Results 21 to 30 of about 2,240,723 (318)

Interleukin-6 actions in the hypothalamus protects against obesity and is involved in the regulation of neurogenesis

Journal of Neuroinflammation, 2021
Background Interleukin-6 (IL6) produced in the context of exercise acts in the hypothalamus reducing obesity-associated inflammation and restoring the control of food intake and energy expenditure.
Vanessa C. Bobbo, Daiane F. Engel, Carlos Poblete Jara, Natalia F. Mendes, Roberta Haddad-Tovolli, Thais P. Prado, Davi Sidarta-Oliveira, Joseane Morari, Licio A. Velloso, Eliana P. Araujo   +9 more
doaj   +1 more source

Ubiquitylation and cell signaling [PDF]

The EMBO Journal, 2005
Ubiquitylation is an emerging mechanism implicated in a variety of nonproteolytic cellular functions. The attachment of a single ubiquitin (Ub) or poly-Ub (lysine 63) chains to proteins control gene transcription, DNA repair and replication, intracellular trafficking and virus budding.
Kaisa, Haglund, Ivan, Dikic
openaire   +2 more sources

Complementary PTM Profiling of Drug Response in Human Gastric Carcinoma by Immunoaffinity and IMAC Methods with Total Proteome Analysis

Proteomes, 2015
Gaining insight into normal cellular signaling and disease biology is a critical goal of proteomic analyses. The ability to perform these studies successfully to extract the maximum value and discovery of biologically relevant candidate biomarkers is ...
Matthew P. Stokes, Charles L. Farnsworth, Hongbo Gu, Xiaoying Jia, Camilla R. Worsfold, Vicky Yang, Jian Min Ren, Kimberly A. Lee, Jeffrey C. Silva   +8 more
doaj   +1 more source

Rhabdomyolysis attenuates activity of semicarbazide sensitive amine oxidase as the marker of nephropathy in diabetic rats [PDF]

The Ukrainian Biochemical Journal, 2022
Amine oxidases are involved in the progression of many diseases and their complications, including renal failure, due to the generation of the three toxic metabolites (H2O2, aldehydes, and ammonia) in the course of biogenic amines oxidative deamination ...
O. Hudkova, I. Krysiuk, L. Drobot, N. Latyshko   +3 more
doaj   +1 more source

Cell Signaling: An overview [PDF]

Oncogene, 1998
Signal transduction is one of the fundamental processes of living cells being second in importance only to cell division. From the unicellular organism to multicellular organism, evolution has molded a diverse array of novel motifs and mechanisms to ensure that cells can eciently adapt to their environment.
openaire   +2 more sources

CELL BIOLOGY AND SIGNALING [PDF]

