Results 121 to 130 of about 107,123 (321)
Food Safety and Health, EarlyView.This review summarizes the chemical constituents and functional characteristics of American ginseng, aiming to provide references for its development and application. ABSTRACT American ginseng, a perennial herbaceous plant, is recognized for its significant medicinal properties and has attracted considerable attention due to its diverse phytochemical ...
Wei Geng +5 more
wiley +1 more source
RB1CC1 activates RB1 pathway and inhibits proliferation and cologenic survival in human cancer.
PLoS ONE, 2010 RB1-inducible coiled-coil 1 (RB1CC1, also known as FIP200) plays a role in the enhancement of the RB1 pathway through the direct binding to a GC-rich region 201bp upstream (from the initiation ATG) of the RB1 promoter.
Tokuhiro Chano +16 more
doaj +1 more source
Berberine (BBR) up-regulated the RB1 mRNA, but couldn’t influence the activity of RB1 promoter.
, 2014 (A) RB1 mRNA level in primary neurons as measured using real-time PCR. BBR (0.5 µg/ml) was added in the culture 1 h before OGD treatment and throughout the reperfusion time. Data represent the mean ± S.D.
Li-Jun Du (288666) +9 more
core +1 more source
Research progress on the role of inflammatory mediators in the pathogenesis of epilepsy
Ibrain, Volume 11, Issue 1, Page 44-58, Spring 2025.In the central nervous system, activated immune cells lead to the overproduction of inflammatory mediators through the corresponding signal pathway. Under the stimulation of inflammatory factors, neuroinflammation ultimately occurs. Overexpression of inflammatory mediators and activated immunocytes plays an important role in the emergence and ...
Yue Yu, Fei‐Ji Sun
wiley +1 more source
Rb1 does not inhibit Sirt1 depletion-induced senescence.
, 2014 (A) The Sirt1 protein level was evaluated by a Western blot analysis 72 hours after siRNA transfection with or without Rb1 supplementation. (B) The PAI-1 protein expression was examined 72 hours after siRNA transfection.
Lin Wu (153444) +12 more
core +1 more source
EVALUATING THE METHYLATION STATUS OF RB1 GENE PATIENTS WITH RETINOBLASTOMA
, 2022 OBJECTIVES: The most frequently diagnosed malignant ocular tumor of infancy and childhood is Retinoblastoma. Due to the mutation on the q14 on chromosome 13 causes the retinoblastoma.
Yazıcı, Hülya +8 more
core +1 more source
International Journal of Cancer, EarlyView.Acute myeloid leukemia adult cases often appear cytogenetically normal when analyzed with conventional karyotyping. However, acquired structural variants may escape routine detection. Here, optical genome mapping detected diverse genomic alterations in nearly half of the analyzed cytogenetically normal cases.
Tuuni Turtinen +7 more
wiley +1 more source
iNew Medicine, EarlyView.ABSTRACT Ovarian cancer (OC) continues to be the deadliest gynecological malignancy and a significant cause of cancer‐related mortality among women worldwide. Standard treatment strategies typically entail platinum‐based chemotherapy in conjunction with cytoreductive surgery.
Zunera Khalid +4 more
wiley +1 more source
Generation of RB1 knockout human embryonic stem cell lines derived from H9 using CRISPR/Cas9
Stem Cell ResearchRB1 is a tumor suppressor gene which plays a crucial role in cell cycle and cellular differentiation. Mutations or loss of RB1 are associated with retinoblastoma and a variety of other cancers.
Jinyi Wang +4 more
doaj +1 more source
Generation of a Retinoblastoma (Rb)1-inducible dominant negative (DN) mouse model
Frontiers in Cellular Neuroscience, 2015 Retinoblastoma 1 (Rb1) is an essential gene regulating cellular proliferation, differentiation, and homeostasis. To exert these functions, Rb1 is recruited and physically interacts with a growing variety of signaling pathways.
Shikha eTarang +5 more
doaj +1 more source