Results 91 to 100 of about 107,123 (321)
RB1 loss overrides PARP inhibitor sensitivity driven by RNASEH2B loss in prostate cancer
Science Advances, 2022 Current targeted cancer therapies are largely guided by mutations of a single gene, which overlooks concurrent genomic alterations. Here, we show that RNASEH2B , RB1 , and BRCA2 , three closely located genes on chromosome 13q, are frequently ...
Chenkui Miao +12 more
semanticscholar +1 more source
Advanced Science, EarlyView.In colorectal cancer, high expression of the DNA repair protein EEPD1 correlates with immune exclusion and poor prognosis. This study demonstrates that EEPD1 depletion induces genomic instability, leading to cytosolic DNA accumulation and subsequent activation of the cGAS‐STING‐type I interferon pathway. This cascade remodels the tumor microenvironment
Liyun Huo +8 more
wiley +1 more source
Nutrition & Metabolism, 2020 Background Obesity, characterized by the excessive accumulation of triglycerides in adipocytes and their decreased excretion from adipocytes, is closely related to various health problems.
Rong Guo +7 more
doaj +1 more source
A Mouse Model for Imprinting of the Human Retinoblastoma Gene. [PDF]
PLoS ONE, 2015 The human RB1 gene is imprinted due to integration of the PPP1R26P1 pseudogene into intron 2. PPP1R26P1 harbors the gametic differentially methylated region of the RB1 gene, CpG85, which is methylated in the female germ line.
Vasiliki Tasiou +2 more
doaj +1 more source
Ginsenoside Rb1 Ameliorates Diabetic Arterial Stiffening via AMPK Pathway
Frontiers in Pharmacology, 2021 Background and Purpose: Macrovascular complication of diabetes mellitus, characterized by increased aortic stiffness, is a major cause leading to many adverse clinical outcomes.
Xinyu Zhang +9 more
doaj +1 more source
Pharmacokinetic Study of Ginsenosides Rb1 and Rg1 in Rat by ELISA Using Anti-ginsenosides Rb1 and Rg1 Monoclonal Antibodies [PDF]
, 2020 : Enzyme-linked immunosorbent assay (ELISA) systems using anti-ginsenoside Rb1 (G-Rb1) and Rg1 (G-Rg1) monoclonal antibodies (MAbs) were established for pharmacokinetic investigations of G-Rb1 and G-Rg1 in rat serum.
Yukihiro Shoyama +2 more
core
The Rapidly Expanding Group of RB1-Deleted Soft Tissue Tumors: An Updated Review
Diagnostics, 2021 The classification of soft tissue tumors has evolved considerably in the last decade, largely due to advances in understanding the pathogenetic basis of many of these, sometimes rare, tumors.
S. Libbrecht, J. van Dorpe, D. Creytens
semanticscholar +1 more source
Advanced Science, EarlyView.Multi‐omic profiling of T1 high‐grade bladder cancer identifies a high‐risk subtype (T1HG1) driven by NQO1, which couples anoikis resistance with immune evasion. NQO1 orchestrates macrophage–T cell crosstalk suppression via CXCL9 modulation. Pharmacological NQO1 inhibition with skullcapflavone II enhances cisplatin efficacy, representing a promising ...
Bin Guo +20 more
wiley +1 more source
Brain Transport Profiles of Ginsenoside Rb1 by Glucose Transporter 1: In Vitro and in Vivo
Frontiers in Pharmacology, 2018 Ginsenoside Rb1 (Rb1) has been demonstrated its protection for central nervous system and is apparently highly distributed to the brain. The objective of this study was to characterize Rb1 transport at the blood–brain barrier (BBB) using primary cultured
Yu-Zhu Wang +7 more
doaj +1 more source
Journal of Integrative Neuroscience, 2021 The purpose of our research was to evaluate whether ginsenoside Rb1 has neuroprotective effects against lipopolysaccharide (LPS)-induced brain injury. ICR mice were intraperitoneally (i.p.) injected with 20 or 40 mg/kg Rb1 or saline for 7 consecutive ...
Huiming Zhang +5 more
doaj +1 more source