Results 1 to 10 of about 3,030,328 (299)

Engineering cell–cell signaling [PDF]

Current Opinion in Biotechnology, 2013
Juxtacrine cell-cell signaling mediated by the direct interaction of adjoining mammalian cells is arguably the mode of cell communication that is most recalcitrant to engineering. Overcoming this challenge is crucial for progress in biomedical applications, such as tissue engineering, regenerative medicine, immune system engineering and therapeutic ...
Katarina, Blagovic, Emily S, Gong, Daniel F, Milano, Robert J, Natividad, Anand R, Asthagiri   +4 more
openaire   +2 more sources

Androgen signaling uses a writer and a reader of ADP-ribosylation to regulate protein complex assembly

Nature Communications, 2021
Androgen receptor (AR) signaling is regulated by multiple post-translational modifications. Here, the authors identify the writer and reader enzymes for AR ADP-ribosylation and show how they modulate AR signaling output in prostate cancer cells.
Chun-Song Yang, Kasey Jividen, Teddy Kamata, Natalia Dworak, Luke Oostdyk, Bartlomiej Remlein, Yasin Pourfarjam, In-Kwon Kim, Kang-Ping Du, Tarek Abbas, Nicholas E. Sherman, David Wotton, Bryce M. Paschal   +12 more
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Pan-cancer predictions of transcription factors mediating aberrant DNA methylation

Epigenetics & Chromatin, 2022
Background Aberrant DNA methylation is a hallmark of cancer cells. However, the mechanisms underlying changes in DNA methylation remain elusive. Transcription factors initially thought to be repressed from binding by DNA methylation, have recently ...
Dylane Detilleux, Yannick G. Spill, Delphine Balaramane, Michaël Weber, Anaïs Flore Bardet   +4 more
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Cell signaling

Annals of the New York Academy of Sciences, 2010
This review explores advances in our understanding of dynamicism in cellular signaling. Areas highlighted include the role of stochasticity in producing diversity in analogous signaling circumstances; population desynchronization's effect in masking newly appreciated repetitive bursts in protein phosphorylation and messenger RNA production; double ...
Jameel, Iqbal, Mone, Zaidi, Narayan G, Avadhani   +2 more
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Cell Death Signaling [PDF]

Cold Spring Harbor Perspectives in Biology, 2015
In multicellular organisms, cell death is a critical and active process that maintains tissue homeostasis and eliminates potentially harmful cells. There are three major types of morphologically distinct cell death: apoptosis (type I cell death), autophagic cell death (type II), and necrosis (type III).
Douglas R, Green, Fabien, Llambi
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Cell signalling [PDF]

