Results 1 to 10 of about 5,810,399 (215)
Regulation of starvation-induced hyperactivity by insulin and glucagon signaling in adult Drosophila
eLife, 2016 Starvation induces sustained increase in locomotion, which facilitates food localization and acquisition and hence composes an important aspect of food-seeking behavior. We investigated how nutritional states modulated starvation-induced hyperactivity in
Yue Yu +7 more
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Replication-competent adenovirus reporters utilizing endogenous viral expression architecture
Journal of VirologyAdenoviruses are double-stranded DNA viruses widely used as platforms for vaccines, oncolytics, and gene delivery. However, tools for studying adenoviral gene expression in real time during infection remain limited. Here, we describe a set of fluorescent
Claire M. O’Brien +6 more
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Somatic loss of estrogen receptor beta and p53 synergize to induce breast tumorigenesis
Breast Cancer Research, 2017 Background Upregulation of estrogen receptor beta (ERβ) in breast cancer cells is associated with epithelial maintenance, decreased proliferation and invasion, and a reduction in the expression of the receptor has been observed in invasive breast tumors.
Igor Bado +8 more
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TIA1 oxidation inhibits stress granule assembly and sensitizes cells to stress-induced apoptosis
Nature Communications, 2016 Cytoplasmic stress granules (SG) are intracellular aggregates that suppress translation and sequester apoptosis regulatory factors. Here the authors show that reactive oxygen species oxidise the SG-nucleating protein TIA1, preventing SG formation and ...
Kyoko Arimoto-Matsuzaki +2 more
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Cell Death DiscoveryThe phospholipid scramblases Xkr8 and TMEM16F externalize phosphatidylserine (PS) by distinct mechanisms. Xkr8 is activated by caspase-mediated proteolytic cleavage and, in synergy with the inactivation of P4-ATPase flippases, results in the irreversible
Varsha Gadiyar +15 more
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Thermal gradient ring for analysis of temperature-dependent behaviors involving TRP channels in mice
Journal of Physiological SciencesThere are a lot of temperature-sensitive proteins including transient receptor potential (TRP) channels. Some TRP channels are temperature receptors having specific activation temperatures in vitro that are within the physiological temperature range ...
Tomoyo Ujisawa +3 more
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Apoptosis signal-regulating kinase 1 promotes inflammation in senescence and aging
Communications BiologyCellular senescence is a stress-induced, permanent cell cycle arrest involved in tumor suppression and aging. Senescent cells secrete bioactive molecules such as pro-inflammatory cytokines and chemokines.
Takeru Odawara +2 more
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Basic and Clinical Neuroscience, 2020 Introduction: Methomyl (MET) is a carbamate insecticide, used in agriculture and public health to eliminate harmful insects. Besides its advantages in agriculture, it causes neurotoxic effects.
Khene M’hammed Amin +7 more
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Harnessing ferroptosis for precision oncology: challenges and prospects
BMC BiologyThe discovery of diverse molecular mechanisms of regulated cell death has opened new avenues for cancer therapy. Ferroptosis, a unique form of cell death driven by iron-catalyzed peroxidation of membrane phospholipids, holds particular promise for ...
Roberto Fernández-Acosta +4 more
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