Results 111 to 120 of about 107,123 (321)
GLUT1 inhibition blocks growth of RB1-positive triple negative breast cancer
Nature Communications, 2019 Triple negative breast cancer (TNBC) is a deadly form of breast cancer due to the development of resistance to chemotherapy affecting over 30% of patients. New therapeutics and companion biomarkers are urgently needed. Recognizing the elevated expression
Qin Wu +22 more
semanticscholar +1 more source
FOS3D: A Fluorescence‐Enabled Toolkit for Characterizing a Three‐dimensional Osteosarcoma Model
Advanced Science, EarlyView.FOS3D describes fluorescent (F) osteosarcoma (OS) cells in a tri‐dimensional (3D) model. The study comprises three phases: development, where biofabrication parameters are tuned to achieve cytocompatibility and tumor‐specific mechanical properties in cell‐laden gelatin methacryloyl constructs; validation, where whole‐well fluorescence reading is ...
William Humble +9 more
wiley +1 more source
RB1 controls differentiation through positive regulation of phosphoglycerate mutases
Cell Death and DiseaseMost glycolytic enzymes are transcriptionally controlled by hypoxia-inducible factor-1α (HIF-1α) and/or MYC, however, phosphoglycerate mutases (PGAMs) are exceptional.
Susumu Kohno +11 more
doaj +1 more source
Advanced Science, EarlyView.This study unveils a pathogenic axis in oral cancer where NUDT21 suppresses a tumor suppressor network, prominently PTEN, via 3'UTR lengthening. To exploit this transcriptomic vulnerability, we developed a biomimetic Nano‐APA‐editor. By delivering CRISPR/Cas9, we reprogrammed the global 3'UTR landscape, restoring multi‐target tumor suppression and ...
Yiran Ao +5 more
wiley +1 more source
Stem Cell Reports, 2017 Human embryonic stem cells (hESCs) provide a platform for studying human development and understanding mechanisms underlying diseases. Retinoblastoma-1 (RB1) is a key regulator of cell cycling, of which biallelic inactivation initiates retinoblastoma ...
Yishai Avior +3 more
doaj +1 more source
Ginsenoside Rb1 as an Anti-Diabetic Agent and Its Underlying Mechanism Analysis
Cells, 2019 Panax ginseng and Panax notoginseng, two well-known medical plants with economic value, have a long history of use for managing various diseases in Asian countries.
P. Zhou +6 more
semanticscholar +1 more source
Efficacy, safety and cost‐effectiveness of CAR‐T therapy
British Journal of Clinical Pharmacology, EarlyView.CAR T‐cells demonstrate high efficacy in blood cancers, including ALL, MM and DLBCL. Innovations target solid tumours despite challenges such as antigen escape. Combination therapies enhance the delivery and infiltration of CAR T cells. Toxicity, cost and resistance remain major barriers to clinical use.
Emina Karahmet Sher +7 more
wiley +1 more source
RB1: a prototype tumor suppressor and an enigma [PDF]
Genes & Development, 2016 The retinoblastoma susceptibility gene (RB1) was the first tumor suppressor gene to be molecularly defined.RB1mutations occur in almost all familial and sporadic forms of retinoblastoma, and this gene is mutated at variable frequencies in a variety of other human cancers.
openaire +2 more sources
Business Strategy and the Environment, EarlyView.ABSTRACT Although firms that integrate a sustainability orientation (SO) may experience a significant improvement in their resource efficiency, many, particularly small‐ and medium‐sized enterprises (SMEs), still struggle with the complexities of incorporating sustainability into their business models.
Michael Adu Kwarteng +3 more
wiley +1 more source
Development of RB1 mutation detection method based on mRNA
, 2016 Retinoblastoma (Rb) is a malignant tumor of the retina, occurring usually in children before age five. The heritable form acounting for about 40% of Rb making genetic analysis of RB1 gene is a important part of disease management.
Nguyễn Thị Xuân +4 more
core +1 more source