Results 21 to 30 of about 8,812 (152)

Beneficial effects of fermented black ginseng and its ginsenoside 20(S)-Rg3 against cisplatin-induced nephrotoxicity in LLC-PK1 cells [PDF]

Journal of Ginseng Research, 2016
Background: Nephrotoxicity is a common side effect of medications. Panax ginseng is one of the best-known herbal medicines, and its individual constituents enhance renal function.
Myoung-Sik Han, Im-Ho Han, Dahae Lee, Jun Min An, Su-Nam Kim, Myoung-Sook Shin, Noriko Yamabe, Gwi Seo Hwang, Hye Hyun Yoo, Suk-Jung Choi, Ki Sung Kang, Hyuk-Jai Jang   +11 more
doaj   +2 more sources

Ginsenoside Rg3 suppresses mast cell–mediated allergic inflammation via mitogen-activated protein kinase signaling pathway

Journal of Ginseng Research, 2019
Background: Ginsenoside Rg3 (G-Rg3) is the major bioactive ingredient of Panax ginseng and has many pharmacological effects, including antiadipogenic, antiviral, and anticancer effects.
Ji-Ye Kee, Seung-Heon Hong
doaj   +2 more sources

Ginsenoside Rg3-enriched red ginseng extract inhibits platelet activation and in vivo thrombus formation

Journal of Ginseng Research, 2017
Background: Korean Red Ginseng has been used for several decades to treat many diseases, enhancing both immunity and physical strength. Previous studies have documented the therapeutic effects of ginseng, including its anticancer, antiaging, and anti ...
Dahye Jeong, Muhammad Irfan, Sung-Dae Kim, Suk Kim, Jun-Hwan Oh, Chae-Kyu Park, Hyun-Kyoung Kim, Man Hee Rhee   +7 more
doaj   +2 more sources

Polymer-Based Wound Dressings Loaded with Ginsenoside Rg3. [PDF]

Molecules, 2023
The skin, the largest organ in the human body, mainly plays a protective role. Once damaged, it can lead to acute or chronic wounds. Wound healing involves a series of complex physiological processes that require ideal wound dressings to promote it.
Yang J, Zhang L, Peng X, Zhang S, Sun S, Ding Q, Ding C, Liu W.   +7 more
europepmc   +2 more sources

Ginsenoside Rg3 ameliorates myocardial glucose metabolism and insulin resistance via activating the AMPK signaling pathway

Journal of Ginseng Research, 2022
Background: Ginsenoside Rg3 is one of the main active ingredients in ginseng. Here, we aimed to confirm its protective effect on the heart function in transverse aortic coarctation (TAC)-induced heart failure mice and explore the potential molecular ...
Jingyu Ni, Zhihao Liu, Miaomiao Jiang, Lan Li, Jie Deng, Xiaodan Wang, Jing Su, Yan Zhu, Feng He, Jingyuan Mao, Xiumei Gao, Guanwei Fan   +11 more
doaj   +1 more source

Ginsenoside Rg3 attenuates fat accumulation in zebrafish with high-fat-diet-induced obesity

Pharmacological Research - Modern Chinese Medicine, 2022
Ginsenoside Rg3 is one of major steroidal saponins in Panax ginseng that has demonstrated several therapeutic effects. In this study, we investigated the effects of ginsenoside Rg3 on lipid accumulation in a high-fat diet (HFD) larval zebrafish model by ...
Fei Li, Xin Sui, Renwen Zhang, Qiuting Huang, Ying Xie   +4 more
doaj   +1 more source

Ginsenoside Rg3 Alleviates Cisplatin Resistance of Gastric Cancer Cells Through Inhibiting SOX2 and the PI3K/Akt/mTOR Signaling Axis by Up-Regulating miR-429

Frontiers in Genetics, 2022
Platinum-based cytotoxic chemotherapy is considered the standard treatment for advanced gastric cancer (GC). However, cisplatin chemoresistance often occurs with the mechanisms being not well clarified, which results in the cancer recurrence and poor ...
Xiaofeng Wang, Rui He, Li Geng, Jing Yuan, Huijie Fan   +4 more
doaj   +1 more source

Pharmacokinetic Profiling of Ginsenosides, Rb1, Rd, and Rg3, in Mice with Antibiotic-Induced Gut Microbiota Alterations: Implications for Variability in the Therapeutic Efficacy of Red Ginseng Extracts

Foods, 2023
Ginsenoside Rg3 is reported to contribute to the traditionally known diverse effects of red ginseng extracts. Significant individual variations in the therapeutic efficacy of red ginseng extracts have been reported.
Jeon-Kyung Kim, Min Sun Choi, Hee-Seo Park, Kyung Hwa Kee, Dong-Hyun Kim, Hye Hyun Yoo   +5 more
doaj   +1 more source

Co-treatment with Ginsenoside 20(S)-Rg3 and Curcumin increases Radiosensitivity of MDA-MB-231 Cancer Cell Line [PDF]

Iranian Journal of Medical Sciences, 2021
Background: Breast cancer is the second most common cancer in women worldwide. Developing drugs increase the radiosensitivity effect of tumoral tissue, while protecting normal tissues has gained much attention.
Vahid Changizi, Vahideh Gharekhani, Elaheh Motavaseli   +2 more
doaj   +1 more source

20(R)-ginsenoside Rg3, a product of high-efficiency thermal deglycosylation of ginsenoside Rd, exerts protective effects against scrotal heat-induced spermatogenic damage in mice

, 2021
Heat stress (HS) reaction can lead to serious physiological dysfunction associated with cardiovascular and various organ diseases. Ginsenoside Rg3 (G-Rg3) is a representative component of ginseng rare saponin and can protect against multiple organs, also
Wang, Z, Gong, X, Wang, Y, Leng, J, Liu, W, Zhang, R, Li, W, Chen, C, Ren, S, Wei, H   +9 more
core   +1 more source