Results 31 to 40 of about 2,233,123 (318)
The Effects of Cannabidiol on Aqueous Humor Outflow and Trabecular Meshwork Cell Signaling
, 2022 Intraocular pressure (IOP) is regulated primarily through aqueous humor production by ciliary body and drainage through uveoscleral and trabecular meshwork (TM) tissues.
Aebersold, Alyssa S. +3 more
core +1 more source
A20 deubiquitinase controls PGC-1α expression in the adipose tissue
Lipids in Health and Disease, 2018 Background Peroxisome proliferator-activated receptor γ coactivator- 1alpha (PGC-1α) plays an important role in whole body metabolism and, particularly in glucose homeostasis.
Bruna Bombassaro +8 more
doaj +1 more source
Cold Spring Harbor Perspectives in Biology, 2015 In multicellular organisms, cell death is a critical and active process that maintains tissue homeostasis and eliminates potentially harmful cells. There are three major types of morphologically distinct cell death: apoptosis (type I cell death), autophagic cell death (type II), and necrosis (type III).
Douglas R, Green, Fabien, Llambi
openaire +2 more sources
Cell Death and Disease, 2020 Radiotherapy is commonly used as a cytotoxic treatment of a wide variety of tumors. Interestingly, few case reports underlined its potential to induce immune-mediated abscopal effects, resulting in regression of metastases, distant from the irradiated ...
Sandy Adjemian +13 more
doaj +1 more source
Prostate apoptosis response-4 and tumor suppression: it’s not just about apoptosis anymore
Cell Death and Disease, 2021 The tumor suppressor prostate apoptosis response-4 (Par-4) has recently turned ‘twenty-five’. Beyond its indisputable role as an apoptosis inducer, an increasing and sometimes bewildering, new roles for Par-4 are being reported.
Anees Rahman Cheratta +5 more
doaj +1 more source
, 2021 Peripheral immune regulation is critical for the maintenance of self-tolerance. Here we have investigated signaling processes that distinguish T cells with regulatory capability from effector T cells.
Yikui Li +10 more
core +1 more source
Systematic analysis of the intersection of disease mutations with protein modifications
BMC Medical Genomics, 2019 Background Perturbed posttranslational modification (PTM) landscapes commonly cause pathological phenotypes. The Cancer Genome Atlas (TCGA) project profiles thousands of tumors allowing the identification of spontaneous cancer-driving mutations, while ...
Claire M. Simpson +3 more
doaj +1 more source
The Multiple Interactions of RUNX with the Hippo–YAP Pathway
, 2021 The Hippo–YAP signaling pathway serves roles in cell proliferation, stem cell renewal/maintenance, differentiation and apoptosis. Many of its functions are central to early development, adult tissue repair/regeneration and not surprisingly, tumorigenesis
Chuang, Linda Shyue Huey +3 more
core +1 more source
Direct control of lysosomal catabolic activity by mTORC1 through regulation of V-ATPase assembly
Nature Communications, 2022 mTORC1 blocks lysosomal nutrient generation. Here, the authors show that mTORC1 inactivation triggers V-ATPase assembly, which rapidly initiates lysosomal acidification and degradation of protein contents throughout the lysosomal population.
Edoardo Ratto +6 more
doaj +1 more source
Mitochondria and cell signalling
Journal of Cell Science, 2012 Mitochondria have long been considered as crucial organelles, primarily for their roles in biosynthetic reactions such as ATP synthesis. However, it is becoming increasingly apparent that mitochondria are intimately involved in cell signalling pathways. Mitochondria perform various signalling functions, serving as platforms to initiate cell signalling,
Stephen W G, Tait, Douglas R, Green
openaire +3 more sources