Results 171 to 180 of about 3,396,679 (311)

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

scSurv: a deep generative model for single-cell survival analysis. [PDF]

Bioinformatics
Mizukoshi C, Kojima Y, Hayashi S, Abe K, Kasugai D, Shimamura T.   +5 more
europepmc   +1 more source

Small Peptide Analogue of SDF-1α Supports Survival of Cord Blood CD34+ Cells in Synergy with Other Cytokines and Enhances Their Ex Vivo Expansion and Engraftment into Nonobese Diabetic/Severe Combined Immunodeficient Mice [PDF]

, 2005
Karen Li, Carmen Ka Yee Chuen, Shuk Man Lee, Ping‐Yee Law, Tai Fai Fok, Pak Cheung Ng, Chi Kong Li, Donald Wong, Ahmed Merzouk, Hassan Salari, Goldie Jia-Shi Gu, Patrick Man Pan Yuen   +11 more
openalex   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Histone acetylation homeodynamics navigates cell survival and apoptosis. [PDF]

Nat Commun
Li K, Tian L, Cao W, Zhang J, Zhang W, Lin T, Huang S, Qiu Y, Ruan Z, Deng J, Long S, Palli SR, Li S.   +12 more
europepmc   +1 more source

Cell death and survival pathways in Alzheimer's disease: an integrative hypothesis testing approach utilizing -omic data sets

, 2020
Danielle Brokaw, Ignazio S. Piras, Diego Mastroeni, Daniel J. Weisenberger, Jennifer Nolz, Elaine Delvaux, Geidy E. Serrano, Thomas G. Beach, Matthew J. Huentelman, Paul D. Coleman   +9 more
openalex   +2 more sources

Prolongation of Allograft Survival by Administration of Anti-CD45RB Monoclonal Antibody Is Due to Alteration of CD45RBhi: CD45RBlo T-Cell Proportions [PDF]

, 2006
Patrick Luke, Jianchuan Deng, D. Lian, Peta J. O’Connell, B. García, Anthony M. Jevnikar, Robert Zhong   +6 more
openalex   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Regulation of stress tolerance by CREB1 sustains multiple myeloma cell survival. [PDF]

Cell Death Dis
Kudalkar R, Altom J, Galloway J, Manning V, Taranto S, Cottini F.   +5 more
europepmc   +1 more source

Determination of Hemolytic Anemia Through the Study of 51Cr Red Cell Survival and Splenic Sequestration [PDF]

, 2008
AIMEE WILLETT, V. Grantham
openalex   +1 more source