Results 91 to 100 of about 5,810,399 (215)

Willin, an upstream component of the Hippo signaling pathway, orchestrates mammalian peripheral nerve fibroblasts [PDF]

, 2013
Willin/FRMD6 was first identified in the rat sciatic nerve, which is composed of neurons, Schwann cells, and fibroblasts. Willin is an upstream component of the Hippo signaling pathway, which results in the inactivation of the transcriptional coactivator
Tilston-Lünel, A.M., Susan C Barnett, Gunn-Moore Frank J., Tilston-Lunel, Andrew Martin, Moleirinho, S., Jennifer R Higginson, Angus Liselotte, Prystowsky Michael B., Calum Patrick, Liselotte Angus, Andrew M. Tilston-lünel, Michael B. Prystowsky, Patrick, C., Susana Moleirinho, Frank J Gunn-Moore, Moleirinho Susana, Gunn-Moore, Frank J, Gunn-Moore, F.J., Prystowsky, M.B., Moleirinho, Susan, Paul A. Reynolds, Maciej Antkowiak, Susan C. Barnett, Jennifer R. Higginson, Antkowiak Maciej, Barnett Susan C., Paul A Reynolds, Higginson, J.R., Reynolds Paul A., Antkowiak, Maciej, Prystowsky, Michael, Michael B Prystowsky, Barnett, Susan, Antkowiak, M., Reynolds, Paul Andrew, Tilston-Lünel Andrew M., Barnett, S.C., Frank J. Gunn-moore, Angus, Liselotte, Andrew M Tilston-Lünel, Patrick Calum, Patrick, Calum, Higginson Jennifer R., Higginson, JR, Angus, L., Reynolds, P.A., Reynolds, Paul Andrew; id_orcid, Gunn-Moore, Frank J; id_orcid   +47 more
core   +2 more sources

COMPREHENSIVE OVERVIEW OF ADAPTOR PROTEIN RUK/CIN85 ROLES IN CANCER [PDF]

Biotechnologia Acta
Aim. This study is focused on a comprehensive overview of mechanisms and processes involved in the acquisition of cancer cell plasticity in a manner dependent on the adapter protein Ruk/CIN85 (in rodents, Ruk — regulator of ubiquitous kinase; in human ...
I. HORAK, T. SKATERNA, O. HUDKOVA1, N. LATYSHKO, O. KHUDIAKOVA, K. TOKARCHUK, I. KRYSIUK, T. KISHKO, L. KNOPFOV, Á L. DROBOT   +9 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Mast cell exosomes promote lung adenocarcinoma cell proliferation - role of KIT-stem cell factor signaling

, 2014
Background Human cells release nano-sized vesicles called exosomes, containing mRNA, miRNA and specific proteins. Exosomes from one cell can be taken up by another cell, which is a recently discovered cell-to-cell communication mechanism.
Lötvall, Jan,, Malmhäll, Carina,, Li, Li, Shelke, Ganesh V,, Lin, Jia, Lässer, Cecilia,, Lunavat, Taral R,, Lin, Lihui, Hui, Xiao,, Wang, Juan, Rådinger, Madeleine,   +10 more
core  

Spatiotemporal coordination of FGF and Shh signaling underlies the specification of myoblasts in the zebrafish embryo [PDF]

, 2018
Somitic cells give rise to a variety of cell types in response to Hh, BMP, and FGF signaling. Cell position within the developing zebrafish somite is highly dynamic: how, when, and where these signals specify cell fate is largely unknown.
Saunders, Timothy E., Lee, Raymond, Ingham, Philip W., Ingham, Philip William, Ono, Yosuke, Yin, Jianmin   +5 more
core   +1 more source

ATR Kinase Is a Crucial Player Mediating the DNA Damage Response in Trypanosoma brucei

Frontiers in Cell and Developmental Biology, 2020
DNA double-strand breaks (DSBs) are among the most deleterious lesions that threaten genome integrity. To address DSBs, eukaryotic cells of model organisms have evolved a complex network of cellular pathways that are able to detect DNA damage, activate a
Paula Andrea Marin, Ricardo Obonaga, Raphael Souza Pavani, Marcelo Santos da Silva, Christiane Bezerra de Araujo, André Arruda Lima, Carla Cristi Avila, Igor Cestari, Igor Cestari, Carlos Renato Machado, Maria Carolina Elias   +10 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

A Systems Approach for Decoding Mitochondrial Retrograde Signaling Pathways

, 2018
Mitochondrial dysfunctions activate retrograde signaling from mitochondria to the nucleus. To identify transcription factors and their associated pathways that underlie mitochondrial retrograde signaling, we performed gene expression profiling of the ...
Sehyun Chae, Cho, YM, Hwang, D, Lee, B, Ahn, BY, Park, KS, Byun, K, Yu, MH   +7 more
core   +1 more source

Glioblastoma Multiforme Stem Cell Cycle Arrest by Alkylaminophenol through the Modulation of EGFR and CSC Signaling Pathways

, 2020
Cancer stem cells (CSCs), a small subpopulation of cells existing in the tumor microenvironment promoting cell proliferation and growth. Targeting the stemness of the CSC population would offer a vital therapeutic opportunity.
Yli-Harja, Olli, Frank Emmert-Streib, Candeias, Nuno R, Vili Sipilä, Pekka Ruusuvuori, Phuong Doan, Nuno R. Candeias, Musa, Aliyu, Sipilä, Vili, Emmert-Streib, Frank, Ruusuvuori, Pekka, Doan, Phuong, Kandhavelu, Meenakshisundaram, Murugesan, Akshaya, Granberg, Kirsi, Olli Yli-Harja, Candeias, Nuno R., Aliyu Musa, Akshaya Murugesan, Kirsi Granberg, Meenakshisundaram Kandhavelu   +20 more
core   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source