Results 41 to 50 of about 2,233,123 (318)

BRCA1 and cell signaling [PDF]

Oncogene, 2000
The breast cancer and ovarian cancer susceptibility gene BRCA1 encodes a nucleoprotein whose mutations or aberrant expression is associated with both inherited and sporadic cancers. Studies over the last 6 years have suggested that BRCA1 may function as a scaffold in the assembly of a multi-protein complex, which plays a role in gene transcription, DNA
Q, Wang, H, Zhang, R, Fishel, M I, Greene   +3 more
openaire   +2 more sources

Notch2 signaling in development and cancer [PDF]

, 2012
Notch signaling via cell to cell interaction is a key mechanism in regulating proliferation, cell fate decisions and survival of various cell types in both invertebrates and vertebrates.
Tchorz, Jan Stephan
core   +1 more source

Cells recognize osmotic stress through liquid–liquid phase separation lubricated with poly(ADP-ribose)

Nature Communications, 2021
Cells experience various osmotic perturbation, but cellular osmosensing mechanisms remain obscure. Here, the authors report that cells recognize osmotic stress from the inside through macromolecular crowding-driven and poly(ADP-ribose)-conditioned liquid–
Kengo Watanabe, Kazuhiro Morishita, Xiangyu Zhou, Shigeru Shiizaki, Yasuo Uchiyama, Masato Koike, Isao Naguro, Hidenori Ichijo   +7 more
doaj   +1 more source

Fibroblast Growth Factor Receptors (FGFRs) and Noncanonical Partners in Cancer Signaling

, 2021
Increasing evidence indicates that success of targeted therapies in the treatment of cancer is context-dependent and is influenced by a complex crosstalk between signaling pathways and between cell types in the tumor.
Chiara Francavilla, Michael P. Smith, Harriet R. Ferguson   +2 more
core   +1 more source

K+ Channel Tetramerization Domain 5 (KCTD5) Protein Regulates Cell Migration, Focal Adhesion Dynamics and Spreading through Modulation of Ca2+ Signaling and Rac1 Activity [PDF]

, 2020
Cell migration is critical for several physiological and pathophysiological processes. It depends on the coordinated action of kinases, phosphatases, Rho-GTPases proteins, and Ca2+ signaling.
Riquelme, Denise, Pablo Cruz, Denise Riquelme, Canales, Jimena, Oscar Cerda, Villacura Díaz, Nicolás Esteban, Leiva Salcedo, Elias, Nicolás Díaz, Elías Leiva-Salcedo, Cruz, Pablo, Cerda Arancibia, Óscar, Jimena Canales   +11 more
core   +1 more source

Signal Processing On Cell Complexes

ICASSP 2022 - 2022 IEEE International Conference on Acoustics, Speech and Signal Processing (ICASSP), 2022
5 pages, 3 ...
T. Mitchell Roddenberry, Michael T. Schaub, Mustafa Hajij   +2 more
openaire   +2 more sources

Gut Microbiota–Derived Metabolites as Potential Therapeutics in Mitochondrial Dysfunction-Driven Intestinal Inflammatory Diseases

Cellular Microbiology
Trial Registration: ClinicalTrials.gov identifier: NCT01473524 ...
Gayatri Reghu, Pardhipa Nandigam, Ashna Fathima, Trinath Jamma   +3 more
doaj   +1 more source

Oligomerization-primed coiled-coil domain interaction with Ubc13 confers processivity to TRAF6 ubiquitin ligase activity

Nature Communications, 2017
Ubiquitin ligase TRAF6 catalyzes assembly of free polyubiquitin chains for TAK1 activation in the IL-1R/TLR pathways, but the mechanism underlying its processivity is unclear.
Lin Hu, Jiafeng Xu, Xiaomei Xie, Yiwen Zhou, Panfeng Tao, Haidong Li, Xu Han, Chong Wang, Jian Liu, Pinglong Xu, Dante Neculai, Zongping Xia   +11 more
doaj   +1 more source

WAC Promotes Polo-like Kinase 1 Activation for Timely Mitotic Entry

Cell Reports, 2018
Summary: The key mitotic regulator Polo-like kinase 1 (Plk1) is activated during G2 phase by Aurora A kinase (AurkA)-mediated phosphorylation of its activation loop, which is important for timely mitotic entry.
Feifei Qi, Qinfu Chen, Hongxia Chen, Haiyan Yan, Binbin Chen, Xingfeng Xiang, Cai Liang, Qi Yi, Miao Zhang, Hankun Cheng, Zhenlei Zhang, Jun Huang, Fangwei Wang   +12 more
doaj   +1 more source

On the emergence and evolution of artificial cell signaling networks [PDF]

, 2007
This PhD project is concerned with the evolution of Cell Signaling Networks (CSNs) in silico. CSNs are complex biochemical networks responsible for the coordination of cellular activities.
Decraene, James
core