Results 41 to 50 of about 2,050,369 (162)

Optimizing the Banking and Releasing Strategies of Clinical-Grade HLA-Homozygous Human iPSCs for Regenerative Medicine

Stem Cells International
Since their initial generation, induced pluripotent stem cells (iPSCs) have attracted considerable attention and undergone rapid development. iPSC-derived cell therapies show great promise in the field of regenerative medicine.
Qianping Zhang, Lijuan Cui, Ying Jia, Xiaohui Shi, Jinmei Zhang, Li Zhang, Zhihui Liu, Yun Zhang, Huizhuan Fu, Qi Qi, Quan Chen, Wei Du, Yu Zhang   +12 more
doaj   +1 more source

Low-liver-accumulation lipid nanoparticles enhance the efficacy and safety of HPV therapeutic tumor vaccines

Journal of Translational Medicine
Background Lipid nanoparticles (LNPs) hold significant potential in vaccine and cancer therapy, but conventional LNPs often cause hepatotoxicity and reduced efficacy due to liver accumulation.
Xiaodie Wang, Zhidan Tian, Meng Wang, Xiaoru Cai, Shuyan Yang, Jianyao Zeng, Yuan Fang, Xuesen Bai, Pei Wang, Yan Sun, Chuanxin Guo, Tao Liu, Qijun Qian   +12 more
doaj   +1 more source

Automated image analysis detects aging in clinical-grade mesenchymal stromal cell cultures

Stem Cell Research & Therapy, 2018
Background Senescent cells are undesirable in cell therapy products due to reduced therapeutic activity and risk of aberrant cellular effects, and methods for assessing senescence are needed. Early-passage mesenchymal stromal cells (MSCs) are known to be
S. Oja, P. Komulainen, A. Penttilä, J. Nystedt, M. Korhonen   +4 more
doaj   +1 more source

Contributions of HOX genes to cancer hallmarks: Enrichment pathway analysis and review

Tumor Biology, 2020
Homeobox genes function as master regulatory transcription factors during development, and their expression is often altered in cancer. The HOX gene family was initially studied intensively to understand how the expression of each gene was involved in ...
Danielle Barbosa Brotto, Ádamo Davi Diógenes Siena, Isabela Ichihara de Barros, Simone da Costa e Silva Carvalho, Bruna Rodrigues Muys, Lucas Goedert, Cibele Cardoso, Jessica Rodrigues Plaça, Anelisa Ramão, Jeremy Andrew Squire, Luiza Ferreira Araujo, Wilson Araújo da Silva   +11 more
doaj   +1 more source

Therapeutic efficacy of thrombin-preconditioned mesenchymal stromal cell-derived extracellular vesicles on Escherichia coli-induced acute lung injury in mice

Respiratory Research
Background Acute lung injury (ALI) following pneumonia involves uncontrolled inflammation and tissue injury, leading to high mortality. We previously confirmed the significantly increased cargo content and extracellular vesicle (EV) production in ...
Yuna Bang, Sein Hwang, Young Eun Kim, Dong Kyung Sung, Misun Yang, So Yoon Ahn, Se In Sung, Kyeung Min Joo, Yun Sil Chang   +8 more
doaj   +1 more source

Why Extracellular Vesicles Are Attractive Vehicles for RNA-Based Therapies?

SynBio
Extracellular Vesicles (EVs) are a focus of intense research worldwide, with many groups exploring their potential for both diagnostic and therapeutic applications. Researchers have characterized EVs into various subtypes, modified common surface markers,
Farah Aqel, Kristin Schneider, Denise Hartung, Kathrin Schwarz, Olga Shatnyeva   +4 more
doaj   +1 more source

Establishing the cost of implementing a performance-based, managed entry agreement for a hypothetical CAR T-cell therapy

Journal of Market Access & Health Policy, 2018
Background: Market access stakeholders consider the adoption of Managed Entry Agreements (MEAs), however a clearly described methodology to quantify their implementation burden is not available in the public domain.
Panos Kefalas, Omar Ali, Jesper Jørgensen, Nick Merryfield, Tim Richardson, Adam Meads, Laura Mungapen, Matthew Durdy   +7 more
doaj   +1 more source

Application of Raman Spectroscopy and Univariate Modelling As a Process Analytical Technology for Cell Therapy Bioprocessing

Frontiers in Medicine, 2018
Cell therapies offer unquestionable promises for the treatment, and in some cases even the cure, of complex diseases. As we start to see more of these therapies gaining market authorization, attention is turning to the bioprocesses used for their ...
Marc-Olivier Baradez, Daniela Biziato, Enas Hassan, Damian Marshall   +3 more
doaj   +1 more source

Cell therapy [PDF]

Bone Marrow Transplantation, 2001
  +6 more sources

Aptamer guided nanomedicines enable precision immune engineering

Discover Applied Sciences
Precision targeting of immune responses is crucial for the ongoing development of therapies for cancer, autoimmune, and infectious diseases. Aptamers, which are short, single-stranded oligonucleotides, are emerging as powerful immunomodulators in ...
Nowar Alsarayreh, Yousef Ijjeh, Hadeel AbuSaifan, Baida’a AlQuaissi, Nirmeen Elzogheir, Dana Alqudah, Sara Al-Mahamid, Somaya Ahmad, Hamdi Nsairat, Alaaldin M. Alkilany, Alqassem Abuarqoub, Mohammad IA Ahmad, Walhan Alshaer   +12 more
doaj   +1 more source