Results 11 to 20 of about 5,810,399 (215)

Androgen signaling uses a writer and a reader of ADP-ribosylation to regulate protein complex assembly

Nature Communications, 2021
Androgen receptor (AR) signaling is regulated by multiple post-translational modifications. Here, the authors identify the writer and reader enzymes for AR ADP-ribosylation and show how they modulate AR signaling output in prostate cancer cells.
Chun-Song Yang, Kasey Jividen, Teddy Kamata, Natalia Dworak, Luke Oostdyk, Bartlomiej Remlein, Yasin Pourfarjam, In-Kwon Kim, Kang-Ping Du, Tarek Abbas, Nicholas E. Sherman, David Wotton, Bryce M. Paschal   +12 more
doaj   +1 more source

Pan-cancer predictions of transcription factors mediating aberrant DNA methylation

Epigenetics & Chromatin, 2022
Background Aberrant DNA methylation is a hallmark of cancer cells. However, the mechanisms underlying changes in DNA methylation remain elusive. Transcription factors initially thought to be repressed from binding by DNA methylation, have recently ...
Dylane Detilleux, Yannick G. Spill, Delphine Balaramane, Michaël Weber, Anaïs Flore Bardet   +4 more
doaj   +1 more source

The Effects of Cannabidiol on Aqueous Humor Outflow and Trabecular Meshwork Cell Signaling [PDF]

, 2022
Intraocular pressure (IOP) is regulated primarily through aqueous humor production by ciliary body and drainage through uveoscleral and trabecular meshwork (TM) tissues.
Aebersold, Alyssa S., Song, Zhao-Hui, Zhao-Hui Song, Alyssa S. Aebersold   +3 more
core   +1 more source

Source, co-occurrence, and prognostic value of PTEN mutations or loss in colorectal cancer

npj Genomic Medicine, 2023
Somatic PTEN mutations are common and have driver function in some cancer types. However, in colorectal cancers (CRCs), somatic PTEN-inactivating mutations occur at a low frequency (~8–9%), and whether these mutations are actively selected and promote ...
Ilya G. Serebriiskii, Valerii A. Pavlov, Grigorii V. Andrianov, Samuel Litwin, Stanley Basickes, Justin Y. Newberg, Garrett M. Frampton, Joshua E. Meyer, Erica A. Golemis   +8 more
doaj   +1 more source

Molecular and Cellular Mechanisms of Vascular Development in Zebrafish

Life, 2021
The establishment of a functional cardiovascular system is crucial for the development of all vertebrates. Defects in the development of the cardiovascular system lead to cardiovascular diseases, which are among the top 10 causes of death worldwide ...
Jean Eberlein, Lukas Herdt, Julian Malchow, Annegret Rittershaus, Stefan Baumeister, Christian SM Helker   +5 more
doaj   +1 more source

Dietary fats promote functional and structural changes in the median eminence blood/spinal fluid interface—the protective role for BDNF

Journal of Neuroinflammation, 2018
Background The consumption of large amounts of dietary fats activates an inflammatory response in the hypothalamus, damaging key neurons involved in the regulation of caloric intake and energy expenditure.
Albina F. Ramalho, Bruna Bombassaro, Nathalia R. Dragano, Carina Solon, Joseane Morari, Milena Fioravante, Roberta Barbizan, Licio A. Velloso, Eliana P. Araujo   +8 more
doaj   +1 more source

The ATP-Releasing Maxi-Cl Channel: Its Identity, Molecular Partners, and Physiological/Pathophysiological Implications

Life, 2021
The Maxi-Cl phenotype accounts for the majority (app. 60%) of reports on the large-conductance maxi-anion channels (MACs) and has been detected in almost every type of cell, including placenta, endothelium, lymphocyte, cardiac myocyte, neuron, and glial ...
Ravshan Z. Sabirov, Md. Rafiqul Islam, Toshiaki Okada, Petr G. Merzlyak, Ranokhon S. Kurbannazarova, Nargiza A. Tsiferova, Yasunobu Okada   +6 more
doaj   +1 more source

Inhibition of hypothalamic leukemia inhibitory factor exacerbates diet-induced obesity phenotype

Journal of Neuroinflammation, 2017
Background The consumption of large amounts of dietary fats can trigger an inflammatory response in the hypothalamus and contribute to the dysfunctional control of caloric intake and energy expenditure commonly present in obesity.
Milena Fioravante, Bruna Bombassaro, Albina F. Ramalho, Nathalia R. Dragano, Joseane Morari, Carina Solon, Natalia Tobar, Celso D. Ramos, Licio A. Velloso   +8 more
doaj   +1 more source

Interleukin-6 actions in the hypothalamus protects against obesity and is involved in the regulation of neurogenesis

Journal of Neuroinflammation, 2021
Background Interleukin-6 (IL6) produced in the context of exercise acts in the hypothalamus reducing obesity-associated inflammation and restoring the control of food intake and energy expenditure.
Vanessa C. Bobbo, Daiane F. Engel, Carlos Poblete Jara, Natalia F. Mendes, Roberta Haddad-Tovolli, Thais P. Prado, Davi Sidarta-Oliveira, Joseane Morari, Licio A. Velloso, Eliana P. Araujo   +9 more
doaj   +1 more source

PI3K-C2 alpha Knockdown Results in Rerouting of Insulin Signaling and Pancreatic Beta Cell Proliferation [PDF]

, 2018
Insulin resistance is a syndrome that affects multiple insulin target tissues, each having different biological functions regulated by insulin. A remaining question is to mechanistically explain how an insulin target cell/tissue can be insulin resistant ...
Berggren, PO, Leibiger, IB, Paschen, M, Yunn, NO, Lim, JH, Leibiger, B, Ryu, SH, Moede, T, Pereira, T   +8 more
core   +1 more source