Results 61 to 70 of about 2,240,723 (318)

Oncogenic and Tumor-Suppressive Functions of NOTCH Signaling in Glioma [PDF]

, 2020
Although the role of NOTCH signaling has been extensively studied in health and disease, many questions still remain unresolved. Being crucial for tissue homeostasis, NOTCH signaling is also implicated in multiple cancers by either promoting or ...
Elena Parmigiani, Claudio Giachino, Verdon Taylor   +2 more
core   +1 more source

Central Nervous System Neuroblastoma, FOXR2‐Activated: A Pooled Analysis of Published Clinical Outcomes

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Central nervous system (CNS) neuroblastoma, FOXR2‐activated, is a recently recognized entity in the WHO CNS5 classification, defined by activation of the FOXR2 transcription factor and unique histopathological features. This review synthesizes available literature and pooled clinical data, providing insight into demographics ...
Sudarshawn Damodharan, Mohamed S. Abdelbaki   +1 more
wiley   +1 more source

Autocrine glutamate signaling drives cell competition in Drosophila. [PDF]

Cell competition is an evolutionarily conserved quality control process that eliminates suboptimal or potentially dangerous cells. Although differential metabolic states act as direct drivers of competition, how these are measured across tissues is not ...
Soares, CC, Maresma, MF, Rizzo, A, Meier, P   +3 more
core   +1 more source

The differential regulation of Lck kinase phosphorylation sites by CD45 is critical for T cell receptor signaling responses [PDF]

, 2007
The molecular mechanisms whereby the CD45 tyrosine phosphatase (PTPase) regulates T cell receptor (TCR) signaling responses remain to be elucidated. To investigate this question, we have reconstituted CD45 (encoded by Ptprc)-deficient mice, which display
Cooper, Joanne C, Alexander, Denis R, Cassady-Cain, Robin L., Salmond, Robert J., Tandon, Panna, Roche-Molina, Marta, Carret, Céline K., Holmes, Nick, McNeill, Louise, Cassady-Cain, Robin, Cooper, Joanne C., Alexander, Denis R., Carret, Celine K   +12 more
core   +1 more source

Absence of EPAC1 Signaling to Stabilize CFTR in Intestinal Organoids [PDF]

, 2022
The plasma membrane (PM) stability of the cystic fibrosis transmembrane conductance regulator (CFTR), the protein which when mutated causes Cystic Fibrosis (CF), relies on multiple interaction partners that connect CFTR to signaling pathways, including ...
Amaral, Margarida D., João F. Ferreira, Ferreira, João F., Silva, Iris A. L., Botelho, Hugo M., Iris A. L. Silva, Margarida D. Amaral, Carlos M. Farinha, Hugo M. Botelho, Farinha, Carlos M.   +9 more
core   +1 more source

Holo-Seq: single-cell sequencing of holo-transcriptome

Genome Biology, 2018
Current single-cell RNA-seq approaches are hindered by preamplification bias, loss of strand of origin information, and the inability to observe small-RNA and mRNA dual transcriptomes.
Zhengyun Xiao, Guo Cheng, Yang Jiao, Chen Pan, Ran Li, Danmei Jia, Jing Zhu, Chao Wu, Min Zheng, Junling Jia   +9 more
doaj   +1 more source

Feasibility and Safety of Somato‐Cognitive Coordination Therapy for Cerebellar Ataxia Following Pediatric Brain Tumor Treatment

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Cerebellar ataxia after pediatric brain tumor treatment can cause persistent gait, balance, and speech impairment, yet no established rehabilitation strategy exists. Somato‐cognitive coordination therapy (SCCT) is a virtual reality–guided intervention designed to promote sensorimotor integration through visually constrained reaching
Masanobu Takeuchi, Takashi Matsuzawa, Jun Yamanishi, Masahiro Yoshitomi, Junji Ikeda, Shin‐Ichi Tsujimoto, Yasuteru Yamaguchi, Norio Shiba, Dhroov Pathare, Ayumi Kato, Masahiko Hara   +10 more
wiley   +1 more source

The Role of “Adult‐Onset” Cancer Predisposition Genes in Pediatric Cancer: A Comprehensive Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Current literature estimates that 10% of pediatric cancers are caused by pathogenic or likely pathogenic (P/LP) germline variants in cancer predisposition genes (CPGs). Variants in CPGs thought to increase cancer risk exclusively during adulthood are referred to as “adult‐onset” CPGs (aoCPGs).
Maria Rozo, Miriam A. Bornhorst, Angela J. Waanders, Sara Zarnegar‐Lumley, Ashwin Lakshman Koppayi, Lucy A. Godley   +5 more
wiley   +1 more source

Mast cell exosomes promote lung adenocarcinoma cell proliferation - role of KIT-stem cell factor signaling [PDF]

, 2014
Background Human cells release nano-sized vesicles called exosomes, containing mRNA, miRNA and specific proteins. Exosomes from one cell can be taken up by another cell, which is a recently discovered cell-to-cell communication mechanism.
Lötvall, Jan,, Malmhäll, Carina,, Li, Li, Shelke, Ganesh V,, Lin, Jia, Lässer, Cecilia,, Lunavat, Taral R,, Lin, Lihui, Hui, Xiao,, Wang, Juan, Rådinger, Madeleine,   +10 more
core  

Inhibition of Non-Small Cell Lung Cancer Cells by Oxy210, an Oxysterol-Derivative that Antagonizes TGFβ and Hedgehog Signaling [PDF]

, 2019
Non-Small Cell Lung Cancer (NSCLC) is a common malignancy and leading cause of death by cancer. Metastasis and drug resistance are serious clinical problems encountered in NSCLC therapy.
Feng Wang, Liu-Ya Tang, Ying E. Zhang, Frank Stappenbeck, Farhad Parhami   +4 more
core   +1 more source