Results 241 to 250 of about 1,828,344 (305)

RETRACTION: The PI3K/mTOR Dual Inhibitor NVP‐BEZ235 Stimulates Mutant p53 Degradation to Exert Anti‐Tumor Effects on Triple‐Negative Breast Cancer Cells

FEBS Open Bio, EarlyView.
RETRACTION: J. Cai, J. Xia, J. Zou, Q. Wang, Q. Ma, R. Sun, H. Liao, L. Xu, D. Wang, and X. Guo, “The PI3K/mTOR Dual Inhibitor NVP‐BEZ235 Stimulates Mutant p53 Degradation to Exert Anti‐Tumor Effects on Triple‐Negative Breast Cancer Cells,” FEBS Open Bio 10, no. 4 (2020): 535–545, https://doi.org/10.1002/2211‐5463.12806.
wiley   +1 more source

Lessons Learned From a Delayed‐Start Trial of Modafinil for Freezing of Gait in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Freezing of gait (FOG) in people with Parkinson's disease (PwPD) is debilitating and has limited treatments. Modafinil modulates beta/gamma band activity in the pedunculopontine nucleus (PPN), like PPN deep brain stimulation. We therefore tested the hypothesis that Modafinil would improve FOG in PwPD.
Tuhin Virmani, Lakshmi Pillai, Reid D. Landes, Aliyah Glover, Shannon Doerhoff, Jennifer Kleiner, Mitesh Lotia, Rohit Dhall, Edgar Garcia‐Rill   +8 more
wiley   +1 more source

In‐Depth Profiling Highlights the Effect of Efgartigimod on Peripheral Innate and Adaptive Immune Cells in Myasthenia Gravis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is an autoimmune disorder characterized by antibody‐mediated complement activation. Efgartigimod, a neonatal Fc receptor (FcRn) antagonist, is approved for treating generalized MG (gMG). However, its modulatory effects on upstream innate and adaptive immune cells remain largely unexplored.
Lei Jin, Liu Dong, Ying Wang, Dingxian He, Chong Yan, Jianying Xi, Haoqin Jiang, Yu Shi, Ming Guan, Chongbo Zhao, Jie Song, Sushan Luo   +11 more
wiley   +1 more source

The Case of a 28‐Year‐Old Man With Gradually Progressive Proximal Leg Weakness

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT This is a case of a 28‐year‐old man who presented with a 6‐month history of gradually progressive proximal leg weakness and pain that worsened on exercise and was relieved by rest. He had no symptoms in his upper limbs. Apart from intermittent mild ptosis and diplopia, he had no other cranial nerve symptoms.
Melody T. Asukile, Musambo Kapapa, Emelda Mwingila, Michelle Kvalsund   +3 more
wiley   +1 more source

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B-cell stimulation

Current Opinion in Immunology, 1995
Recent studies have identified CD40 ligand (CD40L) as the critical membrane-expressed molecule responsible for T cell dependent B-cell activation. CD40L co-operates with various cytokines to induce B-cell activation, proliferation, and immunoglobulin isotype switching.
R J, Armitage, M R, Alderson
openaire   +2 more sources

Bone-Cell-Stimulating Substance

Clinical Orthopaedics and Related Research, 1988
An acid-pepsin extract of ground cancellous calf bone contains a bone-cell-stimulating substance (BCSS) that is active in the intact rat and in bone cultures. A single injection of a suspension of BCSS adjacent to the radius-ulna complex of a rat significantly increased appositional bone formation in a dose-dependent manner.
I, Clark, J P, Zawadsky, W, Lin, R A, Berg   +3 more
openaire   +2 more sources

Stimulation of Lymphocytes by Spermatozoa‐Stimulated Cells*

American Journal of Reproductive Immunology, 1982
ABSTRACT: The mechanism of spermatozoalymphocyte interaction was studied using spermatozoa and lymphocytes obtained from 11 healthy individuals and from 2 patients with spermatocoele. The lymphocytes activated by spermatozoa in 3‐day cultures were used as inducers of fresh, unstimulated autologous or allogeneic lymphocytes.
M, Kurpisz, G A, Szymczynski
openaire   +2 more sources

Microglia stimulate naive T‐cell differentiation without stimulating T‐cell proliferation

Journal of Neuroscience Research, 1999
A major question relevant to the initiation and progression of inflammation and autoimmune processes within the central nervous system (CNS) is whether resident microglia or only infiltrating macrophage can productively interact with T-cells that enter the CNS either actively through extravasation or passively through defects in the blood brain barrier
M J, Carson, J G, Sutcliffe, I L, Campbell   +2 more
openaire   +2 more sources

Magnetomechanical stimulation of mesenchymal cells

Journal of Inorganic Biochemistry, 1995
The method presented in this article for the mechanical stimulation of cells via specific receptors was adapted from the method of Wang and Ingber.1,2 Unlike most current methods which apply strain to the cell as a whole, our method is able to determine the specific receptors involved in stress transduction.
Susanne Bierbaum, Holger Notbohm
openaire   +1 more source

tDCS possibly stimulates glial cells

Clinical Neurophysiology, 2012
Explore the possibility that transcranial direct current stimulation (tDCS) of the brain affects glial cells.Cable theory is used to estimate roughly transmembrane potential in neurons and glial cells. tDCS is additionally compared to neuronal stimulation techniques for which the mechanisms are well known.Theoretical calculations indicated that tDCS ...
Jarmo, Ruohonen, Jari, Karhu
openaire   +2 more sources