Results 11 to 20 of about 342,913 (296)

Tumor Suppressor Genes [PDF]

Research Journal of Medical Sciences, 2010
Tumour suppressor genes are a class of genes that have a crucial role in the genesis of neoplasia. These genes when transcribed and translated, result in the production of proteins that regulate the cell cycle, repair any DNA mutations and control apoptosis.
Gamudi, Donia, Blundell, Renald
openaire   +4 more sources

Genome-wide screening of tumor suppressor genes in oncogenic transformation of normal lung epithelial cells and preliminary validation in sample databases

Di-san junyi daxue xuebao, 2022
Objective To identify new human lung cancer suppressors in a genome-wide screening library during neoplastic transformation of normal human lung epithelial cells using CRISPR/Cas9-mediated genome editing, and preliminarily validate the Results in non ...
ZHAO Binyu, ZHANG Junlei, WANG Jiaqi, RUAN Yan, ZHANG Yue, LIU Lianlian   +5 more
doaj   +1 more source

Molecular Genetics of Esophageal Cancer : Indian Perspective

Asian Pacific Journal of Cancer Biology, 2021
Background: RIZ1 is one of the tumor-suppressor genes that is silenced in many human cancers. Change in RIZ1 expression has not been reported in ESCC patients.
Suddhasattwa Ray, Mona Malekzadehmoghani, Sonia S Ray, Partha Sen, Sayan Chakraborty   +4 more
doaj   +1 more source

Retinoblastoma Protein Paralogs and Tumor Suppression

Frontiers in Genetics, 2022
The retinoblastoma susceptibility gene (RB1) is the first tumor suppressor gene discovered and a prototype for understanding regulatory networks that function in opposition to oncogenic stimuli.
Mauricio Flores, David W. Goodrich
doaj   +1 more source

Promoter Methylation of Tumor Suppressors in Thyroid Carcinoma: A Systematic Review

Iranian Journal of Public Health, 2021
Background: The tumor suppressor genes play a critical role in cellular and molecular mechanisms such as cell cycle processes, cell differentiation and apoptosis.
Sara Sheikkholeslami, Marjan Zarif -Yeganeh, Samaneh Farashi, Fereidoun Azizi, Sima Kheradmand Kia, Ladan Teimoori-Toolabi, Mehdi Hedayati   +6 more
doaj   +1 more source

Pan-cancer analysis of biallelic inactivation in tumor suppressor genes identifies KEAP1 zygosity as a predictive biomarker in lung cancer [PDF]

Cell
Maria A Perry, Ed Reznik, Chaitanya Bandlamudi   +2 more
exaly   +2 more sources

G‐quadruplex‐enhanced circular single‐stranded DNA (G4‐CSSD) adsorption of miRNA to inhibit colon cancer progression

Cancer Medicine, 2023
Background Chromosomal heterogeneity leads to the abnormal expression and mutation of tumor‐specific genes. Drugs targeting oncogenes have been extensively developed.
Haidong Wu, Weilong Zhong, Ronghua Zhang, Yuping Ding, Chunhua Qu, Keguan Lai, Zheng Pang, Shan Yin, Guangling Zhang, Shuang Chen   +9 more
doaj   +1 more source

Significance of promoter methylation of multiple tumor suppressor genes in hepatocellular carcinoma

Egyptian Journal of Medical Human Genetics, 2022
Background Methylation of the promoter at CpG islands is a mechanism of silencing tumor suppressor genes and therefore enhances cancer progression.
Alaa Tahoon, Doaa El-Khateeb, Asmaa Mosbeh, Ibrahim Tantawy El Sayed, Ashraf Khalil   +4 more
doaj   +1 more source

Oncogenes and Tumor-Suppressor Genes [PDF]

Environmental Health Perspectives, 1991
The functional role of oncogenes in human lung carcinogenesis has been investigated by transfer of activated oncogenes into normal cells or an immortalized bronchial epithelial cell line, BEAS-2B. Transfection of v-Ha-ras, Ki-ras, or the combination of myc and raf into BEAS-2B cells produced tumorigenic cell lines, while transfection of raf or myc ...
T A, Lehman, R, Reddel, A M, Peiifer, E, Spillare, M E, Kaighn, A, Weston, B I, Gerwin, C C, Harris   +7 more
openaire   +2 more sources

UBE2QL1 is Disrupted by a Constitutional Translocation Associated with Renal Tumor Predisposition and is a Novel Candidate Renal Tumor Suppressor Gene [PDF]

, 2013
Investigation of rare familial forms of renal cell carcinoma (RCC) has led to the identification of genes such as VHL and MET that are also implicated in the pathogenesis of sporadic RCC. In order to identify a novel candidate renal tumor suppressor gene,
Hodgson, S, Morris, Mark R., Turnell, Andrew S., Woodward, ER, Prigmore, Elena, Woodward, Emma R.; id_orcid, Wake, NC, Wake, Naomi C., Gribble, Susan M., Ricketts, Christopher J., Skytte, AB, Brown, Michael, Banks, RE, Morris, MR, Prigmore, E, Maher, ER, Woodward, Emma R., Clarke, Noel, Hodgson, Shirley, Skytte, Anne-bine, Ricketts, CJ, Turnell, AS, Brown, Michael; id_orcid, Maher, Eamonn R., Clarke, N, Banks, Rosamonde E., Gribble, SM, Brown, M, Skytte, Anne Bine   +28 more
core   +1 more source