Results 31 to 40 of about 5,810,399 (215)
Automated single-molecule imaging in living cells
Nature Communications, 2018 Large scale live cell screens often lack single-molecule resolution. Here the authors present an artificial intelligence-assisted TIRF microscope with automated cell searching and focusing, and use it for high-throughput single-molecule imaging of EGFR ...
Masato Yasui +4 more
doaj +1 more source
Evolving artificial cell signaling networks using molecular classifier systems [PDF]
, 2006 Nature is a source of inspiration for computational techniques which have been successfully applied to a wide variety of complex application domains. In keeping with this we examine Cell Signaling Networks (CSN) which are chemical networks responsible ...
James Decraene +5 more
core +2 more sources
A20 deubiquitinase controls PGC-1α expression in the adipose tissue
Lipids in Health and Disease, 2018 Background Peroxisome proliferator-activated receptor γ coactivator- 1alpha (PGC-1α) plays an important role in whole body metabolism and, particularly in glucose homeostasis.
Bruna Bombassaro +8 more
doaj +1 more source
Cell Death and Disease, 2020 Radiotherapy is commonly used as a cytotoxic treatment of a wide variety of tumors. Interestingly, few case reports underlined its potential to induce immune-mediated abscopal effects, resulting in regression of metastases, distant from the irradiated ...
Sandy Adjemian +13 more
doaj +1 more source
Systematic analysis of the intersection of disease mutations with protein modifications
BMC Medical Genomics, 2019 Background Perturbed posttranslational modification (PTM) landscapes commonly cause pathological phenotypes. The Cancer Genome Atlas (TCGA) project profiles thousands of tumors allowing the identification of spontaneous cancer-driving mutations, while ...
Claire M. Simpson +3 more
doaj +1 more source
Prostate apoptosis response-4 and tumor suppression: it’s not just about apoptosis anymore
Cell Death and Disease, 2021 The tumor suppressor prostate apoptosis response-4 (Par-4) has recently turned ‘twenty-five’. Beyond its indisputable role as an apoptosis inducer, an increasing and sometimes bewildering, new roles for Par-4 are being reported.
Anees Rahman Cheratta +5 more
doaj +1 more source
, 2020 The knowledge about the molecular alterations which are found in head and neck squamous cell carcinomas (HNSCC) has much increased in recent years. However, we are still awaiting the translation of this knowledge to new diagnostic and therapeutic options.
Jarosław Paluszczak
core +1 more source
Direct control of lysosomal catabolic activity by mTORC1 through regulation of V-ATPase assembly
Nature Communications, 2022 mTORC1 blocks lysosomal nutrient generation. Here, the authors show that mTORC1 inactivation triggers V-ATPase assembly, which rapidly initiates lysosomal acidification and degradation of protein contents throughout the lysosomal population.
Edoardo Ratto +6 more
doaj +1 more source
Absence of EPAC1 Signaling to Stabilize CFTR in Intestinal Organoids
, 2022 The plasma membrane (PM) stability of the cystic fibrosis transmembrane conductance regulator (CFTR), the protein which when mutated causes Cystic Fibrosis (CF), relies on multiple interaction partners that connect CFTR to signaling pathways, including ...
Amaral, Margarida D. +9 more
core +1 more source
Nature Communications, 2021 Cells experience various osmotic perturbation, but cellular osmosensing mechanisms remain obscure. Here, the authors report that cells recognize osmotic stress from the inside through macromolecular crowding-driven and poly(ADP-ribose)-conditioned liquid–
Kengo Watanabe +7 more
doaj +1 more source