Results 161 to 170 of about 107,123 (321)

Merkel Cell Carcinoma With Divergent Differentiation—Or Something Else? A Triphasic Cutaneous Carcinoma With Lineage Plasticity

Journal of Cutaneous Pathology, EarlyView.
ABSTRACT Merkel cell carcinoma (MCC) is a rare, aggressive cutaneous neuroendocrine carcinoma that typically arises in sun‐exposed skin of older or immunosuppressed patients. Combined or collision tumors involving MCC and other cutaneous malignancies are uncommon, and tumors exhibiting more than two distinct malignant phenotypes are exceptionally rare.
Zeinab Khalil, Hozaifa Elameen, Ahmed K. Alomari   +2 more
wiley   +1 more source

Effects of saponins Rb1 and Re in American ginseng combined intervention on immune system of aging model

Frontiers in Molecular Biosciences
Aging is a major risk factor for the development of many pathological processes, such as reduced immunity, cancer, cardiovascular diseases or neurodegenerative diseases, while age-related chronic diseases are the most common causes of death.
Mao Shi, Jie Ma, Shan Jin, Tienan Wang, Yuhan Sui, Lina Chen   +5 more
doaj   +1 more source

Defective TGF-β proliferative control in Rb1^ΔL/ΔL and Rb1^ΔL/+ mice.

, 2013
A) Rb1+/+, Rb1ΔL/+, and Rb1ΔL/ΔL mammary epithelial cells were treated with TGF-β1 and pulse labeled with BrdU 24 hrs later. The percentage of cells incorporating BrdU was measured by immunofluorescence microscopy.
Sarah M. Francis (355629), Subrata Chakrabarti (103000), Frederick A. Dick (355630)   +2 more
core   +1 more source

Cytology‐First Diagnostic Workflow for Melanoma of Unknown Primary With Molecular Profiling

Cytopathology, EarlyView.
Cytology‑first diagnostic workflow for melanoma of unknown primary. Fine‑needle aspiration of an enlarged lymph node enables rapid cytologic evaluation and immunocytochemical confirmation of melanocytic lineage (SOX10). This early cytologic diagnosis facilitates timely surgical excision and comprehensive genomic profiling, supporting integrated ...
Hong Yu, Mokhtar Abdelhammed, Xu Cao, Nisha S. Ramani   +3 more
wiley   +1 more source

Ginsenoside Rb1 Protects Against Diabetic Cardiomyopathy by Regulating the Adipocytokine Pathway [Corrigendum]

Zhang C, Han M, Zhang X, Tong H, Sun X, Sun G. J Inflamm Res. 2022;15:71–83. The authors have advised that due to an error that occurred inadvertently at the time of figure assembly, figure parts 3A on page 76 and 4B on page 77 are incorrect.
Han M, Zhang X, Tong H, Sun G, Zhang C, Sun X   +5 more
core  

Characterisation of retinoblastomas without RB1 mutations: genomic, gene expression, and clinical studies

, 2013
SummaryBackgroundRetinoblastoma is the childhood retinal cancer that defined tumour-suppressor genes. Previous work shows that mutation of both alleles of the RB1 retinoblastoma suppressor gene initiates disease.
Corson, Timothy W, Lam, Wan L, Lohmann, Dietmar, Prigoda-Lee, Nadia L, Rushlow, Diane E, Yee, Stephanie, Zacksenhaus, Eldad, Dorsman, Josephine C, Pajovic, Sanja, Raizis, Anthony, Gallie, Brenda L, Mol, Berber M, Paton, Katherine, Spencer, Clarellen, Boutros, Paul C, Jiang, Zhe, Godbout, Roseline, Halliday, William, Kennett, Jennifer Y, Moll, Annette C, Massey, Christine, Houdayer, Claude, Pang, Renée, Dimaras, Helen, Thériault, Brigitte L   +24 more
core   +1 more source

When Small Cells Matter: Diagnosing Bladder Small Cell Carcinoma on Urine Cytology

Cytopathology, EarlyView.
Small cell carcinoma of the bladder is rare, aggressive and diagnostically challenging on urine cytology. We report a case detected in urine and confirmed by cell block immunohistochemistry, highlighting the importance of careful assessment and limitations of the Paris System.
Haley Corbin, Samer Khader, Gabriela Quiroga‐Garza, Liron Pantanowitz   +3 more
wiley   +1 more source

The Rb1 tumour suppressor gene modifies telomeric chromatin architecture by regulating TERRA expression.

, 2017
The tumour suppressor gene (Rb1) is necessary for the maintenance of telomere integrity in osteoblastic cells. We now show that the compaction of telomeric chromatin and the appropriate histone modifications of telomeric DNA are both dependent upon Rb1 ...
S. Alonso-Rodriguez, Schneider, R., Alonso-Rodriguez, S., J. L. Fernández, Fernández, J.L., Sanli-Bonazzi, B., M. J. Atkinson, B. Sanli-Bonazzi, Gonzalez-Vasconcellos, I., Atkinson, M.J., I. Gonzalez-Vasconcellos, R. Schneider, N. Anastasov, Anastasov, N.   +13 more
core   +1 more source

Cutaneous Leiomyosarcoma of the Skin: An Updated Review of Epidemiology, Pathogenesis, and Management

International Journal of Dermatology, EarlyView.
This review provides an update on the epidemiology, pathogenesis, and clinical/histologic features of cutaneous leiomyosarcoma. Prognostic factors (e.g., depth of tumor involvement, grade, etc.) that can facilitate risk stratification are also discussed, as are treatment approaches for this rare malignancy.
Tejas P. Joshi, Natalie Garcia, Malak Husseinali, Nabeeha Engineer, Ikue Shimizu   +4 more
wiley   +1 more source

Complex Regulation of RETINOBLASTOMA‐RELATED's Interactions With E2Fs via Phosphorylation

Plant, Cell &Environment, EarlyView.
ABSTRACT Arabidopsis RETINOBLASTOMA‐RELATED (RBR) regulates cell proliferation by interacting with E2F transcription factors and DIMERISATION PARTNER, RB‐LIKE, E2F AND MULTI‐VULVAL CLASS B COMPLEX (DREAM) components. Although CDK‐CYCD phosphorylation is believed to affect RBR's E2F‐binding capacity, the precise phosphorylation events inhibiting RBR's ...
Aladár Pettkó‐Szandtner, Fruzsina Vadai‐Nagy, Magdolna Gombos, Attila Hlacs, Eszter Molnár, Annamária Marton, Csaba Vizler, Rasik Shiekh Bin Hamid, Péter Kaló, Attila Fehér, Zoltán Magyar   +10 more
wiley   +1 more source