Results 81 to 90 of about 107,123 (321)

Mechanism of abnormal specification of spermatogonial stem cells after Rb1 knockout in mitotic-arrested prospermatogonia

陆军军医大学学报
Objective‍　‍To investigate the underlying mechanism of abnormal specification of spermatogonial stem cells （SSCs） in male mice following Rb1 conditional knockout in mitotic-arrested prospermatogonia.
CHEN Xinling, CHEN Xinling, LONG Yixuan, DU Guihua, DU Guihua   +4 more
doaj   +1 more source

Ginsenoside Rb1, A Major Saponin from Panax ginseng, Exerts Protective Effects Against Acetaminophen-Induced Hepatotoxicity in Mice

, 2019
Acute liver injury (ALI) induced by acetaminophen (APAP) is the main cause of drug-induced liver injury. Previous reports indicated liver failure could be alleviated by saponins (ginsenosides) from Panax ginseng against APAP-induced inflammatory ...
Jiang, Shuang, Wang, Zi, Ren, Shen, Chen, Chen, Yan, Xiao-Tong, Leng, Jing, Liu, Zhi, Xu, Xing-Yue, Li, Wei, Wang, Ying-Ping   +9 more
core   +1 more source

Concurrent RB1 and TP53 alterations define a subset of EGFR-mutant lung cancers at risk for histologic transformation and inferior clinical outcomes

Journal of Thoracic Oncology, 2019
Introduction: EGFR-mutant lung cancers are clinically and genomically heterogeneous with concurrent RB1/TP53 alterations identifying a subset at increased risk for small cell transformation.
M. Offin, J. Chan, M. Tenet, H. Rizvi, R. Shen, Gregory Riely, N. Rekhtman, Y. Daneshbod, Á. Quintanal-Villalonga, A. Penson, M. Hellmann, M. Arcila, M. Ladanyi, D. Pe’er, M. Kris, C. Rudin, H. Yu   +16 more
semanticscholar   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Tourism as a driver of economic and social development in underdeveloped regions

Regional Science Policy &Practice, EarlyView., 2023
Abstract Cross‐border cooperations have been usually approached by developing trade agreements between international regions to upgrade their socioeconomic conditions and promote international tourism flows in territories. However, little attention has been paid to the role that tourist companies play in underprivileged territories highly dependent on ...
Rafael Robina‐Ramírez, Jesús Torrecilla‐Pinero, Ana Leal‐Solís, Juan Antonio Pavón‐Pérez   +3 more
wiley   +1 more source

Tailoring Phonon‐Driven Responses in α‐MoO3 through Isotopic Enrichment

Advanced Materials, EarlyView.
ABSTRACT The implementation of polaritonic materials into nanoscale devices requires selective tuning of parameters to realize desired spectral or thermal responses. One robust material, α‐MoO3, an orthorhombic crystal boasting three distinct phonon dispersions, provides three polaritonic dispersions of hyperbolic phonon polaritons (HPhPs) across the ...
Thiago S. Arnaud, Ryan W. Spangler, Johnathan D. Georgaras, Jonah B. Haber, Daniel Hirt, Maximilian Obst, Gonzalo Álvarez‐Pérez, Mackey Long III, Felix G. Kaps, Jakob Wetzel, Courtney Ragle, John E. Buchner, Youngji Kim, Aditha S. Senarath, Richarda Niemann, Mingze He, Giulia Carini, Unai Arregui‐Leon, Akash C. Behera, Ramachandra Bangari, Nihar Sahoo, Niels C. Brumby, J. Michael Klopf, Martin Wolf, Lukas M. Eng, Susanne C. Kehr, Thomas G. Folland, Alexander Paarmann, Patrick E. Hopkins, Felipe Jornada, Jon‐Paul Maria, Joshua D. Caldwell   +31 more
wiley   +1 more source

CDK4/6 Inhibition Induces CD8+ T Cell Antitumor Immunity via MIF‐Induced Functional Orchestration of Tumor‐Associated Macrophages

Advanced Science, EarlyView.
CDK4/6 inhibition promotes CD8+ T cell expansion through tumor‐macrophage crosstalk by activating HIF‐1α and enhancing MIF‐CD44/CD74 signaling. This reprograms TAMs to boost MHC‐I antigen presentation, and CDK4/6 inhibitor‐trained M1 TAM supernatant therapy synergizes with low‐dose PD‐1 blockade to restore antitumor immunity.
Lin He, Yuzhong Peng, Lat‐lun Leong, Jingbo Zhou, Dongyang Tang, Weilu Wang, Xiaoran Wu, Josh haipeng Lei, Yongqin Ye, Yangyang Feng, Yunfeng Qiao, Xiangpeng Chu, Di Mu, Qi Zhao, Tzuming Liu, Yan Chen, Paul Kwonghang Tam, Chu‐Xia Deng   +17 more
wiley   +1 more source

Retinoblastoma mutation predicts poor outcomes in advanced non small cell lung cancer

Cancer Medicine, 2019
The retinoblastoma gene (RB1) encodes the retinoblastoma (RB) pocket protein that plays an important role in cell cycle progression. Here we determine the frequency and prognostic significance of RB1 mutation in non small cell lung cancer (NSCLC ...
Priyanka Bhateja, Michelle Chiu, Gary Wildey, Mary Beth Lipka, Pingfu Fu, Michael Chiu Lee Yang, Fatemeh Ardeshir‐Larijani, Neelesh Sharma, Afshin Dowlati   +8 more
doaj   +1 more source

Proteomic analysis reveals that the protective effects of ginsenoside Rb1 are associated with the actin cytoskeleton in β-amyloid-treated neuronal cells

Journal of Ginseng Research, 2016
Background: The ginsenoside Rb1 (Rb1) is the most abundant compound in the root of Panax ginseng. Recent studies have shown that Rb1 has a neuroprotective effect. However, the mechanisms underlying this effect are still unknown.
Ji Yeon Hwang, Ji Seon Shim, Min-Young Song, Sung-Vin Yim, Seung Eun Lee, Kang-Sik Park   +5 more
doaj   +1 more source

Interaction of Rb1 with viral hemagglutinin.

, 2017
(A) Serially diluted A/Nanchang/8002/2009 (H1N1) virus was pre-incubated with different concentrations of Rb1 or HBSS for 1 hour and used for hemagglutination inhibition assay. A significant reduction in HA titer of Rb1 treated virus was observed in dose
Alberto J. Leon (132911), Amber Farooqui (315564), David J. Kelvin (132963), Wei Dong (6479)   +3 more
core   +1 more source