Results 211 to 220 of about 2,117,768 (268)

In vivo CAR-cell therapy: current challenges and emerging therapeutic advances. [PDF]

Mol Biomed
Yang YM, Bao B, Cao YH, Yao J, Ding YF, Hu YY, Fan F, Zhao JL.   +7 more
europepmc   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Biomarker-empowered precision navigation of CAR-T cell therapy. [PDF]

Mol Cancer
Wang Y, Cheng W, Kang K, Niu T, Zhao A, Wu Y.   +5 more
europepmc   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Neurological implications of chimeric antigen receptor-T cell therapy. [PDF]

BMJ Neurol Open
Raffoul DG, Roos I, Mulazzani M, Anderson MA, Monif M, Garber J, van der Walt A, Massey J, Kuznetsova V, Nesbitt C, Dowling M, Ruderman I, Lasocki A, Tam CS, Harrison SJ, Kalincik T.   +15 more
europepmc   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Epigenetic editing to advance CAR T cell therapy. [PDF]

Clin Epigenetics
Horvathova L, Rots MG, Wiersma VR.
europepmc   +1 more source

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

Endothelial Cell Therapy for the Acute and Chronic Liver Disease. [PDF]

Semin Liver Dis
Mahmut D, Gouon-Evans V.
europepmc   +1 more source

Editorial: Advancements and challenges in CAR-T cell therapy for cancer treatment. [PDF]

Front Pharmacol
Sougiannis AT, Meneses Acosta A, Ferreira LMR.   +2 more
europepmc   +1 more source