Results 101 to 110 of about 107,123 (321)

RB1 and TP53 co-mutations correlate strongly with genomic biomarkers of response to immunity checkpoint inhibitors in urothelial bladder cancer

BMC Cancer, 2021
Muscle invasive urothelial bladder carcinoma (MIBC) present RB1 and TP53 somatic alterations in a variable percentage of tumors throughout all molecular subtypes.
R. G. Manzano, A. Catalán-Latorre, A. Brugarolas   +2 more
semanticscholar   +1 more source

Lactoferrin Deficiency During Lactation Causes Adult Obesity‐Related Metabolic Disease Through Persistent Adipose Dysfunction Driven by Impaired Adipocyte Development

Advanced Science, EarlyView.
Lactational lactoferrin deficiency exerts lasting effects on epididymal adipose tissue development from lactation into adulthood: it impairs adipocyte hyperplasia and induces pathological hypertrophy, resulting in lower body weight yet exacerbated metabolic dysfunction under a high‐fat diet in adulthood.
Qin An, Yunxia Zou, Wenli Wang, Zhimei Cheng, Zhuoxing Zhang, Ruwei Liu, Xiong Wang, Kunlun Huang, Fangrong Ding, Yunping Dai, Qingyong Meng, Yali Zhang   +11 more
wiley   +1 more source

RB1 architecture and study design.

, 2013
A. Schematic of RB1 domain structure. RB1 NH2-terminal domain (RB-N, light blue), RB1 pocket-domain (RB-P, raspberry), the position of the twin cyclin folds which form the core of each domain is indicated, RB1 C-terminal region (RB-C, yellow). B.
Sibylle Mittnacht (180896), Edward P. Morris (389652), Ekaterina P. Lamber (389651), Fabienne Beuron (67882), Dmitri I. Svergun (25365)   +4 more
core   +1 more source

Ginsenoside Rb1 as a neuroprotective agent: A review

Brain Research Bulletin, 2016
Ginsenosides represent the major bioactive components of ginseng. These triterpenoid saponins have been shown to exert numerous beneficial effects on the human body. Recent evidences suggest that ginsenosides may be useful for the management and treatment of several diseases of the central nervous system (CNS).
Touqeer, Ahmed, Syed Hammad, Raza, Afifa, Maryam, William N, Setzer, Nady, Braidy, Seyed Fazel, Nabavi, Marcos Roberto, de Oliveira, Seyed Mohammad, Nabavi   +7 more
openaire   +2 more sources

MiR‐940 Suppresses Ferroptosis by Controlling Expression of Key Regulatory Genes

Advanced Science, EarlyView.
A CRISPR‐based screening identified miR‐940 as a critical suppressor of ferroptosis in cancer. By coordinating the downregulation of pro‐ferroptotic genes with the upregulation of GPX4, miR‐940 establishes a regulatory network that protects against ferroptosis and correlates with poor clinical outcomes in distinct cancer entities.
Andrea Kolak, Juliane Tschuck, Stefanie A. I. Weiß, Daniel Kaemena, Karolin Klimm, Ana Galhoz, Larissa Ringelstetter, Myles Fennell, Juliane Merl‐Pham, Anna Artati, Stefanie Strasser, Ralph Garippa, Michael Witting, Hans Zischka, Joel A. Schick, Stefanie M. Hauck, Michael P. Menden, Michelle Vincendeau, Brent R. Stockwell, Kamyar Hadian   +19 more
wiley   +1 more source

Ginsenoside Rb1 promotes PC12 cell cycle kinetics through an adenylate cyclase-dependent protein kinase A pathway. [PDF]

, 2012
[[abstract]]Ginsenoside Rb1 (G-Rb1), a constituent of ginseng, bears various beneficial effects on neuroendocrine cells. Previous studies have indicated that G-Rb1 can enhance glutamate release in undifferentiated and differentiated PC12 cells via the ...
Shin-Da Lee;Ming-Jae Lo
core  

BRCAness, SLFN11, and RB1 loss predict response to topoisomerase I inhibitors in triple-negative breast cancers

Science Translational Medicine, 2020
Triple-negative breast cancer xenografts with BRCAness, high expression of SLFN11, and RB1 loss are highly sensitive to topoisomerase I inhibitors. Starting at the TOP for cancer treatment Topoisomerase (TOP) inhibitors are chemotherapeutic drugs that ...
F. Coussy, R. El-Botty, S. Chateau-Joubert, A. Dahmani, Elodie Montaudon, Sophie Leboucher, Ludivine Morisset, Pierre Painsec, L. Sourd, L. Huguet, F. Némati, J. Servely, T. Larcher, S. Vacher, A. Briaux, C. Reyes, P. La Rosa, Georges Lucotte, T. Popova, P. Foidart, N. Sounni, A. Noel, D. Decaudin, L. Fuhrmann, A. Salomon, F. Reyal, C. Mueller, Petra J ter Brugge, J. Jonkers, M. Poupon, M. Stern, I. Bièche, Y. Pommier, E. Marangoni   +33 more
semanticscholar   +1 more source

A Foundation Model Based CT Biomarker for Non‐Invasive Prediction of Response to Neoadjuvant Immunochemotherapy in Non‐Small Cell Lung Cancer

Advanced Science, EarlyView.
This study introduces a foundation model‐based biomarker for risk stratification of pathological response in non‐small cell lung cancer. A Vision Mamba super‐resolution model standardizes heterogeneous CT images. A multi‐task Swin Transformer then fine‐tunes a pre‐trained lung foundation model to jointly optimize tumor segmentation and response ...
Yanglan Xu, Shuchang Zhou, Qin Peng, Xiao Bao, Xiaodan Ye, Ahmet Görkem Er, Tong Tong, Mirabela Rusu, Yajia Gu, Mailin Chen, Jing Gong   +10 more
wiley   +1 more source

Ginsenoside Rb1 and Rb2 upregulate Akt/mTOR signaling–mediated muscular hypertrophy and myoblast differentiation

Journal of Ginseng Research, 2020
Background: As a process of aging, skeletal muscle mass and function gradually decrease. It is reported that ginsenoside Rb1 and Rb2 play a role as AMP-activated protein kinase activator, resulting in regulating glucose homeostasis, and Rb1 reduces ...
Ga-Yeon Go, Ayoung Jo, Dong-Wan Seo, Woo-Young Kim, Yong Kee Kim, Eui-Young So, Qian Chen, Jong-Sun Kang, Gyu-Un Bae, Sang-Jin Lee   +9 more
doaj   +1 more source

Rb1 mRNA expression in developing mouse teeth [PDF]

Gene Expression Patterns, 2012
Rb1 is a tumor suppressor gene that regulates cell cycle progression through interactions with E2F transcription factors. In recent years, new roles for Rb1 in regulating cellular differentiation have also emerged. For example, it has been shown that Rb1 regulates osteoblast differentiation in a cell cycle independent manner, by binding to the ...
Viktoria, Andreeva, Justin, Cardarelli, Pamela C, Yelick   +2 more
openaire   +2 more sources