Results 51 to 60 of about 5,667 (130)

Chromosome‐Level Genome Assembly of the Allotetraploid Gynostemma pentaphyllum Provides Novel Insights Into the Biosynthesis of Ginsenoside and Gypenoside LVI

Plant Biotechnology Journal, Volume 24, Issue 6, Page 4204-4220, June 2026.
ABSTRACT Gynostemma pentaphyllum, a herb used in tea and traditional Chinese medicine, shows geographic variation in its production of valuable dammarane‐type ginsenosides and gypenoside LVI between populations from Suining (SN) and Nanning (NN). To elucidate the mechanisms underlying this differential metabolite accumulation, a chromosome‐level genome
Peina Zhou, Si‐Jie Liu, Lijin Huang, Yingping Wang, Xinyu Jiang, Wang Dong, Jianfeng Gong, Long Wang, Yuyin Zhao, Huiying Wang, Ping Li, Jia‐Yu Xue, Xu Lu   +12 more
wiley   +1 more source

Targeted metabolomics reveals the role of ginsenoside Rb1 in modulating inflammation and cellular senescence in sepsis-induced acute lung injury

Food Science and Human Wellness
Sepsis-induced acute lung injury (ALI) is a major clinical challenge, with limited treatment options and high mortality. Ginsenoside Rb1, a bioactive compound derived from ginseng, has shown promising anti-inflammatory and antioxidative effects.
Fushuang Zheng, Wei Wang, Linlin Gao, Zhiling Fu   +3 more
doaj   +1 more source

Nanotherapies for Atherosclerosis: Targeting, Catalysis, and Energy Transduction

Advanced Healthcare Materials, Volume 15, Issue 20, 27 May 2026.
Atherosclerosis management is hindered by poor drug targeting and plaque heterogeneity. Nanotechnology overcomes these barriers via three core strategies: (1) target‐engineered nanocarriers that achieve lesion‐specific precision via ligand modification, biomimetic camouflage, stimuli‐responsive release, and self‐propelling nanomotors; (2) catalytic ...
Yuqi Yang, Jingguo Qu, Tonghuan Xiao, Xinyang Han, Michael Tin‐Cheung Ying   +4 more
wiley   +1 more source

Emerging Roles of Adenosine Metabolism in Astrocytes During Brain Injury

CNS Neuroscience &Therapeutics, Volume 32, Issue 5, May 2026.
Adenosine, as a key metabolic and neurotransmitter in the brain, has become an important therapeutic target for improving the efficacy of immunotherapy for stroke. However, gaps in knowledge about its metabolic pathways have become a key factor limiting its clinical translation.
Shu Zhu, Shanshan Zhong, Xiaoru Lin, Chuansheng Zhao, Yugang Li   +4 more
wiley   +1 more source

Emerging Role of Panax ginseng in the Management of Cancer: Phytochemistry, SAR, Therapeutic Potential, and Clinical Aspects

Food Frontiers, Volume 7, Issue 3, May 2026.
This review aims to provide a comprehensive understanding of the therapeutic potential of bioactive anticancer phytoconstituents in Panax ginseng, including their clinical aspects and SAR, thereby fostering the development of newer anticancer compounds for cancer management.
Akrit Verma, Sanjeev Kumar Sahu, Anil Kumar Sah   +2 more
wiley   +1 more source

Protective Effect of Ginsenoside Rb1 Against Lung Injury Induced by Intestinal Ischemia-Reperfusion in Rats

Molecules, 2013
Intestinal ischemia-reperfusion (I/R) is a critical event in the pathogenesis of multiple organ dysfunction syndromes (MODS). The lungs are some of the most vulnerable organs that are impacted by intestinal I/R.
Guangtian Yang, Shusheng Li, Lifen Qiao, Jin Wang   +3 more
doaj   +1 more source

Chemical Comparison of Two Drying Methods of Mountain Cultivated Ginseng by UPLC-QTOF-MS/MS and Multivariate Statistical Analysis

Molecules, 2017
In traditional Chinese medicine practice, drying method is an essential factor to influence the components of Chinese medicinal herbs. In this study, an ultra-performance liquid chromatography quadrupole time-of-flight tandem mass spectrometry (UPLC-QTOF-
Xin-fang Xu, Shu-ya Xu, Ying Zhang, Hui Zhang, Meng-nan Liu, Huan Liu, Yan Gao, Xue Xue, Hui Xiong, Rui-chao Lin, Xiang-ri Li   +10 more
doaj   +1 more source

Integrating mass spectrometry and systems biology for the modernization of natural medicines: From deciphering chemical complexity to holistic efficacy assessment

VIEW, Volume 7, Issue 2, April 2026.
This review explores how mass spectrometry is transforming research in natural medicines, with Traditional Chinese medicine (TCM) as a primary exemplar. It details the application of advanced mass spectrometry in chemical analysis, the development of comprehensive quality control methods, and systematic research on the targeted mechanisms of single ...
Yudian Xu, Linlin Cao, Chenhuan Ding, Chen Wang, Yi Lai, Dan Ru, He Li, Wei Xu   +7 more
wiley   +1 more source

Attenuation of TNF-α-Induced Inflammatory Injury in Endothelial Cells by Ginsenoside Rb1 via Inhibiting NF-κB, JNK and p38 Signaling Pathways

Frontiers in Pharmacology, 2017
It is currently believed that inflammation plays a central role in the pathophysiology of atherosclerosis. Oxidative stress and redox-sensitive transcription factors are implicated in the process.
Ping Zhou, Ping Zhou, Ping Zhou, Ping Zhou, Shan Lu, Shan Lu, Shan Lu, Shan Lu, Yun Luo, Yun Luo, Yun Luo, Yun Luo, Shan Wang, Shan Wang, Shan Wang, Shan Wang, Ke Yang, Ke Yang, Ke Yang, Ke Yang, Yadong Zhai, Yadong Zhai, Yadong Zhai, Yadong Zhai, Guibo Sun, Guibo Sun, Guibo Sun, Guibo Sun, Xiaobo Sun, Xiaobo Sun, Xiaobo Sun, Xiaobo Sun   +31 more
doaj   +1 more source

Targeting Autophagy in Ovarian Cancer: The Emerging Role of Ginsenosides

Cancer Medicine, Volume 15, Issue 3, March 2026.
ABSTRACT Background Ovarian cancer, the third most prevalent gynecological malignancy, is frequently diagnosed at an advanced stage owing to its asymptomatic early progression. Despite the application of conventional therapies, clinical management remains limited by adverse effects and the development of drug resistance.
Yuxin Guo, Cuilan Yun, Yuemei Zhang, Xu Yang, Huiqin Liu   +4 more
wiley   +1 more source