Results 211 to 220 of about 12,836,766 (354)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

IGFBP7 promotes endothelial cell repair in the recovery phase of acute lung injury. [PDF]

Clin Sci (Lond)
He R, Feng B, Zhang Y, Li Y, Wang D, Yu L.   +5 more
europepmc   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Elucidating the mechanism of corneal epithelial cell repair: unraveling the impact of growth factors. [PDF]

Front Med (Lausanne)
Gong J, Ding G, Hao Z, Li Y, Deng A, Zhang C.   +5 more
europepmc   +1 more source

Cell repair: Revisiting the patch hypothesis. [PDF]

Commun Integr Biol, 2016
Davenport NR, Bement WM.
europepmc   +1 more source

Fibroblast growth factor 2 regulation of mitral valve interstitial cell repair in vitro.

Journal of Thoracic and Cardiovascular Surgery, 2002
A. Gotlieb, A. Rosenthal, P. Kazemian
semanticscholar   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

The Nerve-Induced Adipose Stem Cells Promote Nerve Repair in Stress Urinary Incontinence by Regulating Schwann Cell Repair Phenotype Conversion Through Activation of the Notch Pathway. [PDF]

Mol Neurobiol
Liu M, Lu Y, Sun F, Li Y, Wu J, Zou Q.
europepmc   +1 more source

Eye Opener in Stroke. [PDF]

Stroke, 2019
Nguyen H, Lee JY, Sanberg PR, Napoli E, Borlongan CV.   +4 more
europepmc   +1 more source

Cell signalling / renal repair [PDF]

Nephrology Dialysis Transplantation, 2013
A. J. Sloan, A. Amaral, B. Walter, S. Singh, L. Barisoni, A. Fornoni, C. Faul, W. Neuhofer, C. Kueper, M.-L. Fraek, F.-X. Beck, J. Schodel, P. J. Ratcliffe, D. R. Mole, M. Gigante, P. Pontrelli, S. G. Netti, C. Divella, C. Cafiero, M. Accetturo, S. Simone, G. Grandaliano, L. Gesualdo, E. Ranieri, A. Zaravinos, G. I. Lambrou, N. Mourmouras, D. Delakas, C. C. Deltas   +28 more
openaire   +1 more source