Results 81 to 90 of about 12,054,912 (243)

A soluble activator that favors the ex vivo expansion of CD8+CD27+ T cells

JCI Insight, 2020
Adoptive cell therapy involves the infusion of tumor-reactive T cells into patients with cancer to provide antitumor immunity. The ex vivo expansion and differentiation of such T cells are key parameters that affect their therapeutic potential.
Esther I. Matus, Amanda Sparkes, Jean Gariépy   +2 more
doaj   +1 more source

Optimum Biasing for Cell Load Balancing Under QoS and Interference Management in HetNets

IEEE Access, 2016
In this paper, we consider a network in which lower power nodes (LPNs) are deployed jointly within macrocells. However, there are significant differences between the transmit power levels, coverage areas, and deployment densities of these two types of ...
Edenalisoa Rakotomanana, Francois Gagnon
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Identifiability and privacy in pluripotent stem cell research [PDF]

, 2014
Data sharing is an essential element of research; however, recent scientific and social developments have challenged conventional methods for protecting privacy.
Williams, C, Bredenoord, AL, Rooke, Heather, Isasi, R;Andrews, PW;Baltz, JM;Bredenoord, AL;Burton, P;Chiu, IM;Hull, SC;Jung, JW;Kurtz, A;Lomax, G;Ludwig, T;McDonald, M;Morris, C;Ng, HH;Rooke, H;Sharma, A;Stacey, GN;Williams, C;Zeng, F;Knoppers, BM, Baltz, Jay M, Sharma, A, Zeng, F, Ludwig, Tenneille, Kurtz, A, Morris, Clive, Ng, HH, Isasi, Rosario, McDonald, M, Kurtz, Andreas, Burton, P, Zeng, Fanyi, Chiu, Ing-Ming, Andrews, Peter W, Morris, C, Jung, J-W, Lomax, Geoffrey, Burton, Paul, Lomax, G, Sharma, Alka, Hull, SC, Chiu, I-M, Bredenoord, Annelien L, Andrews, PW, Stacey, GN, McDonald, Michael, Stacey, Glyn N, Jung, Ji-Won, Ludwig, T, Rooke, H, Knoppers, BM, Williams, Clare, Isasi, R, Baltz, JM, Baltz, Jay M., Andrews, Peter W., Ng, Huck Hui, Stacey, Glyn N., Bredenoord, Annelien L., Knoppers, Bartha Maria, Hull, Sara Chandros   +44 more
core   +1 more source

Dynein-Based Accumulation of Membranes Regulates Nuclear Expansion in Xenopus laevis Egg Extracts

SummaryNuclear size changes dynamically during development and has long been observed to correlate with the space surrounding the nucleus, as well as with the volume of the cell.
Hara, Yuki, Merten, Christoph
core   +2 more sources

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Avian Influenza Viruses: Global Panzootic, Host Range Expansion and Emerging One-Health Threats

Veterinary Sciences
The review deals with the current knowledge on the global panzootic spread of highly pathogenic avian influenza viruses (HPAIVs), with an emphasis on the H5N1 clade 2.3.4.4b virus.
Luigi Bruno, Maria Anna Nappo, Raffaele Frontoso, Salvatore Montinaro, Rosanna Di Lecce, Chiara Guarnieri, Luca Ferrari, Attilio Corradi   +7 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Commercial Production of Autologous Stem Cells and Their Therapeutic Potential for Liver Cirrhosis

Cell Transplantation, 2017
Human adipose-derived stem cells (hADSCs) are a promising source of autologous stem cells for personalized cell-based therapies. Culture expansion of ADSCs provides an attractive opportunity for liver cirrhosis patients.
Yi-Chun Lin, Horng-Jyh Harn M.D., Ph.D., Po-Cheng Lin, Ming-Hsi Chuang, Chun-Hung Chen, Shinn-Zong Lin, Tzyy-Wen Chiou Ph.D.   +6 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source