Results 151 to 160 of about 107,123 (321)

Clinical and molecular features of primary gliosarcoma with digital spatial whole‐transcriptome analysis of glial and mesenchymal components

Brain Pathology, EarlyView.
We report the clinical and genetic features of an institutional cohort of primary adult gliosarcomas compared to glioblastoma. We performed spatial whole‐transcriptome analysis on glial and sarcomatous regions of four cases to compare gene expression profiles and validated differential protein expression for two markers in tissue sections.
Matthew D. Wood, Gabriel Zangirolani, Jinho Lee, Melanie H. Hakar, Tanaya Neff, Kevin Y. Zhang, Christopher L. Corless   +6 more
wiley   +1 more source

Ginsenoside Rb1 attenuates diabetic retinopathy in streptozotocin-induced diabetic rats

, 2019
Purpose: To investigated the effects of ginsenoside Rb1 on diabetic retinopathy in streptozotocin-induced diabetic rats. Methods: Diabetes was induced by a single intraperitoneal injection of streptozotocin (80 mg/kg) in male Wistar rats.
Peng Liu (120506), Changxia Dong (6426605), Huaizhou Wang (408181), Guangxin Li (3621617), Yuanbin Li (4686445), Mei Dong (157261)   +5 more
core   +1 more source

Notoginsenoside‐Fa mitigates vascular endothelial permeability via targeting SUGT1 to stabilize NLRP3 in a resting state

British Journal of Pharmacology, EarlyView.
Background and Purpose Notoginsenoside‐Fa (Noto‐Fa) is an emerging active compound derived from notoginseng with promise in treating cardiovascular diseases. The development of cardiovascular diseases is intricately linked to the damage of vascular endothelium and it is widely acknowledged that numerous chronic inflammation pathways, especially the ...
Xiao‐Ying Yu, Da‐Hao Mai, Xing‐Ming Zhong, Li‐Ting Huang, Lan‐Ting Fu, He‐Cai Wang, Ke Wang, Hai‐Yan Li, Qiu‐He Chen, Yang Chen   +9 more
wiley   +1 more source

Genetic Predictors of Progression and Skin Rash in Japanese mCSPC Patients Treated With Apalutamide: CUARTET Study

Cancer Science, EarlyView.
In patients with mCSPC treated with apalutamide plus ADT, baseline ctDNA predicted earlier progression to CRPC and worse overall survival. Exploratory genome‐wide analysis identified 12 SNPs associated with apalutamide‐related skin rash. ABSTRACT Despite promising evidence of the efficacy of the androgen deprivation therapy (ADT) plus apalutamide in ...
Masaki Shiota, Taku Naiki, Koji Hatano, Akira Yokomizo, Hiroaki Tsuchiya, Yoko Takahashi, Taku Nakayama, Masaki Yoshida, Hirotsugu Uemura   +8 more
wiley   +1 more source

Comprehensive Genomic Characterization Between Urothelial Carcinoma Subtypes/Divergent Differentiation (S/DD) and Pure Urothelial Carcinoma Using a Large-Scale Japanese Genomic Panel Dataset. [PDF]

Int J Urol
ABSTRACT Objectives Urothelial carcinoma (UC) is a common malignancy; however, UC subtypes/divergent differentiation (S/DD) accounts for only 10%–20% of overall cases. S/DD's aggressive biological behavior significantly affects its prognosis and therapeutic decision‐making; thus, elucidating its genomic landscape within UC is important.
Kobayashi G, Sekino Y, Miyamoto S, Kobatake K, Kitano H, Goto K, Goriki A, Hieda K, Hayashi T, Sentani K, Hinata N.   +10 more
europepmc   +2 more sources

RB1 gene: mechanisms of unconventional tumour predisposition

, 2020
Since its first discovery, a multitude of studies have focused on RB1 as a tumour suppressor gene. Despite the wide literature on the topic, some mechanisms of tumorigenesis remain to be clarified. RB1 mutations have been primary correlated to hereditary
Elisa Gelli
core  

Detection and reporting of RB1 promoter hypermethylation in diagnostic screening [PDF]

, 2018
BACKGROUND: RB1 gene screening aids clinical management and genetic counselling in retinoblastoma families. Here we present epigenetic changes identified during routine molecular RB1 screening of tumor and blood samples. Complications in interpreting RB1
Kolkiewicz, K, Hashim, S, Price, EA, Karaa, E, Scheimberg, I, Patel, R, Onadim, Z, Sagoo, MS, Reddy, MA   +8 more
core  

Decreased Expression of FAT4 Promotes Multiple Myeloma Proliferation and Migration by Targeting the Hippo/YAP Pathway

Cancer Science, EarlyView.
This study provides the first comprehensive characterization of the functional impact, and mechanistic role of FAT4 in MM. Our findings highlight the tumor‐suppressive role of FAT4 in MM and uncover a novel mechanism by which FAT4 regulates the Hippo/YAP pathway.
Lina Zhang, Na Shen, Xin Cheng, Qinglin Shi, Lijuan Chen, Xuxing Shen   +5 more
wiley   +1 more source

Rare Secondary Neoplasms Arising in Epidermal Nevus: A Case Series and Literature Review

Journal of Cutaneous Pathology, EarlyView.
ABSTRACT Malignant transformation is known to occur with many nevi, such as nevus sebaceus. However, cases of secondary tumors developing in an epidermal nevus (EN) are rare, with only a few case reports documented in the literature. We present three unique cases of syringocystadenoma papilliferum (SCAP), syringofibroadenoma, trichilemmoma, and basal ...
Haya A. Homsi, Melissa Piliang, Jennifer Lucas, Jennifer S. Ko, Steven D. Billings, Shira Ronen   +5 more
wiley   +1 more source

Repression by RB1 characterizes genes involved in the penultimate stage of erythroid development

, 2015
Retinoblastoma-1 (RB1), and the RB1-related proteins p107 and p130, are key regulators of the cell cycle. Although RB1 is required for normal erythroid development in vitro, it is largely dispensable for erythropoiesis in vivo.
Melanie R Loyd (825983), John J Morris (825985), Mindy S Randall (825984), Jayesh G Shah (825986), Paul A Ney (825987), Ji Zhang (70438)   +5 more
core   +1 more source