Results 201 to 210 of about 1,962,460 (268)

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

The dark side of the light (UVA): melanoma microenvironment and cell survival strategies. [PDF]

Cell Death Discov
Basu A, Thorsten P, Schumacher B, Kletsas D, Scharffetter-Kochanek K.   +4 more
europepmc   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Dissecting the Biological Functions of Various Isoforms of Ferredoxin Reductase for Cell Survival and DNA Damage Response. [PDF]

Cells
Nakajima KI, Mohibi S, Hong K, Chen X, Zhang J.   +4 more
europepmc   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

CXCR6 promotes dermal CD8+ T cell survival and transition to long-term tissue residence. [PDF]

J Immunol
Heim TA, Ibrahim O, Lin Z, Schultz AC, Steele MM, Mudianto T, Lund AW.   +6 more
europepmc   +1 more source

Induction of TFEB promotes Kupffer cell survival and reduces lipid accumulation in MASLD. [PDF]

Hepatol Commun
Chan MM, Daemen S, Beatty W, Byrnes K, Cho K, Ferguson D, Feldstein N, Park C, Guo Z, Park AC, Fu CF, Florczak KL, He L, Yang BQ, Javaheri A, Patti GJ, Finck BN, Razani B, Schilling JD.   +18 more
europepmc   +1 more source

Critical Role of RPS4X in Modulating SCF Complex Formation and Cell Survival. [PDF]

Biomolecules
Ryu S, Kim MJ, Bando S, Tanaka Y, Mukai R, Ishihara Y, Tominaga T, Ohshima T.   +7 more
europepmc   +1 more source

Glutamine synthetase deficiency enhances CD8 T cell survival and stress resilience in the tumor microenvironment. [PDF]

J Immunol
Fisher-Gupta EL, Hathaway ES, Perera JM, Jennings EQ, Chi C, Sewell AE, Stone SH, Muka JE, Sinard RC, DeCorte JA, Chen H, Wilson JT, Meiler J, Rathmell JC.   +13 more
europepmc   +1 more source

Genome-scale spatial mapping of the Hodgkin lymphoma microenvironment identifies tumor cell survival factors. [PDF]

Nat Commun
Shanmugam V, Tokcan N, Chafamo D, Sullivan S, Borji M, Martin H, Newton G, Nadaf N, Hanbury S, Barrera I, Cable D, Weir J, Ashenberg O, Pinkus G, Rodig S, Uhler C, Macosko E, Shipp M, Louissaint A, Chen F, Golub TR.   +20 more
europepmc   +1 more source