Results 21 to 30 of about 2,233,123 (318)
The plant hormone abscisic acid (ABA) regulates the aperture of the stomatal pore. The recent identification of new intermediates involved in ABA signaling suggests that this complex pathway is organized as a module-based network.
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Cell signaling and cancer [PDF]
A report on the Cancer Research UK London Research Institute Special Conference 'Signal Transduction', London, UK, 14-16 May 2007.
Bazigou, Eleni, Rallis, Charalampos
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NOTCH1 Signaling in Head and Neck Squamous Cell Carcinoma
Biomarker-driven targeted therapies are lacking for head and neck squamous cell carcinoma (HNSCC), which is common and lethal. Efforts to develop such therapies are hindered by a genomic landscape dominated by the loss of tumor suppressor function ...
Faye M. Johnson +7 more
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Role of the Tumor Microenvironment in Regulating Pancreatic Cancer Therapy Resistance
Pancreatic cancer has a notoriously poor prognosis, exhibits persistent drug resistance, and lacks a cure. Unique features of the pancreatic tumor microenvironment exacerbate tumorigenesis, metastasis, and therapy resistance. Recent studies emphasize the
Daiyong Deng +3 more
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High-resolution technologies have clarified some of the principles underlying cellular actions. However, understanding how cells receive, communicate, and respond to signals is still challenging. Questions include how efficient regulation of assemblies, which execute cell actions at the nanoscales, transmits productively at micrometer scales ...
Ruth Nussinov +2 more
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Evolving artificial cell signaling networks using molecular classifier systems [PDF]
Nature is a source of inspiration for computational techniques which have been successfully applied to a wide variety of complex application domains. In keeping with this we examine Cell Signaling Networks (CSN) which are chemical networks responsible ...
James Decraene +5 more
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The p53 family member p73 in the regulation of cell stress response
During oncogenesis, cells become unrestrictedly proliferative thereby altering the tissue homeostasis and resulting in subsequent hyperplasia. This process is paralleled by resumption of cell cycle, aberrant DNA repair and blunting the apoptotic program ...
Julian M. Rozenberg +13 more
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Automated single-molecule imaging in living cells
Large scale live cell screens often lack single-molecule resolution. Here the authors present an artificial intelligence-assisted TIRF microscope with automated cell searching and focusing, and use it for high-throughput single-molecule imaging of EGFR ...
Masato Yasui +4 more
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Cell Signaling in Neurodegeneration
Neurodegenerative diseases are characterized by the progressive loss of specific subsets of neurons [...]
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The knowledge about the molecular alterations which are found in head and neck squamous cell carcinomas (HNSCC) has much increased in recent years. However, we are still awaiting the translation of this knowledge to new diagnostic and therapeutic options.
Jarosław Paluszczak
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