Results 21 to 30 of about 5,810,399 (215)
Active growth signaling promotes senescence and cancer cell sensitivity to CDK7 inhibition [PDF]
, 2023 Tumor growth is driven by continued cellular growth and proliferation. Cyclin-dependent kinase 7's (CDK7) role in activating mitotic CDKs and global gene expression makes it therefore an attractive target for cancer therapies.
Bertoli, Cosetta +13 more
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Cell mechanotransduction machinery, and signaling defects: small tools and nano-bio interface for influential regenerative remedies [PDF]
, 2021 © 2021 The Authors. Published by Longdom Publishing. This is an open access article available under a Creative Commons licence. The published version can be accessed at the following link on the publisher’s website: https://www.longdom.org/open-access ...
Kumar, Rajiv, Gulia, Kiran
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Proteomes, 2015 Gaining insight into normal cellular signaling and disease biology is a critical goal of proteomic analyses. The ability to perform these studies successfully to extract the maximum value and discovery of biologically relevant candidate biomarkers is ...
Matthew P. Stokes +8 more
doaj +1 more source
Rhabdomyolysis attenuates activity of semicarbazide sensitive amine oxidase as the marker of nephropathy in diabetic rats [PDF]
The Ukrainian Biochemical Journal, 2022 Amine oxidases are involved in the progression of many diseases and their complications, including renal failure, due to the generation of the three toxic metabolites (H2O2, aldehydes, and ammonia) in the course of biogenic amines oxidative deamination ...
O. Hudkova +3 more
doaj +1 more source
Hedgehog Signaling in Cortical Development [PDF]
, 2023 The Hedgehog (Hh) pathway plays a crucial role in embryonic development, acting both as a morphogenic signal that organizes tissue formation and a potent mitogenic signal driving cell proliferation.
Xuecai Ge +5 more
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, 2023 Cervical cancer is the most prevalent gynecological tumor among women worldwide. Although the incidence and mortality of cervical cancer have been declining thanks to the wide-scale implementation of cytological screening, it remains a major challenge in
Jun Zhang +5 more
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Developmental ERK Signaling Goes Digital. [PDF]
, 2017 Reporting in Developmental Cell, de la Cova et al. (2017) present a biosensor to measure ERK activity dynamics in C. elegans larvae. They find that fate decision signaling involves frequency-modulated, digital ERK activity pulses.
Dessauges, Coralie, Pertz, Olivier
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The p53 family member p73 in the regulation of cell stress response
Biology Direct, 2021 During oncogenesis, cells become unrestrictedly proliferative thereby altering the tissue homeostasis and resulting in subsequent hyperplasia. This process is paralleled by resumption of cell cycle, aberrant DNA repair and blunting the apoptotic program ...
Julian M. Rozenberg +13 more
doaj +1 more source
Role of the Tumor Microenvironment in Regulating Pancreatic Cancer Therapy Resistance
Cells, 2022 Pancreatic cancer has a notoriously poor prognosis, exhibits persistent drug resistance, and lacks a cure. Unique features of the pancreatic tumor microenvironment exacerbate tumorigenesis, metastasis, and therapy resistance. Recent studies emphasize the
Daiyong Deng +3 more
doaj +1 more source
On the emergence and evolution of artificial cell signaling networks [PDF]
, 2007 This PhD project is concerned with the evolution of Cell Signaling Networks (CSNs) in silico. CSNs are complex biochemical networks responsible for the coordination of cellular activities.
Decraene, James
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