
openaire   +3 more sources