Nephrology Dialysis Transplantation, 2013
This chapter explains that cells communicate with one another using chemical or electrical signals that activate complex signalling pathways. It describes the cells of animals and plants which communicate using extracellular messengers or ligands, noting that local communication occurs by secreting and receiving local-acting extracellular messengers ...
K. Tsuchiya, S. Shiohira, H. Sugiura, M. Suzuki, K. Okano, K. Nitta, N. Kaesler, S. Immendorf, C. Ouyang, P. Carmeliet, J. Floege, T. Kruger, G. Schlieper, A. Georgescu, J. Kalucka, S. Olbrich, J. Baumgartl, T. Hackenbeck, K.-U. Eckardt, A. Weidemann, S. Chmielewski, A. Olejnik, K. Sikorski, U. Heemann, J. Wesoly, H. Bluyssen, M. Baumann, D. Mekahli, J.-P. Decuypere, L. Missiaen, E. Levtchenko, H. De Smedt, A. Stasi, G. Castellano, M. Gigante, A. Intini, P. Pontrelli, C. Divella, C. Curci, G. Grandaliano, L. Gesualdo, D. Vizza, A. Perri, D. Lofaro, P. Toteda, S. Lupinacci, F. Leone, P. Gigliotti, T. Papalia, R. Bonofiglio, A. V. Vatazin, P. V. Astakhov, A. B. Zulkarnaev, E. Parodi, D. Verzola, E. D'Amato, F. Viazzi, A. Gonnella, D. Garneri, R. Pontremoli, G. Garibotto, T.-H. Chen, C.-H. Chen, Y.-C. Chen, Y.-M. Sue, C.-Y. Cheng, L. Guiying, L. Ying, S. Pozzoli, M. Lino, S. Delli Carpini, M. Ferrandi, G. Zerbini, M. Simonini, L. Zagato, I. Molinari, L. Citterio, P. Manunta, X. Feng, X. Pan, W. Wang, N. Chen, Y.-x. Chen, W.-M. Wang, N. Chen, S. Tanaka, S. Yano, T. Sugimoto, H. Noh, M. R. Yu, H. J. Kim, S. A. Woo, Y. J. Cho, S. H. Kwon, J. S. Jeon, D. C. Han, H. Shimizu, M. Yisireyili, F. Nishijima, T. Niwa, E. S. Koh, S. Chung, S. J. Kim, S. J. Kim, H. E. Yoon, C. W. Park, Y. S. Chang, S. J. Shin, E. Y. Seong, H. Rhee, M. J. Shin, B. Y. Yang, Y. S. Jung, D. W. Lee, S. B. Lee, I. S. Kwak, I. Y. Kim, S. M. Sancho-Martinez, L. Prieto-Garcia, F. J. Lopez-Hernandez, J. M. Lopez-Novoa, E. H. Bae, H. S. Choi, S. Y. Joo, I. J. Kim, C. S. Kim, J. S. Choi, S. K. Ma, J. Lee, S. W. Kim, B. Humanes, C. Sonia, J. Jado, M. Mojena, J. Lara, L. Alvarez-Sala, A. Tejedor, A. Lazaro, Y. Wada, M. Iyoda, K. Matsumoto, Y. Shindo-Hirai, Y. Kuno, Y. Yamamoto, T. Suzuki, T. Shibata, T. Akizawa, D. W. Lee, I. S. Kwak, S. B. Lee, E. Y. Seong, S. Faubel, C. L. Edelstein, J. L. Cano Penalver, S. de Frutos Garcia, M. Griera Merino, A. Luengo Rodriguez, A. Garcia Jerez, L. Bohorquez Magro, D. Medrano, L. Calleros Basilio, M. Rodriguez Puyol, L. Prieto-Garcia, S. M. Sancho-Martinez, F. J. Lopez-Hernandez, J. M. Lopez-Novoa, F. Thilo, Y. Liu, M. Tepel, H.-H. Hsu, K.-H. Chen, C.-C. Hung, C.-W. Yang, N. Endlich, J.-L. Lin, H. Pavenstadt, R. R. Rodrigues Diez, S. Mezzano, M. Ruiz-Ortega, R. Rodrigues Diez, C. Lavoz, Y. Nakayama, K. Fukami, S.-i. Yamagishi, N. Obara, M. Yokoro, R. Ando, Y. Kaida, M. Toyonaga, K. Kaifu, M. Takeuchi, S. Ueda, S. Okuda, K. Daenen, M. F. Hoylaerts, B. Bammens, J. Liu, F. Zhong, Q. Dai, L. Xu   +199 more
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Source, co-occurrence, and prognostic value of PTEN mutations or loss in colorectal cancer

npj Genomic Medicine, 2023
Somatic PTEN mutations are common and have driver function in some cancer types. However, in colorectal cancers (CRCs), somatic PTEN-inactivating mutations occur at a low frequency (~8–9%), and whether these mutations are actively selected and promote ...
Ilya G. Serebriiskii, Valerii A. Pavlov, Grigorii V. Andrianov, Samuel Litwin, Stanley Basickes, Justin Y. Newberg, Garrett M. Frampton, Joshua E. Meyer, Erica A. Golemis   +8 more
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Cell receptors and cell signalling [PDF]

Molecular Pathology, 2000
All cells in a multicellular organism are constantly exposed to a variety of extracellular signals that they need to interpret and translate into an appropriate response to their environment. These signals can be soluble factors generated locally (for example, synaptic transmission) or distantly (for example, hormones and growth factors), ligands on ...
I J, Uings, S N, Farrow
openaire   +2 more sources

Molecular and Cellular Mechanisms of Vascular Development in Zebrafish

Life, 2021
The establishment of a functional cardiovascular system is crucial for the development of all vertebrates. Defects in the development of the cardiovascular system lead to cardiovascular diseases, which are among the top 10 causes of death worldwide ...
Jean Eberlein, Lukas Herdt, Julian Malchow, Annegret Rittershaus, Stefan Baumeister, Christian SM Helker   +5 more
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HIV-1 Activates T Cell Signaling Independently of Antigen to Drive Viral Spread [PDF]

, 2016
open access articleHIV-1 spreads between CD4 T cells most efficiently through virus-induced cell-cell contacts. To test whether this process potentiates viral spread by activating signaling pathways, we developed an approach to analyze the ...
Jolly, Clare, Len, Alice C.L., Shivkumar, Maitreyi, Starling, Shimona   +3 more
core   +2 more sources