Neuro-Oncology, 2010
The phylogenetically-conserved vertebrate transcription factor, NFIB, is an orchestrator of glial differentiation in the developing mammalian central nervous system. We found NFIB expression to be reduced in glioblastoma (GBM), the commonest and most lethal primary adult brain cancer, so investigated what effect increased expression of NFIB had on GBM.
M. Agarwal, R. Nitta, S. Dovat, G. Li, H. Arita, Y. Narita, S. Fukushima, K. Tateishi, Y. Matsushita, A. Yoshida, Y. Miyakita, M. Ohno, V. P. Collins, N. Kawahara, S. Shibui, K. Ichimura, S. A. Kahn, S. Gholamin, M.-P. Junier, H. Chneiweiss, I. Weissman, S. Mitra, S. Cheshier, T. Avril, A. Hamlat, P.-J. Le Reste, J. Mosser, V. Quillien, C. Carrato, A. Munoz-Marmol, L. Serrano, L. Pijuan, C. Hostalot, S. l. Villa, A. Ariza, O. Etxaniz, C. Balana, E. T. Benveniste, Y. Zheng, B. McFarland, D. Drygin, S. Bellis, M. Bredel, D. Lotsch, C. Engelmaier, S. Allerstorfer, M. Grusch, J. Pichler, S. Weis, J. Hainfellner, C. Marosi, S. Spiegl-Kreinecker, W. Berger, A. Bronisz, M. O. Nowicki, Y. Wang, K. Ansari, E. A. Chiocca, J. Godlewski, K. Brown, M. Kwatra, K. Brown, M. Kwatra, T. Bui, R. Nitta, G. Li, S. Zhu, D. Kozono, J. Li, D. Kushwaha, B. Carter, C. Chen, J. Schulte, M. Srikanth, S. Das, J. Zhang, J. Lathia, L. Yin, J. Rich, E. Olson, J. Kessler, A. Chenn, A. Cherry, B. Haas, Y. H. Lin, S.-E. Ong, N. Stella, C. P. Cifarelli, R. J. Griffin, D. Cong, W. Zhu, Y. Shi, P. Clark, J. Kuo, S. Hu, D. Sun, M. Bookland, N. Darbinian, A. Dey, M. Robitaille, M. Remke, D. Faury, C. Maier, A. Malhotra, N. Jabado, M. Taylor, S. Angers, A. Kenney, X. Ren, H. Zhou, M. Schur, A. Baweja, M. Singh, A. Erdreich-Epstein, J. Fu, D. Koul, J. Yao, N. Saito, S. Zheng, R. Verhaak, Z. Lu, W. K. A. Yung, G. Gomez, S. Volinia, C. Croce, C. Brennan, W. Cavenee, F. Furnari, S. G. Lopez, D. Qu, C. Petritsch, M. Gonzalez-Huarriz, G. Aldave, D. Ravi, A. Rubio, R. Diez-Valle, M. Marigil, P. Jauregi, B. Vera, A. A. d. l. Rocha, S. Tejada-Solis, M. M. Alonso, U. Gopal, J. Isaacs, M. Gruber-Olipitz, S. Dabral, S. Ramkissoon, A. Kung, E. Pak, J. Chung, M. Theisen, Y. Sun, V. Monrose, Y. Franchetti, Y. Sun, D. Shulman, N. Redjal, B. Tabak, R. Beroukhim, J. Zhao, S. Buonamici, K. Ligon, J. Kelleher, R. Segal, B. Haas, D. Canton, P. Diaz, J. Scott, N. Stella, K. Hara, T. Kageji, Y. Mizobuchi, K. Kitazato, T. Okazaki, T. Fujihara, K. Nakajima, H. Mure, K. Kuwayama, T. Hara, S. Nagahiro, L. Hill, H. Botfield, K. Hossain-Ibrahim, A. Logan, G. Cruickshank, Y. Liu, M. Gilbert, N. Kyprianou, V. Rangnekar, C. Horbinski, Y. Hu, C. Vo, Z. Li, C. Ke, N. Ru, K. R. Hess, M. E. Linskey, Y.-a. H. Zhou, F. Hu, K. Vinnakota, S. P. Niclou   +200 more
openaire   +3 more sources

Guard Cell Signaling [PDF]

Cell, 2001
The plant hormone abscisic acid (ABA) regulates the aperture of the stomatal pore. The recent identification of new intermediates involved in ABA signaling suggests that this complex pathway is organized as a module-based network.
openaire   +2 more sources

Cell signaling and cancer [PDF]

Genome Biology, 2007
A report on the Cancer Research UK London Research Institute Special Conference 'Signal Transduction', London, UK, 14-16 May 2007.
Bazigou, Eleni, Rallis, Charalampos
openaire   +3 more sources

A complete map of the Calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2) signaling pathway [PDF]

, 2021
Calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2) is a serine/threonine-protein kinase belonging to the Ca2+/calmodulin-dependent protein kinase subfamily.
Chatterjee, Aditi, Rex, D.A.B., Modi, Prashant Kumar, Najar, Mohd Altaf, Dagamajalu, Shobha, Agarwal, Nupur, Sankar, Uma, Prasad, T.S. Keshava, Karthikkeyan, Gayathree, Vijayakumar, Manavalan   +9 more
core   +1 more source

Signaling in the crowded cell

Current Opinion in Structural Biology, 2021
High-resolution technologies have clarified some of the principles underlying cellular actions. However, understanding how cells receive, communicate, and respond to signals is still challenging. Questions include how efficient regulation of assemblies, which execute cell actions at the nanoscales, transmits productively at micrometer scales ...
Ruth Nussinov, Chung-Jung Tsai, Hyunbum Jang   +2 more
openaire   +2 more sources