Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Modelling cell shape in 3D structured environments: A quantitative comparison with experiments. [PDF]
Link R +3 more
europepmc +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Identification of structural and regulatory cell-shape determinants in Haloferax volcanii. [PDF]
Schiller H +11 more
europepmc +1 more source
Experience shapes chandelier cell function and structure in the visual cortex
Koen Seignette +14 more
openalex +1 more source
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Anisotropic Cell Shape and Motion Coordinate Hindbrain Neuropore Morphogenesis
Pérez-Verdugo F +3 more
europepmc +1 more source
Quantifying the fractal complexity of nutrient transport channels in Escherichia coli biofilms under varying cell shape and growth environment. [PDF]
Bottura B +4 more
europepmc +1 more source
p38 MAPK-dependent shaping of the keratin cytoskeleton in cultured cells
Stefan Wöll +2 more
openalex +1 more source

