Results 21 to 30 of about 4,987 (188)

Ginsenoside Rg3 Attenuates Lipopolysaccharide-Induced Acute Lung Injury via MerTK-Dependent Activation of the PI3K/AKT/mTOR Pathway [PDF]

open access: yesFrontiers in Pharmacology, 2018
Acute lung injury (ALI) is a common clinical disease with high morbidity in both humans and animals. Ginsenoside Rg3, a type of traditional Chinese medicine extracted from ginseng, is widely used to cure many inflammation-related diseases.
Jing Yang   +7 more
doaj   +2 more sources

Protective effects of 20(R) ginsenoside Rg3 on DBP-induced reproductive injury in mice through Nrf2/ARE pathway [PDF]

open access: yesScientific Reports
Di-n-butyl phthalate (DBP), an environmental endocrine disruptor, can induce male reproductive dysfunction. In the study, the protective mechanism of ginsenoside Rg3 (Rg3) against DBP-induced damage to spermatogenic function was explored through the Nrf2/
Huan Li   +5 more
doaj   +2 more sources

Ginsenoside Rg3 Mitigates Atherosclerosis Progression in Diabetic apoE–/– Mice by Skewing Macrophages to the M2 Phenotype

open access: yesFrontiers in Pharmacology, 2018
Atherosclerosis (AS) in diabetic patients is often associated with low stability, which might be largely attributed to unfavorable macrophage polarization and increased inflammatory response induced by hyperglycaemia.
Mengqi Guo   +7 more
doaj   +2 more sources

Stereoselective Anti-Cancer Activities of Ginsenoside Rg3 on Triple Negative Breast Cancer Cell Models

open access: yesPharmaceuticals, 2019
Ginsenoside Rg3 (Rg3) has two epimers, 20(S)-ginsenoside Rg3 (SRg3) and 20(R)-ginsenoside Rg3 (RRg3), and while Rg3 itself has been reported to have anti-cancer properties, few studies have been reported on the anti-cancer effects of the different ...
Maryam Nakhjavani   +8 more
doaj   +2 more sources

Ginsenoside Rg3 Suppresses Proliferation and Induces Apoptosis in Human Osteosarcoma [PDF]

open access: yesBioMed Research International, 2018
Osteosarcoma is the most common primary malignancy of bone in children and the elderly. Recently, more and more researches have demonstrated that Ginsenoside Rg3 (Rg3) is involved in chemotherapy resistance in many cancer, making it a promising Chinese herbal monomer for oncotherapy.
Yi Li   +5 more
openaire   +3 more sources

Beneficial effects of fermented black ginseng and its ginsenoside 20(S)-Rg3 against cisplatin-induced nephrotoxicity in LLC-PK1 cells

open access: yesJournal of Ginseng Research, 2016
Background: Nephrotoxicity is a common side effect of medications. Panax ginseng is one of the best-known herbal medicines, and its individual constituents enhance renal function.
Myoung-Sik Han   +11 more
doaj   +2 more sources

Inhibitory effect of ginsenoside Rg3 combined with gemcitabine on angiogenesis and growth of lung cancer in mice

open access: yesBMC Cancer, 2009
Background Ginsenoside Rg3, a saponin extracted from ginseng, inhibits angiogenesis. The combination of low-dose chemotherapy and anti-angiogenic inhibitors suppresses growth of experimental tumors more effectively than conventional therapy or anti ...
Ji Ling-Ling   +7 more
doaj   +2 more sources

Ginsenoside Rg3 suppresses mast cell–mediated allergic inflammation via mitogen-activated protein kinase signaling pathway

open access: yesJournal of Ginseng Research, 2019
Background: Ginsenoside Rg3 (G-Rg3) is the major bioactive ingredient of Panax ginseng and has many pharmacological effects, including antiadipogenic, antiviral, and anticancer effects.
Ji-Ye Kee, Seung-Heon Hong
doaj   +2 more sources

Ginsenoside Rg3-enriched red ginseng extract inhibits platelet activation and in vivo thrombus formation

open access: yesJournal of Ginseng Research, 2017
Background: Korean Red Ginseng has been used for several decades to treat many diseases, enhancing both immunity and physical strength. Previous studies have documented the therapeutic effects of ginseng, including its anticancer, antiaging, and anti ...
Dahye Jeong   +7 more
doaj   +2 more sources

Ginsenoside Rg3 Protects against Diabetic Cardiomyopathy and Promotes Adiponectin Signaling via Activation of PPAR-γ. [PDF]

open access: yesInt J Mol Sci, 2023
Ginsenoside Rg3 extracted from Panax notoginseng has therapeutic effects on diabetes and heart diseases. However, the underlying mechanism of ginsenoside Rg3 on diabetic cardiomyopathy (DCM) remains unclear.
Zhang C   +5 more
europepmc   +2 more sources

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