Results 31 to 40 of about 5,968 (172)

Preventive treatment with ginsenoside Rb1 ameliorates monocrotaline-induced pulmonary arterial hypertension in rats and involves store-operated calcium entry inhibition

Pharmaceutical Biology, 2020
Context Ginsenoside Rb1, the main active ingredient of ginseng, exhibits ex vivo depression of store-operated calcium entry (SOCE) and related vasoconstriction in pulmonary arteries derived from pulmonary hypertension (PH) rats.
Rui-Xing Wang, Rui-Lan He, Hai-Xia Jiao, Run-Tian Zhang, Jing-Yi Guo, Xiao-Ru Liu, Long-Xin Gui, Mo-Jun Lin, Zhi-Juan Wu   +8 more
doaj   +1 more source

Translational potential of ginsenoside Rb1 in managing progression of osteoarthritis

Journal of Orthopaedic Translation, 2016
Osteoarthritis (OA) is the most common degenerative joint disorder. Inflammatory cytokine plays an important role in OA progression. Previous studies have demonstrated that ginsenoside Rb1 would prevent inflammation and apoptosis in chondrocytes. However, we have not found any animal study reporting that Rb1 attenuates the severity of OA.In this study,
Chen Yuanfeng, LinSien, Sun Yuxin, Pan Xiaohua, Xiao Liubin, Zou Liyi, Ho Ki Wai, Li Gang   +7 more
openaire   +4 more sources

Monoclonal Antibodies against Small Molecule Natural Products and Their Applications, Eastern Blotting and Knockout Extract

Pharmaceuticals, 2011
To determine the hapten number in hapten-carrier protein conjugate matrix-assisted laser desorption/ionization (MALDI) tof mass spectrometry was applied.
Yukihiro Shoyama
doaj   +1 more source

Analysis of Ginsenosides Rb1 and Rg1 Digestion Products in vitro Based on UHPLC-TSQ MS

Zhipu Xuebao
A method of ultra-high-performance liquid chromatography-triple quadrupole mass spectrometry (UHPLC-TSQ MS) was used to study the products of protopanaxadiol ginsenoside Rb1 and protopanaxatriol ginsenoside Rg1 in simulated digestion solution in vitro ...
Hua-zhou NIU, Yu-xin GUO, Ting ZHOU, Hui LI, Wei WU   +4 more
doaj   +1 more source

Effects of ginsenoside Rb1 on second-degree burn wound healing and FGF-2/PDGF-BB/PDGFR-β pathway modulation

Chinese Medicine, 2021
Background Panax notoginseng (Burk.) F. H. Chen (P. notoginseng) is a traditional Chinese medicine that has been used therapeutically for cardiovascular diseases, inflammatory diseases and traumatic injuries as well as for external and internal bleeding ...
Li Zhang, Qin Hu, Haonan Jin, Yongzhao Yang, Yan Yang, Renhua Yang, Zhiqiang Shen, Peng Chen   +7 more
doaj   +1 more source

Ginsenoside Rb1 ameliorates neutrophil extracellular traps-induced vascular endothelial damage by suppressing apoptosis

Bangladesh Journal of Pharmacology
The study aims to investigate the effect of ginsenoside Rb1 on improving neutrophil extracellular traps-induced vascular endothelial damage. The CCK8 assay was used to evaluate the impact of ginsenoside Rb1 on cell activity.
Biao Zhang, Junkai Zhao, Jiamin Yin, Jiaping Chen, Lingqi Xu   +4 more
doaj   +1 more source

A Decoy‐Receptor‐Armed Biomimetic Nanotherapeutic With Inherent Tropism for Conserved Pathogenic Macrophages for Treating Osteoarthritis and Intervertebral Disc Degeneration

Advanced Science, EarlyView.
A biomimetic doppelgänger nanosystem neutralizes extracellular inflammatory cytokines and silences intracellular pyroptosis, reprogramming pathogenic macrophages to attenuate both joint and spine degeneration. ABSTRACT Osteoarthritis (OA) and intervertebral disc degeneration (IVDD) are debilitating musculoskeletal disorders driven by shared ...
Fudong Li, Bin Zhang, Zhiqiu Zhang, Bing Zheng, Linhui Han, Chen Yan, Jialin Li, Kaiqiang Sun, Tianyi Zhao, Jiangang Shi   +9 more
wiley   +1 more source

Artificial Intelligence‐Driven Network Pharmacology: A Methodological Paradigm Shift Bridging Traditional Wisdom and Modern Science

Advanced Intelligent Discovery, EarlyView.
Artificial intelligence is redefining network pharmacology (NP). By integrating knowledge graph engineering, geometric deep learning, multiomics anchoring, and generative reasoning, AI‐driven NP (AI‐NP) transforms static target mapping into dynamic, predictive modeling.
Cong Wang, Sile Hu, Rigahai Ji, Riguna A, Siqige Hao, Ma Zhuo, Yi‐Hung Chen, Bisihalatu Hu, Ulana Bai, Xigui Hada   +9 more
wiley   +1 more source

Ginsenoside Rb1 is transformed into Rd and Rh2 by Microbacterium trichothecenolyticum

Journal of Microbiology and Biotechnology, 2013
Ginsenosides are the most important ingredient of ginseng and are known to possess many pharmacological and biological effects. Rb1, a major protopanaxadiol ginsenoside, is the most abundant ginsenoside in Panax ginseng C.A Meyer and can be hydrolyzed into more pharmaceutically potent minor ginsenosides.
Hansoo, Kim, Jeong-Hoon, Kim, Phil Young, Lee, Kwang-Hee, Bae, Sayeon, Cho, Byoung Chul, Park, Heungsop, Shin, Sung Goo, Park   +7 more
openaire   +2 more sources

Ginsenoside Rb1 affects mitochondrial Ca2+ transport and inhibits fat deposition and fibrosis by regulating the wnt signaling pathway to treat rotator cuff tears via docking with SFRP1

Molecular Medicine
Background Rotator cuff tears (RCTs) are among the most common musculoskeletal disorders that affect quality of life. This study aimed to investigate the efficacy of ginsenoside Rb1 in RCTs and the mechanisms involved.
Yuesong Yin, Hai Hu, Yian Yang, Song Wu
doaj   +1 more source