Results 31 to 40 of about 40,097 (234)
Transcriptome analysis reveals molecularly distinct subtypes in retinoblastoma
Scientific Reports, 2023 Retinoblastoma is the most frequent intraocular malignancy in children. Little is known on the molecular basis underlying the biological and clinical behavior of this cancer. Here, using gene expression profiles, we demonstrate the existence of two major
Qi Zeng, Sha Wang, Lu Chen, Jinwei Wang
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Біологічні студії, 2011 Hypoxia and ischemia, as well as endoplasmic reticulum stress, are principal factors which are necessary for tumor neovascularization and growth. We have studied the effect of blocking the endoplasmic reticulum – nuclei-1, the main signaling enzyme of ...
D. O. Minchenko +4 more
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Neoplasia: An International Journal for Oncology Research, 2017 Although mice models rank among the most widely used tools for understanding human genetics, biology, and diseases, differences between orthologous genes among species as close as mammals are possible, particularly in orthologous gene pairs in which one ...
Nicola Alessio +8 more
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Epigenetic Reprogramming by Decitabine in Retinoblastoma
Frontiers in Bioscience-LandmarkIntroduction: Retinoblastoma (Rb) is a rare cancer, yet it is the most common eye tumor in children. It can occur in either a familial or sporadic form, with the sporadic variant being more prevalent, though its downstream effects on ...
Lisa Gherardini +3 more
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High-Level MYCN-Amplified RB1-Proficient Retinoblastoma Tumors Retain Distinct Molecular Signatures
Ophthalmology Science, 2022 Purpose: Retinoblastomas are malignant eye tumors diagnosed in young children. Most retinoblastomas are genetically characterized by biallelic inactivation of the RB1 gene.
Khashayar Roohollahi, MSc +5 more
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RB1 gene mutations in retinoblastoma [PDF]
Human Mutation, 1999 Mutations in both alleles of the RB1 gene are causal for the development of retinoblastoma, a childhood tumor of the eye. The spectrum of somatic and germline mutations in this gene is dominated by small mutations. Data on small mutations are listed in a locus specific database available at http://www.d-lohmann.de/Rb/mutations.html.
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Retinoblastoma and its binding partner MSI1 control imprinting in Arabidopsis. [PDF]
PLoS Biology, 2008 Parental genomic imprinting causes preferential expression of one of the two parental alleles. In mammals, differential sex-dependent deposition of silencing DNA methylation marks during gametogenesis initiates a new cycle of imprinting. Parental genomic
Pauline E Jullien +5 more
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Bioinformatics analyses of retinoblastoma reveal the retinoblastoma progression subtypes [PDF]
PeerJ, 2020 Introduction Retinoblastoma (RB) is one common pediatric malignant tumor with dismal outcomes. Heterogeneity of RB and subtypes of RB were identified but the association between the subtypes of RB and RB progression have not been fully investigated ...
Manjing Cao +3 more
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The retinoblastoma gene family in differentiation and development [PDF]
Oncogene, 1999 The retinoblastoma (Rb) tumor suppressor gene and its close relatives p107 and p130 are best known for their function in the control of cell cycle progression. In recent years, however, a new role for these proteins has been emerging as they have been linked with regulation of terminal differentiation of many tissues and cell types. In fact, Rb and its
M M, Lipinski, T, Jacks
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Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
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