Results 61 to 70 of about 5,735 (170)
This review summarizes recent advances in acrylamide neurotoxicity mechanisms and highlights the multitarget neuroprotective effects of diverse natural products while also addressing current challenges and future translational research directions.
Wen Du +7 more
wiley +1 more source
The prevalence of fine particulate matter-induced harm to the human body is increasing daily. The aim of this study was to elucidate the mechanism by which particulate matter 2.5 (PM2.5) induces damage in human HaCaT keratinocytes and normal human dermal
Mei Jing Piao +9 more
doaj +1 more source
The schematic diagram illustrating the improvement mechanisms of six typical FMH substances and their main active ingredients in different sleep disorders. ABSTRACT Sleep integrates many brain and peripheral processes, profoundly influencing well‐being.
Wenjing Wen +9 more
wiley +1 more source
This study demonstrates that oleanolic acid (OA) may ameliorate type 2 diabetes mellitus (T2DM) by modulating hepatic lipid metabolism and autophagy in a manner concomitant with STAT3 phosphorylation. Specifically, OA downregulates fatty acid synthesis/uptake‐related proteins (SREBP‐1, ACC, CD36), upregulates fatty acid β‐oxidation‐related protein ...
Zirui Ji +7 more
wiley +1 more source
Sepsis-induced acute lung injury (ALI) is a major clinical challenge, with limited treatment options and high mortality. Ginsenoside Rb1, a bioactive compound derived from ginseng, has shown promising anti-inflammatory and antioxidative effects.
Fushuang Zheng +3 more
doaj +1 more source
Schematic illustration of the experimental design and the hepatoprotective effect of Phyllanthus emblica and Panax ginseng against acetaminophen (APAP)‐induced fibrosis in Wistar rats. APAP administration leads to NAPQI formation and accumulation, which causes GSH depletion and HSC activation. This ultimately becomes the primary cause of liver fibrosis.
Fiza Javed +8 more
wiley +1 more source
Urologic Bacteriome: The Hero or the Villain in Prostate Cancer Onset, Progression, and Treatment?
ABSTRACT Prostate cancer (PCa) is the second most frequently diagnosed cancer in men worldwide and the fifth leading cause of cancer‐related mortality, presenting urgent unmet clinical needs in diagnosis and treatment. The recognition of the microbiome as a key factor in human health has prompted numerous studies, revealing an exciting new approach to ...
Lara R. S. Fonseca +6 more
wiley +1 more source
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Contrasting actions of ginsenosides Rb1 and Rg1 on glucose tolerance in rats
Ginsenoside profile of Panax ginseng is changing with season and cultivated soil. Yet, dose-response relationship of main ginsenosides on metabolic measures has not been documented in vivo. Here, we examined glucose and insulin responses after an oral glucose challenge (0.5 g/kg body weight) at various doses (0.01, 0.1, 1, and 10 mg/kg of body weight ...
Rungchai Chaunchaiyakul +4 more
openaire +3 more sources
Intestinal ischemia-reperfusion (I/R) is a critical event in the pathogenesis of multiple organ dysfunction syndromes (MODS). The lungs are some of the most vulnerable organs that are impacted by intestinal I/R.
Guangtian Yang +3 more
doaj +1 more source

