Results 281 to 290 of about 12,836,766 (354)

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Superenhancers shape the landscape and repair dynamics of transcription-associated DNA breaks in cancer. [PDF]

Sci Adv
Hidmi O, Shatleh D, Flayshman SO, Monin J, Aqeilan RI.   +4 more
europepmc   +1 more source

Applications of Multifunctional Hydrogel in Tissue Engineering and Regenerative Medicine. [PDF]

MedComm (2020)
Lyu J, Liu X, Yang Q, Zhang Y, Wang X.
europepmc   +1 more source

Mesenchymal Stem Cell-Derived Exosomes: A Promising Therapeutic Strategy for Spinal Cord Injury. [PDF]

Int J Nanomedicine
Li X, Wang C, Du K, Wang J, Lin J, Yang C.   +5 more
europepmc   +1 more source

Translational Aspects of DNA Damage Repair in Optimizing Cancer Chemotherapy. [PDF]

Adv Genet (Hoboken)
Lin A, He J, Jiang A, Zhang J, Cheng Q, Zhang H, Mao W, Luo P.   +7 more
europepmc   +1 more source

Mesenchymal stem cell-derived extracellular matrix for musculoskeletal tissue regeneration. [PDF]

Commun Biol
Lv S, Wang J, Chen J, Yu Y, Huang X, Zhao G, Zhou X, Xu Y.   +7 more
europepmc   +1 more source

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Metabolic regulation of homologous recombination repair by MRE11 lactylation

Cell, 2023
Lactylation is a lactate-induced post-translational modification best known for its roles in epigenetic regulation. Herein, we demonstrate that MRE11, a crucial homologous recombination (HR) protein, is lactylated at K673 by the CBP acetyltransferase in ...
Yuping Chen, Jinhuan Wu, Linhui Zhai, Tingting Zhang, Hui Yin, Huanyao Gao, Fei Zhao, Zhe Wang, Xiaoning Yang, Mingpeng Jin, Bingsong Huang, Xin Ding, Rui Li, Jie Yang, Yiming He, Qianwen Wang, Weibin Wang, Jake A. Kloeber, Yunxuan Li, Bingbing Hao, Yuanyuan Zhang, Jiadong Wang, Minjia Tan, Ke Li, Ping Wang, Zhenkun Lou, Jian Yuan   +26 more
semanticscholar   +1 more source

Endothelial progenitor cell-derived exosomes facilitate vascular endothelial cell repair through shuttling miR-21-5p to modulate Thrombospondin-1 expression.

Clinical science, 2019
BACKGROUND Our previous studies observed that administration of exosomes from endothelial progenitor cell (EPC) facilitated vascular repair in rat model of balloon injury. However, the molecular events underling this process remain elusive.
Hui Hu, Boshi Wang, Chunyu Jiang, Ruiting Li, Jungong Zhao   +4 more
semanticscholar   +1 more source