Results 31 to 40 of about 5,667 (130)

Molecular descriptor driven QSPR modeling of Papp, TEER and Efflux Ratio from Caco‐2 cells using machine learning for various phytochemicals

Journal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND The present study aimed to develop and validate quantitative structure–property relationship (QSPR) models for predicting permeability related bioavailability indicators including apparent permeability (Papp), trans‐epithelial electrical resistance (TEER) and efflux ratio (ER) based on molecular descriptors (n = 5003) of 83 ...
Jin‐Woo Kim, Rixing Cong, Jin‐Soo Park, Keunwan Park, Kyungsu Kang, Soon‐Mi Shim   +5 more
wiley   +1 more source

Ginsenoside Rb1 Attenuates Agonist-Induced Contractile Response via Inhibition of Store-Operated Calcium Entry in Pulmonary Arteries of Normal and Pulmonary Hypertensive Rats

Cellular Physiology and Biochemistry, 2015
Background: Pulmonary hypertension (PH) is characterized by sustained vasoconstriction, enhanced vasoreactivity and vascular remodeling, which leads to right heart failure and death.
Rui-Xing Wang, Rui-Lan He, Hai-Xia Jiao, Mao Dai, Yun-Ping Mu, Ying Hu, Zhi-Juan Wu, James S.K. Sham, Mo-Jun Lin   +8 more
doaj   +1 more source

Harnessing Natural Compounds in Psoriasis: Targeting Cellular Pathways for Effective Therapy

Phytotherapy Research, EarlyView.
Natural compounds act on key cellular pathways in psoriasis by suppressing keratinocyte hyperproliferation, modulating Th17/IL‐17‐mediated immune responses, and reducing oxidative stress. These multi‐target effects highlight their potential as safer adjunctive therapies alongside conventional treatments.
Hye Jin Lee, Yu Jin So, Il‐Joo Jo, Ji Yong Jang, Tae Han Yook, Jun Ho Lee, Sung Wook Kim, Kangwook Lee, Soo Jung Park, Gabsik Yang   +9 more
wiley   +1 more source

Effect of a soluble prebiotic fiber, NUTRIOSE, on the absorption of ginsenoside Rd in rats orally administered ginseng

Journal of Ginseng Research, 2014
Background: There is limited understanding of the effect of dietary components on the absorption of ginsenosides and their metabolites into the blood. Methods: This study investigated the pharmacokinetics of the ginseng extract and its main constituent ...
Kyung-Ah Kim, Hye Hyun Yoo, Wan Gu, Dae-Hyung Yu, Ming Ji Jin, Hae-Lim Choi, Kathy Yuan, Laetitia Guerin-Deremaux, Dong-Hyun Kim   +8 more
doaj   +1 more source

Biomaterial‐Integrated Electroporation for Therapeutic Delivery: From Gene Editing to Tumor Ablation and Immune Modulation

Small, EarlyView.
Biomaterial‐integrated electroporation establishes a programmable therapeutic interface that coordinates electric‐field modulation, transient or irreversible membrane permeabilization, cargo stabilization, and immune remodeling. This Review highlights how nanocarriers, hydrogels, and bioelectronic interfaces expand electroporation from conventional ...
Binbin Ji, Zhuozhuo Wu, Yuyue Jiang, Xiaoyu Liu, Jingfeng Li, Fengkuo Xu, Chaojie Li, Qungang Shan, Ziyin Wang, Junhao Wang, Wei Huang, Yaping Zhuang, Wenguo Cui, Zhongmin Wang   +13 more
wiley   +1 more source

Ginsenoside Content of Berries and Roots of Three Typical Korean Ginseng () Cultivars

Natural Product Communications, 2009
The ginsenoside content of berries and roots of three cultivars of Korean ginseng have been investigated. For all cultivars, ginsenoside Re was the most abundant ginsenoside in roots and berries.
Yong Kyoung Kim, Dae Seok Yoo, Hui Xu, Nam Il Park, Hyun Ho Kim, Jae Eul Choi, Sang Un Park   +6 more
doaj   +1 more source

Evaluation of ginsenoside bioconversion of lactic acid bacteria isolated from kimchi

Journal of Ginseng Research, 2017
Background: Panax ginseng is a physiologically active plant widely used in traditional medicine that is characterized by the presence of ginsenosides. Rb1, a major ginsenoside, is used as the starting material for producing ginsenoside derivatives with ...
Boyeon Park, Hyelyeon Hwang, Jina Lee, Sung-Oh Sohn, Se Hee Lee, Min Young Jung, Hyeong In Lim, Hae Woong Park, Jong-Hee Lee   +8 more
doaj   +1 more source

Advances in the Neurotoxic Mechanisms of Acrylamide and Multitarget Intervention Strategies of Natural Products

Food Frontiers, Volume 7, Issue 4, July 2026.
This review summarizes recent advances in acrylamide neurotoxicity mechanisms and highlights the multitarget neuroprotective effects of diverse natural products while also addressing current challenges and future translational research directions.
Wen Du, Yifan Zhao, Li Dong, Chen Ma, Xiaosong Hu, Daotong Li, Fang Chen, Yinghua Luo   +7 more
wiley   +1 more source

Comparative analysis of the gut microbiota in people with different levels of ginsenoside Rb1 degradation to compound K.

PLoS ONE, 2013
Panax ginseng (family Araliaceae) which contains ginsenoside Rb1 as a main constituent is traditionally used as a remedy for cancer, inflammation, stress, and ageing.
Kyung-Ah Kim, Il-Hoon Jung, Se-Hoon Park, Young-Tae Ahn, Chul-Sung Huh, Dong-Hyun Kim   +5 more
doaj   +1 more source

Production of Gypenoside XVII from Ginsenoside Rb1 by Enzymatic Transformation and Their Anti-Inflammatory Activity In Vitro and In Vivo

Molecules, 2023
The enzymatic transformation of the sugar moiety of the gypenosides provides a new way to obtain more pharmacologically active components. A gene encoding a family 1 glycosyl hydrolase from Bifidobacterium dentium was cloned and expressed in Escherichia ...
Kailu Zhou, Yangyang Zhang, Yikai Zhou, Minghao Xu, Shanshan Yu   +4 more
doaj   +1 more source