The Role of BANK1 in B Cell Signaling and Disease [PDF]
, 2021 The preparation of this review was funded by the Ministerio de Economia y Competitividad (now Ministerio de Ciencia e Innovacion) of the Government of Spain with number SAF2016-78631-P. G.G.H.
Gonzalo Gómez Hernández +5 more
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Intrinsically Disordered Proteins Play Diverse Roles in Cell Signaling [PDF]
, 2022 Signaling pathways allow cells to detect and respond to a wide variety of chemical (e.g. Ca2+ or chemokine proteins) and physical stimuli (e.g., sheer stress, light).
Uversky, Vladimir N. +2 more
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FNBP1 Facilitates Cervical Cancer Cell Survival by the Constitutive Activation of FAK/PI3K/AKT/mTOR Signaling [PDF]
, 2023 Cervical cancer is the most prevalent gynecological tumor among women worldwide. Although the incidence and mortality of cervical cancer have been declining thanks to the wide-scale implementation of cytological screening, it remains a major challenge in
Jun Zhang +5 more
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NOTCH1 Signaling in Head and Neck Squamous Cell Carcinoma [PDF]
, 2020 Biomarker-driven targeted therapies are lacking for head and neck squamous cell carcinoma (HNSCC), which is common and lethal. Efforts to develop such therapies are hindered by a genomic landscape dominated by the loss of tumor suppressor function ...
Faye M. Johnson +7 more
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The Significance of the Dysregulation of Canonical Wnt Signaling in Head and Neck Squamous Cell Carcinomas [PDF]
, 2020 The knowledge about the molecular alterations which are found in head and neck squamous cell carcinomas (HNSCC) has much increased in recent years. However, we are still awaiting the translation of this knowledge to new diagnostic and therapeutic options.
Jarosław Paluszczak
core +1 more source
The Effects of Cannabidiol on Aqueous Humor Outflow and Trabecular Meshwork Cell Signaling [PDF]
, 2022 Intraocular pressure (IOP) is regulated primarily through aqueous humor production by ciliary body and drainage through uveoscleral and trabecular meshwork (TM) tissues.
Aebersold, Alyssa S. +3 more
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Hedgehog Signaling in Cortical Development [PDF]
, 2023 The Hedgehog (Hh) pathway plays a crucial role in embryonic development, acting both as a morphogenic signal that organizes tissue formation and a potent mitogenic signal driving cell proliferation.
Xuecai Ge +5 more
core +1 more source
A LAT-Based Signaling Complex in the Immunological Synapse as Determined with Live Cell Imaging Is Less Stable in T Cells with Regulatory Capability [PDF]
, 2021 Peripheral immune regulation is critical for the maintenance of self-tolerance. Here we have investigated signaling processes that distinguish T cells with regulatory capability from effector T cells.
Yikui Li +10 more
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The Multiple Interactions of RUNX with the Hippo–YAP Pathway [PDF]
, 2021 The Hippo–YAP signaling pathway serves roles in cell proliferation, stem cell renewal/maintenance, differentiation and apoptosis. Many of its functions are central to early development, adult tissue repair/regeneration and not surprisingly, tumorigenesis
Chuang, Linda Shyue Huey +3 more
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Fibroblast Growth Factor Receptors (FGFRs) and Noncanonical Partners in Cancer Signaling [PDF]
, 2021 Increasing evidence indicates that success of targeted therapies in the treatment of cancer is context-dependent and is influenced by a complex crosstalk between signaling pathways and between cell types in the tumor.
Chiara Francavilla +2 more
core +1 more source