Results 131 to 140 of about 13,519,306 (307)

A Case Series on Minimally Invasive Upper Arm Contouring: Efficacy of Combined Renuvion Helium Plasma and Icoone Multi‐Micro Alveolar Stimulation for Fat Reduction

Clinical Case Reports
The combination of Renuvion helium plasma and Icoone Multi Micro Alveolar Stimulation is an effective, minimally invasive approach for reducing upper arm fat and improving skin texture.
Mohammad Ali Nilforoushzadeh, Alireza Jafarzadeh, Tannaz Fakhim, Masoumeh Mohamadi, Fereshteh Salarvand, Farnaz Parvaresh, Niloufar Najar Nobari   +6 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Diminished Schwann cell repair responses underlie age-associated impaired axonal regeneration.

Neuron, 2014
Michio W. Painter, Amanda Brosius Lutz, Yung‐Chih Cheng, Alban Latremoliere, Kelly Duong, Christine M. Miller, Sean Posada, E. Cobos, Alice Zhang, A. Wagers, L. Havton, B. Barres, T. Omura, C. Woolf   +13 more
semanticscholar   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Stem Cell Repair of the Microvascular Damage in Stroke. [PDF]

Cells, 2020
Saft M, Gonzales-Portillo B, Park YJ, Cozene B, Sadanandan N, Cho J, Garbuzova-Davis S, Borlongan CV.   +7 more
europepmc   +1 more source

CRISPR-edited human ES-derived oligodendrocyte progenitor cells improve remyelination in rodents

Nature Communications
In Multiple Sclerosis (MS), inflammatory demyelinated lesions in the brain and spinal cord lead to neurodegeneration and progressive disability. Remyelination can restore fast saltatory conduction and neuroprotection but is inefficient in MS especially ...
Laura J. Wagstaff, Nadine Bestard-Cuche, Maja Kaczmarek, Antonella Fidanza, Lorraine McNeil, Robin J. M. Franklin, Anna C. Williams   +6 more
doaj   +1 more source

Nuclear envelope rupture and repair during cancer cell migration

Science, 2016
C. Denais, R. Gilbert, Philipp Isermann, Alexandra L. McGregor, Mariska te Lindert, B. Weigelin, P. Davidson, P. Friedl, Katarina Wolf, J. Lammerding   +9 more
semanticscholar   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source