Results 291 to 300 of about 12,836,766 (354)
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Clinics in Chest Medicine, 1981
Occupational lung disease results from a remarkably complex interaction of the inhaled material with the lung parenchyma and the worker's immune and inflammatory mechanism, (Fig 1). The past decade has seen a marked increase in our understanding of individual events involved in the pathogenesis of occupational lung disease, and has seen increased ...
E J, Campbell, R M, Senior
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Occupational lung disease results from a remarkably complex interaction of the inhaled material with the lung parenchyma and the worker's immune and inflammatory mechanism, (Fig 1). The past decade has seen a marked increase in our understanding of individual events involved in the pathogenesis of occupational lung disease, and has seen increased ...
E J, Campbell, R M, Senior
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Stem Cells and Myocardial Repair
Journal of the American College of Surgeons, 2002Myocardial ischemia sends a warning signal to subtended cardiomyocytes that can both promote protection by preconditioning and result in contractile dysfunction or stunning. If the ischemic period is brief ( 20 minutes), cardiomyocytes survive, contractile function recovers, and the myocardium becomes relatively resistant to subsequent ischemic insult.
Christopher D, Raeburn +4 more
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Stem cell mediated cardiovascular repair
Canadian Journal of Physiology and Pharmacology, 2012Recent increase in the interest in stem and progenitor cells may be attributed to their behavioural characteristics. A consensus has been reached that embryonic or adult stem cells have therapeutic potential. As cardiovascular health issues are still the major culprits in many developed countries, stem and progenitor cell driven approaches may give ...
Serkan, Durdu +6 more
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Current Opinion in Biotechnology, 2009
The liver has considerable inherent regenerative capacity through hepatocyte division and hepatic progenitor cell proliferation. In chronic disease regeneration eventually fails and liver transplantation is the only curative treatment. Current work aims to restore liver mass and functionality either through transplantation of stem cell derived ...
Janet W C, Kung, Stuart J, Forbes
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The liver has considerable inherent regenerative capacity through hepatocyte division and hepatic progenitor cell proliferation. In chronic disease regeneration eventually fails and liver transplantation is the only curative treatment. Current work aims to restore liver mass and functionality either through transplantation of stem cell derived ...
Janet W C, Kung, Stuart J, Forbes
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Current Opinion in Pharmacology, 2006
Advances in the treatment of acute myocardial infarction have led to increased survival but also an increase in those suffering from heart failure. The concept of adult progenitor cell therapy has grown from observations that cardiac function improves after injection of bone marrow-derived cells into infarcted regions in animal models. The mechanism of
Nicholas F, Grigoropoulos +1 more
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Advances in the treatment of acute myocardial infarction have led to increased survival but also an increase in those suffering from heart failure. The concept of adult progenitor cell therapy has grown from observations that cardiac function improves after injection of bone marrow-derived cells into infarcted regions in animal models. The mechanism of
Nicholas F, Grigoropoulos +1 more
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Programming cells for cardiac repair
Current Opinion in Biotechnology, 2017Because the heart is a poorly regenerative organ, there has been considerable interest in developing novel cell-based approaches to restore lost contractile function after myocardial infarction (MI). While a wide variety of candidate cell types have been tested in animal MI models, the vast majority of clinical trials have used adult stem cell types ...
Rocco, Romagnuolo, Michael A, Laflamme
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Mismatch repair in mammalian cells
BioEssays, 1990AbstractA vital process in maintaining a low genetic error rate is the removal of mismatched bases in DNA. The importance of this process in E. coli is demonstrated by the 100–1000 fold increase in mutation frequency observed in cells deficient in this repair system(1).
L A, Heywood, J F, Burke
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Progress in Retinal and Eye Research, 2004
Retinal stem cells (RSCs) are multipotent central nervous system (CNS) precursors that give rise to the retina during the course of development. RSCs are present in the embryonic eyecup of all vertebrate species and remain active in lower vertebrates throughout life.
Henry, Klassen +2 more
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Retinal stem cells (RSCs) are multipotent central nervous system (CNS) precursors that give rise to the retina during the course of development. RSCs are present in the embryonic eyecup of all vertebrate species and remain active in lower vertebrates throughout life.
Henry, Klassen +2 more
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DNA repair and cell repair: Are they related?
International Journal of Radiation Oncology*Biology*Physics, 1979Abstract Evidence of damage-repair processes is reviewed in connection with 3 types of cytotoxic cell treatments: X-radiation; far-ultraviolet (UV) (254 nm) light; and fluorescent light (FL) exposure of cells that had been grown in the presence of 5-bromodeoxyuridine (BUdR).
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Progenitor cells for cardiac repair
Seminars in Cell & Developmental Biology, 2007Repair of diseased or injured myocardium by cell-based therapies is likely to require a multi-pronged approach. New myocytes will need to be generated, integrated with existing myocardial tissue, and perfused with a newly acquired vascular system.
Sylvia M, Evans +2 more
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