Results 121 to 130 of about 816,794 (268)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Alternatively activated macrophages cause DNA damage through an arginase 1-mediated bystander effect and promote epithelial cell transformation. [PDF]

Oncogenesis
Undi RB, Sutton MM, Becker E, Gordon M, Vesely SK, Ricketts S, Velayutham R, Tierney WM, Houchen CW, Ali N, Huycke MM.   +10 more
europepmc   +1 more source

Genetic Transformation of Perennial Ryegrass for Chemical Induced Elimination

, 2002
Perennial ryegrass (Lolium perenne L.) is an important forage and turfgrass species, widely distributed throughout the world, including North and South America, Europe, New Zealand, and Australia.
Chen, Xi
core  

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Small Cell Transformation of EGFR-Mutant NSCLC Treated with Tyrosine Kinase Inhibition. [PDF]

Curr Oncol
Rock A, Mambetsariev I, Pareek S, Fricke J, Li X, Arias-Romero J, Kareem W, Arvanitis L, Bruno DS, Gray S, Salgia R.   +10 more
europepmc   +1 more source

Microbiome and plant cell transformation trigger insect gall induction in cassava. [PDF]

Front Plant Sci, 2023
Gätjens-Boniche O, Jiménez-Madrigal JP, Whetten RW, Valenzuela-Diaz S, Alemán-Gutiérrez A, Hanson PE, Pinto-Tomás AA.   +6 more
europepmc   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Supranutritional Selenomethionine but not Selenite Reduces Malignant Cell Transformation. [PDF]

Biol Trace Elem Res
Meyer CE, Schwarz M, Meyer FB, Thierbach R, Kipp AP.   +4 more
europepmc   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Large-cell transformation of mycosis fungoides: Patterns of care and patient outcomes. [PDF]

Br J Haematol
Johnstone P, Higgins M, Prince HM, Lade S, McCormack C, van der Weyden C, Bhabha F, Buelens O, Blombery P, Campbell BA.   +9 more
europepmc   +1 more source