Results 91 to 100 of about 742,619 (218)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gabor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Therapeatic evaluation and single cell analysis of adipose stromal vascular fraction isolation from a commercial cell separation system. [PDF]

Stem Cell Res Ther
Han S, Zhang Q, Lu F, Cai J.
europepmc   +1 more source

Fundamentals of integrated ferrohydrodynamic cell separation in circulating tumor cell isolation. [PDF]

Lab Chip, 2021
Liu Y, Zhao W, Cheng R, Harris BN, Murrow JR, Hodgson J, Egan M, Bankey A, Nikolinakos PG, Laver T, Meichner K, Mao L.   +11 more
europepmc   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

The DigH glycosyl hydrolase is conditionally required for daughter cell separation in <i>Escherichia coli</i>. [PDF]

J Bacteriol
Bryant JC, Robbs EJ, Kurilung A, Dinkel BA, Nookaew I, Jorgenson MA.   +5 more
europepmc   +1 more source

Surgery assistance system for continuous resection of brain tumors-proposal of continuous tumor resection forceps, tumor cell separation, dehydration, and isolation mechanism. [PDF]

Int J Comput Assist Radiol Surg, 2023
Koguchi T, Shimizu F, Nagame T, Goto Y, Iwasaki H, Hanafusa A, Takagi M, Mohamaddan S, Nomura K, Muragaki Y, Iseki H, Masamune K, Akitaya T.   +12 more
europepmc   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Particle and Cell Separation in Deterministic Lateral Displacement Arrays with Inverse L-Shaped Pillars. [PDF]

Micromachines (Basel)
Jiang H, Zhang F, Fan Z, Zhang C, Zhang Z.   +4 more
europepmc   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Human Lung Cell Separation Strategies for Translational Research. [PDF]

Am J Respir Cell Mol Biol
Fujino N, Yamada M, Saito T, Konno S, Sugiura H.   +4 more
europepmc   +1 more source