Results 61 to 70 of about 107,123 (321)

Therapeutic vulnerability to PARP1,2 inhibition in RB1-mutant osteosarcoma [PDF]

, 2021
Loss-of-function mutations in the RB1 tumour suppressor are key drivers in cancer, including osteosarcoma. RB1 loss-of-function compromises genome-maintenance and hence could yield vulnerability to therapeutics targeting such processes.
Steele, CD, Scotlandi, K, Cristalli, C, Steele, Christopher C.D., Pillay, Nischalan, Manji, J, Pillay, N, Ahmed, R-M, Davies, LR, Roy, E, Manji, Jiten, Denman, M, Mittnacht, Sibylle, Alvarez-Mendoza, Carlos, Mittnacht, S, Ahmed, Ritika Mahmuda, Denman, Milly, Zoumpoulidou, Georgia, Strauss, SJ, Zoumpoulidou, G, Scotlandi, Katia, Roy, Errin, Mancusi, C, Tarabichi, M, Alvarez-Mendoza, C, Mancusi, Caterina, Davies, Lauren L.R., Cristalli, Camilla, Strauss, Sandra J, Tarabichi, Maxime   +29 more
core   +1 more source

Ginsenoside CK, rather than Rb1, possesses potential chemopreventive activities in human gastric cancer via regulating PI3K/AKT/NF-κB signal pathway

Frontiers in Pharmacology, 2022
Ginsenoside Rb1, a main component of ginseng, is often transformed into ginsenoside CK by intestinal flora to exert various pharmacological activity. However, it remains unclear whether ginsenoside CK is responsible for the anti-gastric cancer effect of ...
Y. Wan, Dong Liu, J. Xia, Jin-feng Xu, Li Zhang, Yu Yang, Jiao-jiao Wu, Hui Ao   +7 more
semanticscholar   +1 more source

Effects of berberine (BBR) to inhibit the degradation of RB1 mRNA with poly(A) (RB1-pro-RB1) or without poly(A) (RB1-pro-RB1-Δpoly A-).

, 2014
(A) Cartoon of the plasmid models used in this study. Polyadenylation signals were showed in red. (B) Expressions of GFP in cells with transfection of RB1-promoter-RB1-GFP with and without poly(A) plasmids detected using Western blot.
Li-Jun Du (288666), Yu-Shuang Chai (288661), Zhi-Yi Yuan (288662), Feng Du (288665), Fan Lei (288658), Dong-Ming Xing (288664), Jun Hu (5721), Jing-Fei Jiang (288656), Yu-Gang Wang (288657), Xi Lu (288663)   +9 more
core   +1 more source

RB1‑promoter methylation in glioblastoma: A rare event in glioblastoma [PDF]

, 2023
The retinoblastoma gene (RB1) is a tumor suppressor gene that serves a key role in the development of numerous tumor diseases that can be downregulated by DNA methylation within its promoter region.
Sippl, Christoph, Henia, Mohamed, Urbschat, Steffi, Breitfelder, Gerrit, Oertel, Joachim, Schulz-Schaeffer, Walter, Ketter, Ralf   +6 more
core   +1 more source

Promoter Hypermethylation of the RB1 Gene in Glioblastomas [PDF]

Laboratory Investigation, 2001
Loss of expression of the retinoblastoma gene (RB1) has been shown to occur in up to 25% of glioblastomas (WHO Grade IV). To elucidate the underlying mechanism, we assessed RB1 promoter hypermethylation using methylation-specific polymerase chain reaction and RB1 expression by immunohistochemistry in 35 primary (de novo) glioblastomas and in 21 ...
M, Nakamura, Y, Yonekawa, P, Kleihues, H, Ohgaki   +3 more
openaire   +2 more sources

Ginsenoside Rb1 Induces Beta 3 Adrenergic Receptor–Dependent Lipolysis and Thermogenesis in 3T3-L1 Adipocytes and db/db Mice

Frontiers in Pharmacology, 2019
Obesity is constantly rising into a major health threat worldwide. Activation of brown-like transdifferentiation of white adipocytes (browning) has been proposed as a promising molecular target for obesity treatment.
Seona Lim, Seona Lim, Jinbong Park, Jinbong Park, Jae-Young Um, Jae-Young Um, Jae-Young Um   +6 more
doaj   +1 more source

Melanocyte homeostasis in vivo tolerates Rb1 loss in a developmentally independent fashion

, 2010
There has been uncertainty regarding the precise role that the pocket protein Rb1 plays in murine melanocyte\ud homeostasis. It has been reported that the TAT-Cre mediated loss of exon 19 from a floxed Rb1 allele causes\ud melanocyte apoptosis in vivo ...
Kay, GF, Walker, Graeme J., Kay, Graham F., Wayne A. Schroder, Mould, AW, Schroder, WA, Ian D. Tonks, Arne W. Mould, Hayward, NK, Tonks, ID, Graeme J. Walker, Tonks, Ian D., Bosenberg, Marcus, Mould, Arne W., Bosenberg, M, Schroder, Wayne A., Hacker, Elke, Hacker, E, Elke Hacker, Hayward, Nicholas K., Walker, GJ, Marcus Bosenberg, Nicholas K. Hayward, Graham F. Kay   +23 more
core   +1 more source

Progression of Low-Grade Neuroendocrine Tumors (NET) to High-Grade Neoplasms Harboring the NEC-Like Co-alteration of RB1 and TP53

Endocrine pathology
High-grade or grade 3 epithelial neuroendocrine neoplasms (G3 NEN) are now divided into grade 3 well-differentiated neuroendocrine tumor (G3 NET) and neuroendocrine carcinoma (NEC), both defined by Ki-67 > 20% and/or > 20 mitoses per 2 mm2.
Nancy M Joseph, Sarah E. Umetsu, Grace E Kim, Merryl Terry, Arie Perry, E. Bergsland, Sanjay Kakar   +6 more
semanticscholar   +1 more source

RB1 gene mutations in retinoblastoma [PDF]

Human Mutation, 1999
Mutations in both alleles of the RB1 gene are causal for the development of retinoblastoma, a childhood tumor of the eye. The spectrum of somatic and germline mutations in this gene is dominated by small mutations. Data on small mutations are listed in a locus specific database available at http://www.d-lohmann.de/Rb/mutations.html.
openaire   +2 more sources

Genetic detection of bladder cancer by microsatellite analysis of p16, RB1 and p53 tumor suppressor genes

, 2001
Purpose: We investigated the incidence of genetic alterations in urine specimens from patients with bladder cancer. Materials and Methods: A total of 28 cytological urine specimens were assessed for microsatellite alternations, and 15 microsatellite ...
Kazanis, I., Sourvinos, G., Cranidis, A., Delakas, D., Spandidos, D.A.   +4 more
core   +1 more source