Results 141 to 150 of about 107,123 (321)

Rb1 gene mutations in osteosarcoma

Chinese Journal of Cancer Research, 1999
Genetic alternations, such as mutations caused inactivities of tumor suppressor gene, have been identified in a wide variety of tumors, including osteosarcoma. Osteosarcoma is the most frequent primary malignant bone tumor that occurs in the extremities of young adolescents in most cases. Because of the high frequent occurrence of this type of tumor in
Zeng Ji-bin, Song Yue, Wang Yi, Shi Yu-yuan   +3 more
openaire   +1 more source

Interventional oncology in children: Where are we now?

Journal of Medical Imaging and Radiation Oncology, EarlyView.
Abstract Paediatric Interventional Oncology (IO) lags behind adult IO due to a scarcity of specific outcome data. The suboptimal way to evolve this field is relying heavily on adult experiences. The distinct tumour types prevalent in children, such as extracranial germ cell tumours, sarcomas, and neuroblastoma, differ strongly from those found in ...
Premal Amrishkumar Patel, Fernando Gómez Muñoz   +1 more
wiley   +1 more source

Ginsenoside Rb1 Enhances Atherosclerotic Plaque Stability by Improving Autophagy and Lipid Metabolism in Macrophage Foam Cells

Frontiers in Pharmacology, 2017
Atherosclerosis (AS) is a lipid-driven disease in which macrophage foam cells play a critical role by increasing vascular lipid accumulation and contributing to plaque instability. Ginsenoside Rb1 (Rb1), the most abundant active component of ginseng, has
Lei Qiao, Xue Zhang, Xue Zhang, Minghao Liu, Xiaoling Liu, Mei Dong, Jing Cheng, Xinyu Zhang, Chungang Zhai, Yu Song, Huixia Lu, Wenqiang Chen   +11 more
doaj   +1 more source

Translational potential of ginsenoside Rb1 in managing progression of osteoarthritis

, 2016
SummaryBackgroundOsteoarthritis (OA) is the most common degenerative joint disorder. Inflammatory cytokine plays an important role in OA progression.
Sun, Yuxin, Xiao, Liubin, Li, Gang, Ki Wai Ho, Zou, Liyi, Yuxin Sun, Yuanfeng Chen, Xiaohua Pan, Liyi Zou, Chen, Yuanfeng, Sien Lin, Gang Li, Pan, Xiaohua, Ho, Ki Wai, Lin, Sien, Liubin Xiao   +15 more
core   +1 more source

Progress of Ginsenoside Rb1 in neurological disorders

Frontiers in Pharmacology
Ginseng is frequently used in traditional Chinese medicine to treat neurological disorders. The primary active component of ginseng is ginsenoside, which has been classified into more than 110 types based on their chemical structures. Ginsenoside Rb1 (GsRb1)—a protopanaxadiol saponin and a typical ginseng component—exhibits anti-inflammatory, anti ...
Gongxia Ling, Min Zhang, Chizhang Chen, Yan Wang, Qiqi Gao, Jianshun Li, Hao Yuan, Wenwen Jin, Wei Lin, Lingrong Yang   +9 more
openaire   +3 more sources

Bridging the Late Antique Gap in Northwest Arabia: New Archaeological Evidence on the Occupation of Wādī al‐Qurā (al‐ʿUlā [AlUla], Saudi Arabia) Between the Third and Seventh Centuries CE

Arabian Archaeology and Epigraphy, EarlyView.
ABSTRACT In 2019, the Dadan Archaeological Project (CNRS/RCU/AFALULA) identified a Late Antique village 1 km south of ancient Dadan in the al‐ʿUlā valley (northwest Saudi Arabia). Three excavation seasons at this site (2021–2023) have uncovered a massive building constructed in the late third or early fourth cent.
Jérôme Rohmer, Abdulrahman Alsuhaibani, Charlène Bouchaud, Elora Chambraud, Vladimir Dabrowski, Hatem Djerbi, Fabien Lesguer, Hervé Monchot, Paul Picavet, Louise Purdue, Bertrand Riba, Shadi Shabo   +11 more
wiley   +1 more source

Management of Advanced Prostate Cancer in the Asia‐Pacific Region: Summary of the Asia‐Pacific Advanced Prostate Cancer Symposium 2025

Asia-Pacific Journal of Clinical Oncology, EarlyView.
Summary of the Asia Pacific Advanced Prostate Cancer Symposium 2025, showing disciplines and diversity of participants, discussion topics (high‐risk localized/locally advanced prostate cancer; PSA persistence and recurrence; radioligand therapy; genetics and genomics; bone protection and other aspects of supportive care), key themes, and high‐level ...
Edmund Chiong, Renu Eapen, Nicholas Buchan, Kenneth Chen, Lukman Hakim, Agus Rizal Hamid, Jae‐Young Joung, Ravindran Kanesvaran, Makarand Khochikar, Jason Letran, Bannakij Lojanapiwat, Indranil Mallick, Chi Fai Ng, Pei Ing Ngam, Teng Aik Ong, Jacob Pang, Darren M. C. Poon, Natasha Roberts, Marniza Saad, Shinichi Sakamoto, Jeremy Tey, Sue Ping Thang, Poh Choo Toh, Levent Türkeri, Nguyễn Tuấn Vinh, Alvin Wong, Yao Zhu, ANZUP Cancer Trials Group, Ian D. Davis   +28 more
wiley   +1 more source

miR-222 promotes retinoblastoma cell proliferation and invasion by targeting RB1

Zhongguo aizheng zazhi, 2016
Background and purpose: A large number of studies have showed that retinoblastoma gene 1 (RB1) can inhibit the occurrence and development of many tumors, including neuroblastoma, small cell lung cancer, osteosarcoma, pancreatic cancer, breast cancer and ...
刘越峰, 张　勇, 钟晓东
doaj  

rb1 mRNA overexpression rescues optic nerve hypoplasia in rb1^te226 mutants.

, 2012
(A–B) Optic nerves of uninjected wild type (A) and rb1te226a; ath5:gfp+/− embryos (B) at 48 hpf. (C–D) Optic nerves of rb1te226a; ath5:gfp+/− embryos injected with 10 pg of wild type rb1 (C) or rb1te226a (D) mRNA.
Kristin Lorent (81822), Marc Wolman (116182), Michael Gyda (116179), Michael Granato (116187)   +3 more
core   +1 more source

Impact of Surgical Approach on Survival and Recurrence in Borderline and Malignant Phyllodes Tumours: A Systematic Review and Meta‐Analysis

ANZ Journal of Surgery, EarlyView.
ABSTRACT Background Phyllodes tumours of the breast exhibit a spectrum of biologic behaviour, with a predisposition to recur locally and metastasize distantly in their malignant form. There are limited data regarding the optimal surgical approach. Objectives Our systematic review and meta‐analysis aimed to determine the impact of breast conserving ...
Christopher G. Harris, Gillian Heller, Farhad Azimi, Belinda Chan, Susannah Graham, Cindy Mak, Sanjay Warrier   +6 more
wiley   +1 more source