Results 81 to 90 of about 2,233,123 (318)

Cell-to-cell signalling during pathogenesis [PDF]

Cellular Microbiology, 2009
Pathogenic bacteria produce virulence factors only when they sense they are in a location in which the energy required for pathogenesis is warranted. One environmental factor monitored by pathogens is population density, either of its own population or of the population of a host's endogenous flora. To date, four systems have been described which allow
Christopher T, Parker, Vanessa, Sperandio   +1 more
openaire   +2 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Metabolic sexual dimorphism in hypothalamic Fezf1 neuron-specific BDNF knockout

Biology of Sex Differences
Background Brain-derived neurotrophic factor (BDNF) is highly expressed in the hypothalamus where it exerts regulatory functions over neurogenesis, reproduction, energy balance, and metabolism.
Dayana Cabral-da-Silva, Ariane M. Zanesco, Fernando Valdivieso-Rivera, Ana L. Gallo-Ferraz, Marcela R. Simões, Bruna Bombassaro, Carlos H. Sponton, Licio A. Velloso   +7 more
doaj   +1 more source

LFA-1 activates focal adhesion kinases FAK1/PYK2 to generate LAT-GRB2-SKAP1 complexes that terminate T-cell conjugate formation

Nature Communications, 2017
The T-cell integrin LFA-1 binds ICAM-1 on antigen presenting cells to affect TCR-MHC interactions. Here the authors show detailed mechanics of how LFA-1 ligation affects T-cell conjugation to dendritic cells to regulate adhesion and de-adhesion of these ...
Monika Raab, Yuning Lu, Karsten Kohler, Xin Smith, Klaus Strebhardt, Christopher E. Rudd   +5 more
doaj   +1 more source

Cell Signaling in Neuronal Stem Cells [PDF]

Cells, 2018
The defining characteristic of neural stem cells (NSCs) is their ability to multiply through symmetric divisions and proliferation, and differentiation by asymmetric divisions, thus giving rise to different types of cells of the central nervous system (CNS).
Elkin Navarro Quiroz, Roberto Navarro Quiroz, Mostapha Ahmad, Lorena Gomez Escorcia, Jose Luis Villarreal, Cecilia Fernandez Ponce, Gustavo Aroca Martinez   +6 more
openaire   +5 more sources

Active growth signaling promotes senescence and cancer cell sensitivity to CDK7 inhibition

, 2023
Tumor growth is driven by continued cellular growth and proliferation. Cyclin-dependent kinase 7's (CDK7) role in activating mitotic CDKs and global gene expression makes it therefore an attractive target for cancer therapies.
Bertoli, Cosetta, Lauring, Josh, Vuina, Karla, Bertomeu, Thierry, Sava, Georgina, Huard, Caroline, Meneguello, Leticia, Kriston-Vizi, Janos, Maizels, Rory J, Tyers, Mike, de Bruin, Robertus AM, Wilson, Gemma A, Coulombe-Huntington, Jasmin, Ali, Simak   +13 more
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Formins in cell signaling

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2010
The founding formin homology protein family members were implicated early on as being involved in regulating cytoskeletal remodeling pathways, as formin protein mutations in Drosophila and yeast lead to obvious actin cytoskeleton defects. The discovery that these proteins associated directly with small Rho family GTPases confirmed these results and ...
Young, Kevin G., Copeland, John W.
openaire   +2 more sources

PACRG, a protein linked to ciliary motility, mediates cellular signaling. [PDF]

, 2016
Cilia are microtubule-based organelles that project from nearly all mammalian cell types. Motile cilia generate fluid flow, whereas nonmotile (primary) cilia are required for sensory physiology and modulate various signal transduction pathways.
Blacque, Oliver E, Bialas, Nathan J, Walker, D.S. (Denise S.), Schafer, WR, Dekkers, Martijn, Grundy, Laura J, Walker, DS, Li, Chunmei, Bialas, N.J. (Nathan), Walker, Denise S, Inglis, P.N. (P. Nick), Bialas, NJ, Dekkers, MPJ (Martijn), Li, C. (Chunmei), Loucks, CM, Schafer, William R, Inglis, P Nick, Kida, Katarzyna, Blacque, OE, Leroux, Michel R, Leroux, M.R. (Michel), Blacque, O.E. (Oliver), Kida, K. (Katarzyna), Grundy, L.J. (Laura J.), Inglis, PN, Leroux, MR, Kida, K, Loucks, C.M. (Catrina M.), Jansen, Gert, Dekkers, M.P.J. (Martijn), Li, CM, Loucks, Catrina M, Grundy, LJ, Schafer, W.R. (William), Jansen, G. (Gert)   +34 more
core   +1 more source

Store Operated Calcium Entry in Cell Migration and Cancer Metastasis

, 2021
Ca2+ signaling is ubiquitous in eukaryotic cells and modulates many cellular events including cell migration. Directional cell migration requires the polarization of both signaling and structural elements.
Khaled Machaca, Ayat S. Hammad
core   +1 more source